{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,15]],"date-time":"2026-07-15T08:07:52Z","timestamp":1784102872380,"version":"3.55.0"},"reference-count":50,"publisher":"Wiley","license":[{"start":{"date-parts":[[2021,10,19]],"date-time":"2021-10-19T00:00:00Z","timestamp":1634601600000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004320","name":"Shiraz University of Medical Sciences","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004320","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Evidence-Based Complementary and Alternative Medicine"],"published-print":{"date-parts":[[2021,10,19]]},"abstract":"<jats:p>Purpose. The high prevalence of knee osteoarthritis (KOA) is a major cause of disability among elders. NSAIDs are recommended to reduce KOA patients\u2019 symptoms, but their adverse side effects limit their consumption. In this study, we evaluated the effectiveness of Harpagophytum procumbens compared to a routine NSAID (meloxicam) on pain reduction and functional improvement of KOA patients. Patients and Methods. Sixty patients aged 40\u201360 years, with painful knee osteoarthritis (grades 1-2 of Kellgren\u2013Lawrence scale) for at least one month, were randomized into two groups with different routine medication periods. Group A consisted of daily administration of two Harpagophytum procumbens (Teltonal) tablets (2<jats:inline-formula>\n                     <a:math xmlns:a=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M1\">\n                        <a:mi>\u2217<\/a:mi>\n                     <\/a:math>\n                  <\/jats:inline-formula>480\u2009mg) for one month, and group B consisted of daily administration of meloxicam (15\u2009mg) for ten days. The visual analogue scale (VAS), Western Ontario McMaster University Osteoarthritis Index (WOMAC), Oxford Knee Scale (OKS), and patient satisfaction were evaluated at the baseline and after 2, 4, and 8 weeks. Results. There were no statistically significant differences between demographic characteristics, pain intensity, and function scores before the treatment. VAS, OKS, and WOMAC scores improved in both groups <jats:inline-formula>\n                     <c:math xmlns:c=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M2\">\n                        <c:mfenced open=\"(\" close=\")\" separators=\"|\">\n                           <c:mrow>\n                              <c:mi>p<\/c:mi>\n                              <c:mo>&lt;<\/c:mo>\n                              <c:mn>0.001<\/c:mn>\n                           <\/c:mrow>\n                        <\/c:mfenced>\n                     <\/c:math>\n                  <\/jats:inline-formula> over time, but no significant superiority was shown; after 8 weeks: VAS (Teltonal (4.80\u2009\u00b1\u20091.80) vs. meloxicam (5.06\u2009\u00b1\u20091.43)), OKS (34.06\u2009\u00b1\u20094.38, 34.00\u2009\u00b1\u20097.87, Teltonal vs. meloxicam, respectively), and WOMAC scores (25.73\u2009\u00b1\u200910.11 Teltonal vs. 26.20\u2009\u00b1\u200913.94, meloxicam). Conclusion. Teltonal is an effective and safe treatment in patients with mild KOA in the short term. However, no significant superiority was shown in using Teltonal or meloxicam, in people who cannot take NSAIDs, it can be a good alternative, although difference in medication periods should be considered.<\/jats:p>","DOI":"10.1155\/2021\/5596892","type":"journal-article","created":{"date-parts":[[2021,10,20]],"date-time":"2021-10-20T09:24:26Z","timestamp":1634721866000},"page":"1-8","source":"Crossref","is-referenced-by-count":18,"title":["The Efficacy of Harpagophytum procumbens (Teltonal) in Patients with Knee Osteoarthritis: A Randomized Active-Controlled Clinical Trial"],"prefix":"10.1155","volume":"2021","author":[{"given":"Hamid Reza","family":"Farpour","sequence":"first","affiliation":[{"name":"Bone and Joint Diseases Research Center, Department of Physical Medicine and Rehabilitation, Shiraz University of Medical Sciences, Shiraz, Iran"},{"name":"Shiraz Geriatric Research Center, Shiraz University of Medical Sciences, Shiraz, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Najme","family":"Rajabi","sequence":"additional","affiliation":[{"name":"Student Research Committee, Department of Physical Medicine and Rehabilitation, Shiraz University of Medical Sciences, Shiraz, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8959-8202","authenticated-orcid":true,"given":"Bahareh","family":"Ebrahimi","sequence":"additional","affiliation":[{"name":"Shiraz Geriatric Research Center, Shiraz University of Medical Sciences, Shiraz, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen-2019-031734"},{"key":"2","doi-asserted-by":"crossref","first-page":"1260","DOI":"10.1016\/S0140-6736(17)32130-X","article-title":"Global, regional, and national disability-adjusted life-years (dalys) for 333 diseases and injuries and healthy life expectancy (hale) for 195 countries and territories, 1990\u20132016: a systematic analysis for the global burden of disease study 2016","volume":"390","author":"S. 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