{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,30]],"date-time":"2026-06-30T17:29:45Z","timestamp":1782840585092,"version":"3.54.5"},"reference-count":19,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2021,10,7]],"date-time":"2021-10-07T00:00:00Z","timestamp":1633564800000},"content-version":"vor","delay-in-days":279,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81871293"],"award-info":[{"award-number":["81871293"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Oxidative Medicine and Cellular Longevity"],"published-print":{"date-parts":[[2021,1]]},"abstract":"<jats:p>Concomitant exotropia have obvious symptoms of eye discomfort in adults, and the presence of ocular surface inflammation in patients may be important mediators between concomitant exotropia and dry eye. Oculus Keratograph eye comprehensive analyzer was performed to detect noninvasive tear break time, noninvasive tear height, and eye red index, while the ocular surface disease index and schirmer I testing were made. The levels of IL\u20106, IL\u201010, IL\u201017A, IL\u201012P70, INF\u2010<jats:italic>\u03b3<\/jats:italic>, and TNF\u2010<jats:italic>\u03b1<\/jats:italic> were detected in tears in patients with concomitant exotropia and healthy controls matched by age and gender through the Simoa technology. IL\u20106 was significantly higher in patients with concomitant exotropia (4.683 \u00b1 1.329) pg\/mL than that in normal group (1.455 \u00b1 0.391) pg\/mL, <jats:italic>p<\/jats:italic> = 0.0304. TNF\u2010<jats:italic>\u03b1<\/jats:italic> was also significantly higher in patients (0.2095 \u00b1 0.0703) pg\/mL than normal group (0.0513 \u00b1 0.0149) pg\/mL, <jats:italic>p<\/jats:italic> = 0.0397. The levels of inflammatory factors in strabismic patients vs. normal controls were as follows: IL\u201017A (0.1551\u2009pg\/mL\ufe300.0793\u2009pg\/mL), IL\u201010 (0.3358\u2009pg\/mL\ufe300.0513\u2009pg\/mL), IL\u201012p70 (0.0253\u2009pg\/mL\ufe300.0099\u2009pg\/mL), and INF\u2010<jats:italic>\u03b3<\/jats:italic> (0.0284\u2009pg\/mL\ufe300.009\u2009pg\/mL) were detected, and the median of them in concomitant strabismus was 1.96\u20106.55\u2010fold as much as the control group. High levels of inflammatory cytokines in tears of patients with concomitant exotropia, which may be a potentially factor promoted the occurrence of dry eye in the patients with concomitant exotropia.<\/jats:p>","DOI":"10.1155\/2021\/5662550","type":"journal-article","created":{"date-parts":[[2021,10,8]],"date-time":"2021-10-08T02:09:59Z","timestamp":1633658999000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["High Level of Inflammatory Cytokines in the Tears: A Bridge of Patients with Concomitant Exotropia and Dry 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