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Researchers are committed to building Wise Information Technology of 120 (WIT 120) for residents and medical personnel with the concept of simple smart medical care and through core technologies such as Internet of Things, Big Data Analytics, Artificial Intelligence, and microservice framework, to improve patient safety, medical quality, clinical efficiency, and operational benefits. Among them, how to use computers and deep learning technology to assist in the diagnosis of tongue images and realize intelligent tongue diagnosis has become a major trend. Tongue crack is an important feature of tongue states. Not only does change of tongue crack states reflect objectively and accurately changed circumstances of some typical diseases and TCM syndrome but also semantic segmentation of fissured tongue can combine the other features of tongue states to further improve tongue diagnosis systems\u2019 identification accuracy. Although computer tongue diagnosis technology has made great progress, there are few studies on the fissured tongue, and most of them focus on the analysis of tongue coating and body. In this paper, we do systematic and in-depth researches and propose an improved U-Net network for image semantic segmentation of fissured tongue. By introducing the Global Convolution Network module into the encoder part of U-Net, it solves the problem that the encoder part is relatively simple and cannot extract relatively abstract high-level semantic features. Finally, the method is verified by experiments. The improved U-Net network has a better segmentation effect and higher segmentation accuracy for fissured tongue image dataset. It can be used to design a computer-aided tongue diagnosis system.<\/jats:p>","DOI":"10.1155\/2021\/5853128","type":"journal-article","created":{"date-parts":[[2021,11,18]],"date-time":"2021-11-18T23:35:14Z","timestamp":1637278514000},"page":"1-15","source":"Crossref","is-referenced-by-count":16,"title":["Application of U-Net with Global Convolution Network Module in Computer-Aided Tongue Diagnosis"],"prefix":"10.1155","volume":"2021","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6319-8179","authenticated-orcid":true,"given":"Meng-Yi","family":"Li","sequence":"first","affiliation":[{"name":"School of Computer Science, South China Normal University, Guangzhou, Guangdong 510631, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2042-0814","authenticated-orcid":true,"given":"Ding-Ju","family":"Zhu","sequence":"additional","affiliation":[{"name":"School of Computer Science, South China Normal University, Guangzhou, Guangdong 510631, China"},{"name":"School of Geography, South China Normal University, Guangzhou, Guangdong 510631, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wen","family":"Xu","sequence":"additional","affiliation":[{"name":"General ICU of Lingnan Hospital, The Third Affiliated Hospital of Sun Yat Sen University, Guangzhou, Guangdong 510631, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu-Jie","family":"Lin","sequence":"additional","affiliation":[{"name":"Department of Traditional Chinese Medicine, Sun Yat Sen Memorial Hospital, Sun Yat Sen University, Guangzhou, Guangdong 510631, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9091-6140","authenticated-orcid":true,"given":"Kai-Leung","family":"Yung","sequence":"additional","affiliation":[{"name":"Department of Industrial and Systems Engineering, Hong Kong Polytechnic University, Hong Kong 999077, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6609-0713","authenticated-orcid":true,"given":"Andrew W. 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