{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T19:58:19Z","timestamp":1792180699875,"version":"4.4.0"},"reference-count":26,"publisher":"Wiley","license":[{"start":{"date-parts":[[2021,3,31]],"date-time":"2021-03-31T00:00:00Z","timestamp":1617148800000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"CAMS Innovation Fund for Medical Sciences","award":["2016-I2M-1-001"],"award-info":[{"award-number":["2016-I2M-1-001"]}]},{"name":"CAMS Innovation Fund for Medical Sciences","award":["LC2018L05"],"award-info":[{"award-number":["LC2018L05"]}]},{"name":"CAMS Innovation Fund for Medical Sciences","award":["ZZ201914005"],"award-info":[{"award-number":["ZZ201914005"]}]},{"name":"CAMS Innovation Fund for Medical Sciences","award":["JJ2018-96"],"award-info":[{"award-number":["JJ2018-96"]}]},{"name":"Wang Xuan Fund of Jiu-San Society, Cancer Hospital Marathon Fund","award":["2016-I2M-1-001"],"award-info":[{"award-number":["2016-I2M-1-001"]}]},{"name":"Wang Xuan Fund of Jiu-San Society, Cancer Hospital Marathon Fund","award":["LC2018L05"],"award-info":[{"award-number":["LC2018L05"]}]},{"name":"Wang Xuan Fund of Jiu-San Society, Cancer Hospital Marathon Fund","award":["ZZ201914005"],"award-info":[{"award-number":["ZZ201914005"]}]},{"name":"Wang Xuan Fund of Jiu-San Society, Cancer Hospital Marathon Fund","award":["JJ2018-96"],"award-info":[{"award-number":["JJ2018-96"]}]},{"name":"Fundamental Research Funds for the Central Public Welfare Research Institutes","award":["2016-I2M-1-001"],"award-info":[{"award-number":["2016-I2M-1-001"]}]},{"name":"Fundamental Research Funds for the Central Public Welfare Research Institutes","award":["LC2018L05"],"award-info":[{"award-number":["LC2018L05"]}]},{"name":"Fundamental Research Funds for the Central Public Welfare Research Institutes","award":["ZZ201914005"],"award-info":[{"award-number":["ZZ201914005"]}]},{"name":"Fundamental Research Funds for the Central Public Welfare Research Institutes","award":["JJ2018-96"],"award-info":[{"award-number":["JJ2018-96"]}]},{"name":"Beijing TCM Science and Technology Development Fund Project","award":["2016-I2M-1-001"],"award-info":[{"award-number":["2016-I2M-1-001"]}]},{"name":"Beijing TCM Science and Technology Development Fund Project","award":["LC2018L05"],"award-info":[{"award-number":["LC2018L05"]}]},{"name":"Beijing TCM Science and Technology Development Fund Project","award":["ZZ201914005"],"award-info":[{"award-number":["ZZ201914005"]}]},{"name":"Beijing TCM Science and Technology Development Fund Project","award":["JJ2018-96"],"award-info":[{"award-number":["JJ2018-96"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Evidence-Based Complementary and Alternative Medicine"],"published-print":{"date-parts":[[2021,3,31]]},"abstract":"<jats:p>The effect of perioperative acupuncture on accelerating gastrointestinal function recovery has been reported in colorectal surgery and distal gastrectomy (Billroth-II). However, the evidence in pancreatectomy and other gastrectomy is still limited. A prospective, randomized controlled trial was conducted between May 2018 and August 2019. Consecutive patients undergoing pancreatectomy or gastrectomy in our hospital were randomly assigned to the electroacupuncture (EA) group and the control group. The patients in the EA group received transcutaneous EA on Bai-hui (GV20), Nei-guan (PC6), Tian-shu (ST25), and Zu-san-li (ST36) once a day in the afternoon, and the control group received sham EA. Primary outcomes were the time to first flatus and time to first defecation. In total, 461 patients were randomly assigned to the groups, and 385 were analyzed finally (EA group, n\u2009=\u2009201; control group, n\u2009=\u2009184). Time to first flatus (3.0\u2009\u00b1\u20090.7 vs 4.2\u2009\u00b1\u20091.0, <jats:inline-formula>\n                     <a:math xmlns:a=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M1\">\n                        <a:mi>P<\/a:mi>\n                        <a:mo>&lt;<\/a:mo>\n                        <a:mn>0.001<\/a:mn>\n                     <\/a:math>\n                  <\/jats:inline-formula>) and first defecation (4.2\u2009\u00b1\u20090.9 vs 5.4\u2009\u00b1\u20091.2, <jats:inline-formula>\n                     <c:math xmlns:c=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M2\">\n                        <c:mi>P<\/c:mi>\n                        <c:mo>&lt;<\/c:mo>\n                        <c:mn>0.001<\/c:mn>\n                     <\/c:math>\n                  <\/jats:inline-formula>) in the EA group were significantly shorter than those in the control group. Of patients undergoing pancreatectomy, those undergoing pancreaticoduodenectomy and intraoperative radiation therapy (IORT) surgery benefitted from EA in time to first flatus (<jats:inline-formula>\n                     <e:math xmlns:e=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M3\">\n                        <e:mi>P<\/e:mi>\n                        <e:mo>&lt;<\/e:mo>\n                        <e:mn>0.001<\/e:mn>\n                     <\/e:math>\n                  <\/jats:inline-formula>) and first defecation (<jats:inline-formula>\n                     <g:math xmlns:g=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M4\">\n                        <g:mi>P<\/g:mi>\n                        <g:mo>&lt;<\/g:mo>\n                        <g:mn>0.001<\/g:mn>\n                     <\/g:math>\n                  <\/jats:inline-formula>), while those undergoing distal pancreatectomy did not (<jats:inline-formula>\n                     <i:math xmlns:i=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M5\">\n                        <i:msub>\n                           <i:mrow>\n                              <i:mi>P<\/i:mi>\n                           <\/i:mrow>\n                           <i:mrow>\n                              <i:mtext>flatus<\/i:mtext>\n                           <\/i:mrow>\n                        <\/i:msub>\n                        <i:mo>=<\/i:mo>\n                        <i:mn>0.157<\/i:mn>\n                     <\/i:math>\n                  <\/jats:inline-formula>, <jats:inline-formula>\n                     <k:math xmlns:k=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M6\">\n                        <k:msub>\n                           <k:mrow>\n                              <k:mi>P<\/k:mi>\n                           <\/k:mrow>\n                           <k:mrow>\n                              <k:mtext>defecation<\/k:mtext>\n                           <\/k:mrow>\n                        <\/k:msub>\n                        <k:mo>=<\/k:mo>\n                        <k:mn>0.007<\/k:mn>\n                     <\/k:math>\n                  <\/jats:inline-formula>) completely. Of patients undergoing gastrectomy, those undergoing total gastrectomy and distal gastrectomy (Billroth-II) benefitted from EA (<jats:inline-formula>\n                     <m:math xmlns:m=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M7\">\n                        <m:mi>P<\/m:mi>\n                        <m:mo>&lt;<\/m:mo>\n                        <m:mn>0.001<\/m:mn>\n                     <\/m:math>\n                  <\/jats:inline-formula>), as did those undergoing proximal gastrectomy (<jats:inline-formula>\n                     <o:math xmlns:o=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M8\">\n                        <o:mi>P<\/o:mi>\n                        <o:mo>=<\/o:mo>\n                        <o:mn>0.015<\/o:mn>\n                     <\/o:math>\n                  <\/jats:inline-formula>). Patients undergoing distal gastrectomy (Billroth-I) benefitted from EA in time to first defecation (<jats:inline-formula>\n                     <q:math xmlns:q=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M9\">\n                        <q:mi>P<\/q:mi>\n                        <q:mo>=<\/q:mo>\n                        <q:mn>0.012<\/q:mn>\n                     <\/q:math>\n                  <\/jats:inline-formula>) but not flatus (<jats:inline-formula>\n                     <s:math xmlns:s=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M10\">\n                        <s:mi>P<\/s:mi>\n                        <s:mo>=<\/s:mo>\n                        <s:mn>0.051<\/s:mn>\n                     <\/s:math>\n                  <\/jats:inline-formula>). The time of parenteral nutrition, hospital stay, and time to first independent walk in the EA group were shorter than those in the control group. No severe EA complications were reported. EA was safe and effective in accelerating postoperative gastrointestinal function recovery. Patients undergoing pancreaticoduodenectomy, IORT surgery, total gastrectomy, proximal gastrectomy, or distal gastrectomy (Billroth-II) could benefit from EA. This trial is registered with NCT03291574.<\/jats:p>","DOI":"10.1155\/2021\/5594263","type":"journal-article","created":{"date-parts":[[2021,3,31]],"date-time":"2021-03-31T21:20:22Z","timestamp":1617225622000},"page":"1-11","source":"Crossref","is-referenced-by-count":20,"title":["Perioperative Electroacupuncture Can Accelerate the Recovery of Gastrointestinal Function in Cancer Patients Undergoing Pancreatectomy or Gastrectomy: A Randomized Controlled Trial"],"prefix":"10.1155","volume":"2021","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3009-1532","authenticated-orcid":true,"given":"Guotong","family":"Qiu","sequence":"first","affiliation":[{"name":"State Key Lab of Molecular Oncology and Department of Pancreatic and Gastric Surgery, National Cancer Center, National Clinical Research Center for Cancer\/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1600-1986","authenticated-orcid":true,"given":"Tao","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Acupuncture and Moxibustion Hospital of China Academy of Chinese Medicine Science, Beijing 100700, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yang","family":"Lu","sequence":"additional","affiliation":[{"name":"Graduate School, Liaoning University of Traditional Chinese Medicine, Shenyang 110847, Liaoning, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5204-6383","authenticated-orcid":true,"given":"Lipeng","family":"Zhang","sequence":"additional","affiliation":[{"name":"State Key Lab of Molecular Oncology and Department of Pancreatic and Gastric Surgery, National Cancer Center, National Clinical Research Center for Cancer\/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yajie","family":"Zhao","sequence":"additional","affiliation":[{"name":"State Key Lab of Molecular Oncology and Department of Pancreatic and Gastric Surgery, National Cancer Center, National Clinical Research Center for