{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T16:08:53Z","timestamp":1787242133979,"version":"build-2736575974"},"reference-count":43,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2021,7,12]],"date-time":"2021-07-12T00:00:00Z","timestamp":1626048000000},"content-version":"vor","delay-in-days":192,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004320","name":"Shiraz University of Medical Sciences","doi-asserted-by":"publisher","award":["1396-01-03-14576"],"award-info":[{"award-number":["1396-01-03-14576"]}],"id":[{"id":"10.13039\/501100004320","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Mediators of Inflammation"],"published-print":{"date-parts":[[2021,1]]},"abstract":"<jats:p>\n                    Lichen planus is considered a chronic inflammatory disease which affects different sites, such as the skin, mucous membranes, hair, and nails. Based on the evidence, a complex cytokine network plays a crucial role in lichen planus pathogenesis. The study was aimed at assessing the serum IL\u201023 levels in the patients with cutaneous and oral lichen planus compared to healthy controls.\n                    <jats:italic>Method<\/jats:italic>\n                    . The study included 30 cutaneous lichen planus patients, 20 oral lichen planus patients, and 33 control subjects. Five milliliters of peripheral blood was obtained from each patient, and the serum was separated. IL\u201023 levels were determined using the ELISA kit, and the data were analyzed using the Mann\u2013Whitney test.\n                    <jats:italic>Results<\/jats:italic>\n                    . IL\u201023 levels in the patient serum with oral lichen planus (\n                    <jats:italic>P<\/jats:italic>\n                    value \u2264 0.001) were significantly higher than in controls. Furthermore, there were significant differences in IL\u201023 serum levels in the patients with cutaneous lichen planus compared to the healthy controls (\n                    <jats:italic>P<\/jats:italic>\n                    value \u2264 0.001). Moreover, IL\u201023 serum levels were statistically different between patients with cutaneous lichen planus and patients with oral lichen planus (\n                    <jats:italic>P<\/jats:italic>\n                    value \u2264 0.001). Based on the mean concentration of interleukin\u201023, IL\u201023 levels were higher in the patients with oral lichen planus than in the patients with cutaneous lichen planus.\n                    <jats:italic>Conclusions<\/jats:italic>\n                    . Elevated serum IL\u201023 levels in the patients with oral lichen planus may indicate that IL\u201023 plays a crucial role in the pathogenesis of oral lichen planus. However, more research is needed with a larger sample size.\n                  <\/jats:p>","DOI":"10.1155\/2021\/5578568","type":"journal-article","created":{"date-parts":[[2021,7,12]],"date-time":"2021-07-12T19:20:07Z","timestamp":1626117607000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Elevated Serum Interleukin\u201023 Levels in Patients with Oral and Cutaneous Lichen Planus"],"prefix":"10.1155","volume":"2021","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0479-7291","authenticated-orcid":false,"given":"Maryam","family":"Mardani","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2640-720X","authenticated-orcid":false,"given":"Hossein","family":"Mofidi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2117-9375","authenticated-orcid":false,"given":"Ladan","family":"Dastgheib","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6323-7628","authenticated-orcid":false,"given":"Sara","family":"Ranjbar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2670-7683","authenticated-orcid":false,"given":"Nasrin","family":"Hamidizadeh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,7,12]]},"reference":[{"key":"e_1_2_11_1_2","doi-asserted-by":"publisher","DOI":"10.1155\/2014\/742826"},{"key":"e_1_2_11_2_2","doi-asserted-by":"publisher","DOI":"10.1054\/bjom.2000.0335"},{"key":"e_1_2_11_3_2","doi-asserted-by":"publisher","DOI":"10.4103\/0019-5154.156315"},{"key":"e_1_2_11_4_2","doi-asserted-by":"publisher","DOI":"10.1590\/S0365-05962011000400002"},{"key":"e_1_2_11_5_2","doi-asserted-by":"publisher","DOI":"10.4103\/0973-029X.84474"},{"key":"e_1_2_11_6_2","doi-asserted-by":"publisher","DOI":"10.1177\/154411130201300405"},{"key":"e_1_2_11_7_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0714.2010.00946.x"},{"key":"e_1_2_11_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.biocel.2008.04.027"},{"key":"e_1_2_11_9_2","doi-asserted-by":"publisher","DOI":"10.1038\/ni1497"},{"key":"e_1_2_11_10_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.168.11.5699"},{"key":"e_1_2_11_11_2","doi-asserted-by":"publisher","DOI":"10.1002\/eji.201242598"},{"key":"e_1_2_11_12_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2567.2011.03522.x"},{"key":"e_1_2_11_13_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrrheum.2015.53"},{"key":"e_1_2_11_14_2","doi-asserted-by":"publisher","DOI":"10.1080\/08923973.2019.1610429"},{"key":"e_1_2_11_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.oooo.2016.03.018"},{"key":"e_1_2_11_16_2","first-page":"703","article-title":"Comparison