{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T21:30:57Z","timestamp":1777671057088,"version":"3.51.4"},"reference-count":41,"publisher":"Wiley","license":[{"start":{"date-parts":[[2021,4,15]],"date-time":"2021-04-15T00:00:00Z","timestamp":1618444800000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100015690","name":"Universitas Padjadjaran","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100015690","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Academic Leadership Grant"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Anemia"],"published-print":{"date-parts":[[2021,4,15]]},"abstract":"<jats:p>Thalassemia is a genetic disease caused by disruption of globin chain synthesis leading to severe anemia and thus regular blood transfusion is necessary. However, there have been known transfusions-related consequences, including iron overload and multi-organ damage. The aims of this study were to evaluate liver and cardiac function in youth and adult transfusion-dependent Indonesian thalassemic patients and to assess its correlation with serum ferritin levels, as well as T2<jats:inline-formula>\n                     <a:math xmlns:a=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M1\">\n                        <a:msup>\n                           <a:mrow\/>\n                           <a:mrow>\n                              <a:mi>\u2217<\/a:mi>\n                           <\/a:mrow>\n                        <\/a:msup>\n                     <\/a:math>\n                  <\/jats:inline-formula>magnetic resonance imaging (MRI). Transfusion-dependent thalassemic (TDT) outpatients (n\u2009=\u200966; mean age, 21.5\u2009\u00b1\u20097.2\u2009years) were carried out for the complete assessment consisting of blood test including liver enzyme and serum ferritin, followed by electrocardiography (ECG) and echocardiography. Subjects were also divided by serum ferritin levels into three groups: &lt; 2500\u2009ng\/mL, 2500\u20135000\u2009ng\/mL, and &gt;5000\u2009ng\/mL. Additionally, subgroup analysis in patients with T2\u2217 MRI assessment was conducted. In terms of age of first blood transfusion, subjects with ferritin &gt;5000\u2009ng\/mL were the youngest among others. The alanine aminotransferase (ALT) levels in group with serum ferritin &gt;5000\u2009ng\/mL were significantly higher than those of the group with serum ferritin &lt;2500\u2009ng\/mL. Additionally, youth and adult TDT patients whose serum ferritin &gt;5000\u2009ng\/mL had significantly lower tricuspid annular plane systolic excursion (TAPSE) when compared with those who had serum ferritin &lt;2500\u2009ng\/mL. Similarly, TAPSE in patients with moderate cardiac siderosis based on cardiac T2\u2217 MRI was significantly lower than those without cardiac siderosis. There was significant, but only moderate correlation between serum ferritin and cardiac T2\u2217 MRI. Based on these findings, it is important to routinely monitor iron accumulation-related complications, including liver and cardiac damage in youth and adult TDT patients.<\/jats:p>","DOI":"10.1155\/2021\/5581831","type":"journal-article","created":{"date-parts":[[2021,4,16]],"date-time":"2021-04-16T00:35:38Z","timestamp":1618533338000},"page":"1-8","source":"Crossref","is-referenced-by-count":9,"title":["Iron Overload in Transfusion-Dependent Indonesian Thalassemic Patients"],"prefix":"10.1155","volume":"2021","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4487-6800","authenticated-orcid":true,"given":"Pandji Irani","family":"Fianza","sequence":"first","affiliation":[{"name":"Department of Internal Medicine, Division of Hematology and Medical Oncology, Faculty of Medicine, Universitas Padjadjaran\/Hasan Sadikin General Hospital, Bandung, West Java, Indonesia"},{"name":"Research Center of Medical Genetics, Faculty of Medicine, Universitas Padjadjaran, Bandung, West Java, Indonesia"},{"name":"Doctoral Study Program, Faculty of Medicine, Universitas Padjadjaran, Bandung, West Java, Indonesia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9346-2041","authenticated-orcid":true,"given":"Anita","family":"Rahmawati","sequence":"additional","affiliation":[{"name":"Research Center of Medical Genetics, Faculty