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In this review, we focused on relatively easy-to-obtain, peripheral markers of oxidative stress and inflammation, in order to compare the levels of these markers in DS patients and chromosomally healthy persons. Studies taking into account age- and sex-matched control groups were of particular interest in this context. We analyzed the factors that influence the levels of said markers in both groups (i.e., the usefulness of the markers), including the age of DS patients, occurrence of regular trisomy 21 or mosaicism, physical activity of patients, and the onset of Alzheimer\u2019s disease in DS. This paper was conceived as a handbook\u2014to help for selecting suitable, easy-to-obtain markers for monitoring of the health status of DS patients (e.g., in nutritional studies and during dietary supplementation).<\/jats:p>","DOI":"10.1155\/2021\/5581139","type":"journal-article","created":{"date-parts":[[2021,6,29]],"date-time":"2021-06-29T19:20:09Z","timestamp":1624994409000},"page":"1-9","source":"Crossref","is-referenced-by-count":4,"title":["Peripheral Oxidation Markers in Down Syndrome Patients: The Better and the Worse"],"prefix":"10.1155","volume":"2021","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2285-0669","authenticated-orcid":true,"given":"Dominik","family":"Szwajgier","sequence":"first","affiliation":[{"name":"Department of Biotechnology, Microbiology and Human Nutrition, University of Life Sciences in Lublin, Skromna 8, 20-704 Lublin, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2213-9631","authenticated-orcid":true,"given":"Ewa","family":"Baranowska-W\u00f3jcik","sequence":"additional","affiliation":[{"name":"Department of Biotechnology, Microbiology and Human Nutrition, University of Life Sciences in Lublin, Skromna 8, 20-704 Lublin, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joanna","family":"Grzelczyk","sequence":"additional","affiliation":[{"name":"Institute of Food Technology and Analysis, Faculty of Biotechnology and Food Sciences, \u0141\u00f3d\u017a University of Technology, 90-924 \u0141\u00f3d\u017a, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wioletta","family":"\u017bukiewicz-Sobczak","sequence":"additional","affiliation":[{"name":"Department of Food and Nutrition, Calisia University, Nowy \u015awiat 4, 62-800 Kalisz, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(03)12987-X"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.1038\/378776a0"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2017.07.009"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2017.08.014"},{"key":"5","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1007\/978-1-4614-0653-2_22","article-title":"Oxidative stress and mitochondrial dysfunction in Down syndrome","volume-title":"Neurodegenerative Diseases. 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