{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T01:49:26Z","timestamp":1787017766360,"version":"build-2736575974"},"reference-count":8,"publisher":"Wiley","license":[{"start":{"date-parts":[[2021,7,15]],"date-time":"2021-07-15T00:00:00Z","timestamp":1626307200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Case Reports in Obstetrics and Gynecology"],"published-print":{"date-parts":[[2021,7,15]]},"abstract":"<jats:p>Endometrial stromal sarcoma (ESS) is a rare and challenging type of endometrial tumor, constituting only about 0.2% of all uterine malignancies and occurring in women 42\u201358 years of age. ESS is usually misdiagnosed as leiomyoma. They both have nonspecific symptoms, which makes the diagnosis of ESS difficult to achieve. As the ESS is infrequently encountered, optimal management is quite debatable. Here, we report a rare case of a 22-year-old Syrian female who presented with abnormal uterine bleeding; the preoperative diagnosis suggested leiomyoma while histopathological and immunohistochemical studies confirmed the diagnosis of LG-ESS stage IIA. Therefore, the treatment plan was shifted from a conservative myomectomy to a total hysterectomy with both adnexa. The aim of this case report is to draw attention to this uncommon tumor at young age of patients as well as to have awareness of the necessity to suspect this diagnosis especially with the presentation of rapid enlargement of uterine leiomyoma.<\/jats:p>","DOI":"10.1155\/2021\/5578686","type":"journal-article","created":{"date-parts":[[2021,7,16]],"date-time":"2021-07-16T21:35:07Z","timestamp":1626471307000},"page":"1-4","source":"Crossref","is-referenced-by-count":3,"title":["Low-Grade Endometrial Stromal Sarcoma in a 22-Year-Old Maiden Female: A Rare Case Report from Syria"],"prefix":"10.1155","volume":"2021","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2345-7009","authenticated-orcid":true,"given":"Lana","family":"Nseir","sequence":"first","affiliation":[{"name":"Department of Pathology, Cancer Research Centre, Tishreen University Hospital, Lattakia, Syria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4049-8598","authenticated-orcid":true,"given":"Georget","family":"Mansour","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Tishreen University, Lattakia, Syria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5202-1896","authenticated-orcid":true,"given":"Junior","family":"Makhoul","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Tishreen University, Lattakia, Syria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6970-3658","authenticated-orcid":true,"given":"Luna","family":"Skaf","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Tishreen University, Lattakia, Syria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2632-7821","authenticated-orcid":true,"given":"Mohammad Ziad","family":"Dahhan","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecology, Al-Tabiat Surgical Hospital, Lattakia, Syria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6519-7954","authenticated-orcid":true,"given":"Zuheir","family":"AlShehabi","sequence":"additional","affiliation":[{"name":"Department of Pathology, Cancer Research Centre, Tishreen University, Lattakia, Syria"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.1055\/a-0882-4116"},{"issue":"3","key":"2","first-page":"933","article-title":"Endometrial stromal sarcoma in a 27-year-old woman. Case report and literature review","volume":"59","author":"F. D. C\u0103lin","year":"2018","journal-title":"Romanian Journal of Morphology and Embryology"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.1007\/s13224-012-0137-9"},{"issue":"12","key":"4","first-page":"8","article-title":"Endometrial stromal sarcoma in a 20-year-old woman","volume":"12","author":"R. Sohail","year":"2019","journal-title":"BML Case Reports"},{"key":"5","doi-asserted-by":"publisher","DOI":"10.4103\/0971-5851.96960"},{"key":"6","doi-asserted-by":"publisher","DOI":"10.1097\/md.0000000000006584"},{"issue":"1","key":"7","first-page":"81","article-title":"Low grade endometrial stromal sarcoma : a case report","volume":"40","author":"R. 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