of oral lichen planus and systemic lupus erythematosus in interleukins level","volume":"18","author":"Agha-Hosseini F.","year":"2015","journal-title":"Archives of Iranian Medicine (AIM)"},{"key":"e_1_2_11_17_2","first-page":"176","article-title":"Salivary TNF-[alpha] and sCD44 as markers for disease activity and malignant transformation in oral lichen planus","volume":"9","author":"Zahran F.","year":"2015","journal-title":"Advances in Environmental Biology"},{"key":"e_1_2_11_18_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11596-012-0078-7"},{"key":"e_1_2_11_19_2","doi-asserted-by":"publisher","DOI":"10.1155\/2020\/6521274"},{"key":"e_1_2_11_20_2","doi-asserted-by":"publisher","DOI":"10.1177\/0961203312451200"},{"key":"e_1_2_11_21_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00005-015-0344-z"},{"key":"e_1_2_11_22_2","doi-asserted-by":"publisher","DOI":"10.1080\/21645515.2017.1356498"},{"key":"e_1_2_11_23_2","doi-asserted-by":"publisher","DOI":"10.1097\/BOR.0000000000000147"},{"key":"e_1_2_11_24_2","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.12124"},{"key":"e_1_2_11_25_2","doi-asserted-by":"publisher","DOI":"10.5114\/aoms.2012.32421"},{"key":"e_1_2_11_26_2","doi-asserted-by":"publisher","DOI":"10.1038\/srep18001"},{"key":"e_1_2_11_27_2","first-page":"261","article-title":"Elevated levels of interleukin-23 in sera of patients with pemphigus vulgaris","volume":"9","author":"Pouralibaba F.","year":"2012","journal-title":"Iranian Journal of Immunology"},{"key":"e_1_2_11_28_2","doi-asserted-by":"publisher","DOI":"10.1155\/2014\/463928"},{"key":"e_1_2_11_29_2","doi-asserted-by":"publisher","DOI":"10.1155\/2018\/8206983"},{"key":"e_1_2_11_30_2","doi-asserted-by":"publisher","DOI":"10.1111\/ijd.12392"},{"key":"e_1_2_11_31_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10753-013-9594-2"},{"key":"e_1_2_11_32_2","doi-asserted-by":"publisher","DOI":"10.21608\/zumj.2015.4456"},{"key":"e_1_2_11_33_2","doi-asserted-by":"publisher","DOI":"10.1155\/2013\/801974"},{"key":"e_1_2_11_34_2","doi-asserted-by":"publisher","DOI":"10.30476\/DENTJODS.2020.84667.1096"},{"key":"e_1_2_11_35_2","doi-asserted-by":"publisher","DOI":"10.1155\/2014\/701094"},{"key":"e_1_2_11_36_2","doi-asserted-by":"publisher","DOI":"10.1038\/nri3707"},{"key":"e_1_2_11_37_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1001538"},{"key":"e_1_2_11_38_2","doi-asserted-by":"publisher","DOI":"10.1001\/archdermatol.2007.63"},{"key":"e_1_2_11_39_2","doi-asserted-by":"publisher","DOI":"10.1185\/030079906X120931"},{"key":"e_1_2_11_40_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(18)32167-6"},{"key":"e_1_2_11_41_2","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.14868"},{"key":"e_1_2_11_42_2","doi-asserted-by":"publisher","DOI":"10.1177\/2040622318759282"},{"key":"e_1_2_11_43_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-med-042915-103905"}],"container-title":["Mediators of Inflammation"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/mi\/2021\/5578568.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/mi\/2021\/5578568.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1155\/2021\/5578568","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,28]],"date-time":"2025-08-28T09:25:04Z","timestamp":1756373104000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1155\/2021\/5578568"}},"subtitle":[],"editor":[{"given":"Mirella","family":"Giovarelli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2021,1]]},"references-count":43,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2021,1]]}},"alternative-id":["10.1155\/2021\/5578568"],"URL":"https:\/\/doi.org\/10.1155\/2021\/5578568","archive":["Portico"],"relation":{},"ISSN":["0962-9351","1466-1861"],"issn-type":[{"value":"0962-9351","type":"print"},{"value":"1466-1861","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,1]]},"assertion":[{"value":"2021-03-01","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-06-03","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-07-12","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"5578568"}}