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We determined here whether emollient can direct inhibit cutaneous inflammation. Ear inflammation was induced by topical application of either 12\u2010O\u2010tetradecanoylphorbol\u201013\u2010acetate (TPA) or 1\u2010fluoro\u20102,4\u2010dinitrofluorobenzene (DNFB). Either 1% hydrocortisone cream or the novel emollient was applied to the right ear of the mice 45\u2009min and 2 hours after TPA or DNFB application. The untreated left ear served as untreated controls. Both ear weight and ear thickness were measured 24 hours after TPA and DNFB application. Topical applications of either hydrocortisone cream or emollient significantly decreased both ear thickness and ear weight in comparison to untreated controls. In DNFB model, hydrocortisone significantly lowered expression levels of mRNA for IL\u20101<jats:italic>\u03b1<\/jats:italic>, IL\u20101<jats:italic>\u03b2<\/jats:italic>, and TNF<jats:italic>\u03b1<\/jats:italic>, while the emollient markedly decreased expression levels of IL\u20101<jats:italic>\u03b1<\/jats:italic> and TNF<jats:italic>\u03b1<\/jats:italic> mRNA. In TPA model, both hydrocortisone and emollient significantly decreased expression levels of IL\u20101<jats:italic>\u03b1<\/jats:italic>, IL\u20101<jats:italic>\u03b2<\/jats:italic>, IL\u20106, and TNF<jats:italic>\u03b1<\/jats:italic> mRNA. In parallel, inflammatory infiltration was also reduced by topical applications of either hydrocortisone or emollient. These results demonstrate that this novel emollient can directly inhibit cutaneous inflammation in murine models of both acute irritant contact dermatitis and acute allergic contact dermatitis. However, whether this emollient could also alleviate eczematous dermatitis in humans remains to be explored.<\/jats:p>","DOI":"10.1155\/2021\/5594646","type":"journal-article","created":{"date-parts":[[2021,4,13]],"date-time":"2021-04-13T19:57:54Z","timestamp":1618343874000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Topical Applications of a Novel Emollient Inhibit Inflammation in Murine Models of Acute Contact Dermatitis"],"prefix":"10.1155","volume":"2021","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5115-0696","authenticated-orcid":false,"given":"Si","family":"Wen","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2305-2693","authenticated-orcid":false,"given":"Mengke","family":"Sun","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7834-9048","authenticated-orcid":false,"given":"Li","family":"Ye","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7155-6079","authenticated-orcid":false,"given":"Bin","family":"Yang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2933-2207","authenticated-orcid":false,"given":"Lizhi","family":"Hu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0957-4903","authenticated-orcid":false,"given":"Mao-Qiang","family":"Man","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2021,4,13]]},"reference":[{"key":"e_1_2_10_1_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2013.08.031"},{"key":"e_1_2_10_2_2","doi-asserted-by":"publisher","DOI":"10.3109\/02813432.2016.1160629"},{"key":"e_1_2_10_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(19)32983-6"},{"key":"e_1_2_10_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(19)32984-8"},{"key":"e_1_2_10_5_2","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.15786"},{"key":"e_1_2_10_6_2","first-page":"589","article-title":"Steroid-free emollient formulations reduce symptoms of eczema and improve quality of life","volume":"13","author":"Weber T. 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