{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T02:40:43Z","timestamp":1747190443221,"version":"3.40.5"},"reference-count":35,"publisher":"Wiley","license":[{"start":{"date-parts":[[2021,10,18]],"date-time":"2021-10-18T00:00:00Z","timestamp":1634515200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Evidence-Based Complementary and Alternative Medicine"],"published-print":{"date-parts":[[2021,10,18]]},"abstract":"<jats:p>Background. Sedum dendroideum has antioxidant effects that are beneficial for different diseases. We aimed to analyze the antiproliferative activity of S. dendroideum in human pterygium fibroblasts (HPFs). Methods. HPFs were treated for 24\u2009h with 0\u20131000\u2009\u03bcg\/mL of S. dendroideum lyophilized to analyze its effect on cell viability using the CellTiter assay. RNA from HPF treated with 250\u2009\u03bcg\/mL of S. dendroideum lyophilized was isolated, and the expression of VEGF and CTGF genes was evaluated by qPCR. A dermal fibroblast cell line (HDFa) was used as a healthy control. The total phenolic content, antioxidant activity, and chemical profile of S. dendroideum lyophilized were determined. Results. Viability of HPF decreased after 24\u2009h treatment of S. dendroideum in a dose-dependent manner. The expression of VEGF and CTGF significantly decreased (<jats:inline-formula>\n                     <a:math xmlns:a=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M1\">\n                        <a:mi>P<\/a:mi>\n                        <a:mo>&lt;<\/a:mo>\n                        <a:mn>0.01<\/a:mn>\n                     <\/a:math>\n                  <\/jats:inline-formula>) in HPF treated with 250\u2009\u03bcg\/mL of S. dendroideum when compared with untreated HPF. The total phenolic concentration in the S. dendroideum lyophilized was 33.67\u2009mg gallic acid equivalents (GAE)\/g. Antioxidant activity was 384.49\u2009mM Trolox equivalents\/mL. The main phenolic compounds identified by HPLC analysis were the kaempferol-3-O-glycoside, kaempferol-3-O-rhamnoside, kaempferol-3-O-neohesperidoside-7-O-\u03b1-rhamnopyranoside, and kaempferol-3-O-glycoside-7-O-rhamnoside. Conclusions. S. dendroideum decreases the proliferation of HPF and the expression of VEGF and CTGF. The phenolic compound concentration, antioxidant activity, and phytochemical profile may play a role in these effects.<\/jats:p>","DOI":"10.1155\/2021\/5814221","type":"journal-article","created":{"date-parts":[[2021,10,19]],"date-time":"2021-10-19T21:01:18Z","timestamp":1634677278000},"page":"1-7","source":"Crossref","is-referenced-by-count":1,"title":["Phytochemical Profile and Antioxidant and Antiproliferative Activity of Sedum dendroideum on Pterygium Fibroblasts"],"prefix":"10.1155","volume":"2021","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9144-6574","authenticated-orcid":true,"given":"Paloma","family":"L\u00f3pez-Montemayor","sequence":"first","affiliation":[{"name":"Tecnologico de Monterrey, Escuela de Medicina, 3000 Morones Prieto Ave, Col. Los Doctores, C. 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