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Further molecular pathology studies may contribute to a comprehensive understanding of IPAH and provide new insights into diagnostic markers and potential therapeutic targets. Iron deficiency has been reported in 43\u201063% of patients with IPAH and is associated with reduced exercise capacity and higher mortality, suggesting that dysregulated iron metabolism may play an unrecognized role in influencing the development of IPAH. In this study, we explored the regulatory mechanisms of iron metabolism in IPAH by bioinformatic analysis. The molecular function of iron metabolism\u2010related genes (IMRGs) is mainly enriched in active transmembrane transporter activity, and they mainly affect the biological process of response to oxidative stress. Ferroptosis and fluid shear stress and atherosclerosis pathways may be the critical pathways regulating iron metabolism in IPAH. We further identified 7 key genes (BCL2, GCLM, MSMO1, SLC7A11, SRXN1, TSPAN5, and TXNRD1) and 5 of the key genes (BCL2, MSMO1, SLC7A11, TSPAN5, and TXNRD1) as target genes may be regulated by 6 dysregulated miRNAs (miR\u2010483\u20105p, miR\u201027a\u20103p, miR\u201027b\u20103p, miR\u201026b\u20105p, miR\u2010199a\u20105p, and miR\u201023b\u20103p) in IPAH. In addition, we predicted potential IPAH drugs\u2014celastrol and cinnamaldehyde\u2014that target iron metabolism based on our results. These results provide insights for further definition of the role of dysregulated iron metabolism in IPAH and contribute to a deeper understanding of the molecular mechanisms and potential therapeutic targets of IPAH.<\/jats:p>","DOI":"10.1155\/2021\/5669412","type":"journal-article","created":{"date-parts":[[2021,10,22]],"date-time":"2021-10-22T22:19:47Z","timestamp":1634941187000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":25,"title":["Iron Metabolism and Idiopathic Pulmonary Arterial Hypertension: New Insights from Bioinformatic 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