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These natural raw materials were blended with suitable dosages of gelatin and carboxymethyl cellulose (CMC) to produce a biocompatible herbal gel. The physical chemistry properties of the hydrogel were determined by Fourier transform infrared spectroscopy (FTIR), thermal gravimetric analysis (TGA), rheometry, and scanning electron microscopy (SEM), and the hydrogel showed good mechanical and morphological characteristics. The herbal extract\u2010loaded hydrogel mimicked extracellular matrix properties and showed good antioxidant and anti\u2010inflammatory properties and various advantages, serving as a potential wound dressing material because of its high moisture retention ability, wound exudate absorption behavior, and biocompatibility. It exhibited moderate\u2010high antioxidative and anti\u2010inflammatory qualities that were important for dermis wound closure. The clinical trial results showed that most patients experienced moderate to high healing rates, and four of twenty\u2010four individuals (16.67%) had recovery area ratios greater than 80%. This herbal extract\u2010loaded hydrogel has effective ingredients and excellent mechanical properties as a bioactive dressing agent for acne treatment.<\/jats:p>","DOI":"10.1155\/2021\/5598291","type":"journal-article","created":{"date-parts":[[2021,11,2]],"date-time":"2021-11-02T23:35:14Z","timestamp":1635896114000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":28,"title":["A Novel Biocompatible Herbal Extract\u2010Loaded Hydrogel for Acne Treatment and 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