{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,4]],"date-time":"2025-12-04T17:10:48Z","timestamp":1764868248460,"version":"3.46.0"},"reference-count":21,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2021,5,18]],"date-time":"2021-05-18T00:00:00Z","timestamp":1621296000000},"content-version":"vor","delay-in-days":137,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Case Reports in Pediatrics"],"published-print":{"date-parts":[[2021,1]]},"abstract":"<jats:p>\n                    <jats:italic>Background<\/jats:italic>\n                    . Methemoglobinemia is a potentially life\u2010threatening condition which presents with cyanosis and characteristic \u201cchocolate\u2010coloured blood.\u201d Although a co\u2010oximetry would give a prompt diagnosis, there have been multiple reports of misdiagnosing this treatable condition\u2014from being diagnosed as sepsis to asthma and even being operated for \u201cruptured ectopic pregnancy.\u201d Here, we report a case which presented without the classical signs of poisoning and methemoglobinemia\u2014without vomiting, cyanosis, or chocolate\u2010coloured blood. We also discuss the common misconceptions regarding anemia physiology and the pitfalls in diagnosing this condition and warn the reader regarding the reflexive use of antidotes like methylene blue.\n                    <jats:italic>Case Presentation.<\/jats:italic>\n                    A well\u2010grown 3\u2010year old boy presented with an acute history of irritability, cola\u2010coloured urine, and desaturation on examination. The child was pale, with tachypnoea and in failure. Blood smear was suggestive of severe hemolytic anemia. Methemoglobinemia was diagnosed on co\u2010oximetry. By focussing on physiologic principles of management rather than a specific antidote, the child was discharged home, well and active within 3 days of intensive care admission.\n                  <\/jats:p>","DOI":"10.1155\/2021\/5583840","type":"journal-article","created":{"date-parts":[[2021,5,18]],"date-time":"2021-05-18T22:20:23Z","timestamp":1621376423000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Anemia That Presented with Desaturation: A Focus on Core Concepts"],"prefix":"10.1155","volume":"2021","author":[{"given":"Lakshmi","family":"Shobhavat","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4217-7184","authenticated-orcid":false,"given":"Antonio","family":"D\u2019Costa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karthik","family":"Shroff","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2021,5,18]]},"reference":[{"key":"e_1_2_8_1_2","doi-asserted-by":"publisher","DOI":"10.4274\/cayd.30602"},{"key":"e_1_2_8_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.rmcr.2012.08.002"},{"key":"e_1_2_8_3_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-6576.2005.00640.x"},{"key":"e_1_2_8_4_2","doi-asserted-by":"publisher","DOI":"10.4103\/ija.IJA_422_17"},{"key":"e_1_2_8_5_2","first-page":"58","article-title":"Methaemoglobinaemia in areas with high nitrate concentration in drinking water","volume":"13","author":"Gupta S. 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