of Medicine, Universitas Padjadjaran, Bandung, West Java, Indonesia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sri Hudaya","family":"Widihastha","sequence":"additional","affiliation":[{"name":"Research Center of Medical Genetics, Faculty of Medicine, Universitas Padjadjaran, Bandung, West Java, Indonesia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shofura","family":"Afifah","sequence":"additional","affiliation":[{"name":"Research Center of Medical Genetics, Faculty of Medicine, Universitas Padjadjaran, Bandung, West Java, Indonesia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9392-8374","authenticated-orcid":true,"given":"Mohammad","family":"Ghozali","sequence":"additional","affiliation":[{"name":"Research Center of Medical Genetics, Faculty of Medicine, Universitas Padjadjaran, Bandung, West Java, Indonesia"},{"name":"Department of Biomedical Sciences, Faculty of Medicine, Universitas Padjadjaran, Bandung, West Java, Indonesia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andre","family":"Indrajaya","sequence":"additional","affiliation":[{"name":"Research Center of Medical Genetics, Faculty of Medicine, Universitas Padjadjaran, Bandung, West Java, Indonesia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dilli Marayuzan Akbar","family":"Pratama","sequence":"additional","affiliation":[{"name":"Research Center of Medical Genetics, Faculty of Medicine, Universitas Padjadjaran, Bandung, West Java, Indonesia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dimmy","family":"Prasetya","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Division of Hematology and Medical Oncology, Faculty of Medicine, Universitas Padjadjaran\/Hasan Sadikin General Hospital, Bandung, West Java, Indonesia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6259-8429","authenticated-orcid":true,"given":"Teddy Arnold","family":"Sihite","sequence":"additional","affiliation":[{"name":"Department of Cardiology and Vascular Medicine, Faculty of Medicine, Universitas Padjadjaran\/Hasan Sadikin General Hospital, Bandung, West Java, Indonesia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0452-4157","authenticated-orcid":true,"given":"Mas Rizky A. A.","family":"Syamsunarno","sequence":"additional","affiliation":[{"name":"Research Center of Medical Genetics, Faculty of Medicine, Universitas Padjadjaran, Bandung, West Java, Indonesia"},{"name":"Department of Biomedical Sciences, Faculty of Medicine, Universitas Padjadjaran, Bandung, West Java, Indonesia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7488-4377","authenticated-orcid":true,"given":"Djatnika","family":"Setiabudi","sequence":"additional","affiliation":[{"name":"Department of Child Health, Faculty of Medicine, Universitas Padjadjaran\/Hasan Sadikin General Hospital, Bandung, West Java, Indonesia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6219-9711","authenticated-orcid":true,"given":"Suthat","family":"Fucharoen","sequence":"additional","affiliation":[{"name":"Thalassemia Research Center, Institute of Molecular Biosciences, Mahidol University, Nakhonpathom, Thailand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ramdan","family":"Panigoro","sequence":"additional","affiliation":[{"name":"Research Center of Medical Genetics, Faculty of Medicine, Universitas Padjadjaran, Bandung, West Java, Indonesia"},{"name":"Department of Biomedical Sciences, Faculty of Medicine, Universitas Padjadjaran, Bandung, West Java, Indonesia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.1056\/nejmra050436"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.1038\/gim.2016.173"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.22631\/ijbmph.2018.56102"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.12688\/f1000research.12688.1"},{"key":"5","doi-asserted-by":"publisher","DOI":"10.1111\/bjh.13374"},{"key":"6","doi-asserted-by":"publisher","DOI":"10.3109\/03630260903346627"},{"key":"7","doi-asserted-by":"publisher","DOI":"10.1007\/s00702-010-0479-3"},{"key":"8","first-page":"678","article-title":"Complications in transfusion-dependent patients of \u03b2-thalassemia major: a review","volume":"25","author":"S. 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