Cancer\/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yong","family":"Yuan","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Acupuncture and Moxibustion Hospital of China Academy of Chinese Medicine Science, Beijing 100700, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7274-287X","authenticated-orcid":true,"given":"Hu","family":"Ren","sequence":"additional","affiliation":[{"name":"State Key Lab of Molecular Oncology and Department of Pancreatic and Gastric Surgery, National Cancer Center, National Clinical Research Center for Cancer\/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"An","sequence":"additional","affiliation":[{"name":"Donggaodi Community Health Service Station, Beijing 100076, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jincao","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Acupuncture and Moxibustion Hospital of China Academy of Chinese Medicine Science, Beijing 100700, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rongjun","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Acupuncture and Moxibustion Hospital of China Academy of Chinese Medicine Science, Beijing 100700, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yongxing","family":"Du","sequence":"additional","affiliation":[{"name":"State Key Lab of Molecular Oncology and Department of Pancreatic and Gastric Surgery, National Cancer Center, National Clinical Research Center for Cancer\/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tuoran","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Acupuncture and Moxibustion Hospital of China Academy of Chinese Medicine Science, Beijing 100700, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peng","family":"Wang","sequence":"additional","affiliation":[{"name":"State Key Lab of Molecular Oncology and Department of Pancreatic and Gastric Surgery, National Cancer Center, National Clinical Research Center for Cancer\/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fang","family":"He","sequence":"additional","affiliation":[{"name":"State Key Lab of Molecular Oncology and Department of Pancreatic and Gastric Surgery, National Cancer Center, National Clinical Research Center for Cancer\/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yunqing","family":"Ding","sequence":"additional","affiliation":[{"name":"Graduate School, Liaoning University of Traditional Chinese Medicine, Shenyang 110847, Liaoning, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianwei","family":"Zhang","sequence":"additional","affiliation":[{"name":"State Key Lab of Molecular Oncology and Department of Pancreatic and Gastric Surgery, National Cancer Center, National Clinical Research Center for Cancer\/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bin","family":"Han","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Acupuncture and Moxibustion Hospital of China Academy of Chinese Medicine Science, Beijing 100700, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhongmin","family":"Lan","sequence":"additional","affiliation":[{"name":"State Key Lab of Molecular Oncology and Department of Pancreatic and Gastric Surgery, National Cancer Center, National Clinical Research Center for Cancer\/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shulan","family":"Qi","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Acupuncture and Moxibustion Hospital 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Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuemin","family":"Sun","sequence":"additional","affiliation":[{"name":"State Key Lab of Molecular Oncology and Department of Pancreatic and Gastric Surgery, National Cancer Center, National Clinical Research Center for Cancer\/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaofeng","family":"Bai","sequence":"additional","affiliation":[{"name":"State Key Lab of Molecular Oncology and Department of Pancreatic and Gastric Surgery, National Cancer Center, National Clinical Research Center for Cancer\/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saderbieke","family":"Aimaiti","sequence":"additional","affiliation":[{"name":"State Key Lab of Molecular Oncology and Department of Pancreatic and Gastric Surgery, National Cancer Center, National Clinical Research Center for Cancer\/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yunmian","family":"Chu","sequence":"additional","affiliation":[{"name":"State Key Lab of Molecular Oncology and Department of Pancreatic and Gastric Surgery, National Cancer Center, National Clinical Research Center for Cancer\/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5589-7391","authenticated-orcid":true,"given":"Chengfeng","family":"Wang","sequence":"additional","affiliation":[{"name":"State Key Lab of Molecular Oncology and Department of Pancreatic and Gastric Surgery, National Cancer Center, National Clinical Research Center for Cancer\/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, 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Medrano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2021,3,31]]},"references-count":26,"alternative-id":["5594263","5594263"],"URL":"https:\/\/doi.org\/10.1155\/2021\/5594263","relation":{},"ISSN":["1741-4288","1741-427X"],"issn-type":[{"value":"1741-4288","type":"electronic"},{"value":"1741-427X","type":"print"}],"subject":[],"published":{"date-parts":[[2021,3,31]]}}}