{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,13]],"date-time":"2025-10-13T09:16:32Z","timestamp":1760346992733,"version":"3.41.2"},"reference-count":26,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2021,5,4]],"date-time":"2021-05-04T00:00:00Z","timestamp":1620086400000},"content-version":"vor","delay-in-days":123,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["BioMed Research International"],"published-print":{"date-parts":[[2021,1]]},"abstract":"<jats:p><jats:italic>Background<\/jats:italic>. Fibrinogen and interleukin\u20101<jats:italic>\u03b2<\/jats:italic> as a proinflammatory cytokine and interleukin\u201010 and nesfatin\u20101 as an anti\u2010inflammatory cytokine have an important role in the development and prevention of systemic inflammation and incidence of obesity\u2010induced diseases. Thus, this study is aimed at the interaction effects of aerobic training and oak husk hydroalcoholic extract consumption on plasma levels of fibrinogen, interleukin\u20101<jats:italic>\u03b2<\/jats:italic>, nesfatin\u20101, and interleukin\u201010 in obese elderly male mice. <jats:italic>Materials and Methods<\/jats:italic>. In this experimental study, 40 fat male mice were fed a high\u2010fat diet for 4 weeks to induce obesity, and subsequently, they were divided randomly into four groups: control, supplement, exercise\u2010placebo, and exercise\u2010supplement. The training groups performed aerobic exercise 5 days a week for 6 weeks (approximately 80\u201075% ). The supplement groups received a solution of oak husk hydroalcoholic extract at a dose of 20 milligram per kilogram of body weight for 6 weeks. Blood samples were taken 48\u2009h after the last training session, and the levels of IL\u201010, fibrinogen, IL\u20101<jats:italic>\u03b2<\/jats:italic>, and nesfatin\u20101 were measured. Data were analyzed using one\u2010way ANOVA and LSD post hoc tests. <jats:italic>Results<\/jats:italic>. The results showed that six\u2010week training and oak husk hydroalcoholic extract consumption significantly increased the levels of IL\u201010 and nesfatin\u20101 in experimental groups (<jats:italic>P<\/jats:italic> &lt; 0.001). Also, the levels of fibrinogen and IL\u20101<jats:italic>\u03b2<\/jats:italic> decreased significantly in training groups. Averages between group variations of all indicators were statistically significant, and they were more meaningfully pronounced in the exercise\u2010supplement group than other groups (<jats:italic>P<\/jats:italic> \u2264 0.05). <jats:italic>Conclusions<\/jats:italic>. Considering the results of the present study, the use of moderate aerobic exercise and oak husk hydroalcoholic extract is recommended to reduce the risk of obesity; it may also have a positive effect on inflammatory factors.<\/jats:p>","DOI":"10.1155\/2021\/5585077","type":"journal-article","created":{"date-parts":[[2021,5,4]],"date-time":"2021-05-04T19:42:49Z","timestamp":1620157369000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Therapeutic Efficacy of Aerobic Exercise Training along with Oak Husk Hydroalcoholic Extract for Amelioration of Inflammation in Obese Elderly Male 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