{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,4]],"date-time":"2025-12-04T17:10:26Z","timestamp":1764868226183,"version":"3.46.0"},"reference-count":25,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2021,11,1]],"date-time":"2021-11-01T00:00:00Z","timestamp":1635724800000},"content-version":"vor","delay-in-days":304,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Case Reports in Pediatrics"],"published-print":{"date-parts":[[2021,1]]},"abstract":"<jats:p>\n                    <jats:italic>Introduction<\/jats:italic>\n                    . Down syndrome (DS) is one of the most frequent genomic disorders around the globe (\u223c1:700 births). During the COVID\u201019 pandemic, it has been recognized that children with DS are patients with a greater risk of presenting SARS\u2010CoV\u20102 infection\u2010related poor outcomes. Nonetheless, a few cases with DS and SARS\u2010CoV\u20102 infection have been reported. Our aim is to describe the unfavorable clinical course of a child with DS infected with SARS\u2010CoV\u20102 virus.\n                    <jats:italic>Case<\/jats:italic>\n                    . Female, 2 years old, karyotype 47,XX,+21[30], previously diagnosed with a cyanotic congenital heart disease (tricuspid atresia and infundibular pulmonary stenosis, type Ib) who started with diarrhea, developed shortness of breath, and cyanosis and was admitted to the hospital presenting low\u2010oxygen saturation (33%) requiring invasive mechanical ventilation support. The patient tested positive for SARS\u2010CoV\u20102 infection. During hospitalization, the patient presented hypotension, anuria, retarded capillary filling, and metabolic acidosis; management with vasoactive drugs was needed. Nonetheless, the patient developed respiratory and cardiac failure, acute renal injury (AKIN\u2010III), and septic shock. After 24 days of hospitalization, the patient died.\n                    <jats:italic>Conclusions<\/jats:italic>\n                    . Multiple organ failure observed in the patient presented could be related to the triple gene dose of four interferon receptors (\n                    <jats:italic>IFNAR1<\/jats:italic>\n                    ,\n                    <jats:italic>IFNAR2<\/jats:italic>\n                    ,\n                    <jats:italic>IFNGR2<\/jats:italic>\n                    , and\n                    <jats:italic>IL10RB<\/jats:italic>\n                    ) located at 21q22.11. Additionally, overexpression of\n                    <jats:italic>TMPRSS2<\/jats:italic>\n                    at the pulmonary level, located also at 21q22.3, could be related with an increased susceptibility for the development of SARS\u2010CoV\u20102 infection in DS patients.\n                  <\/jats:p>","DOI":"10.1155\/2021\/5893242","type":"journal-article","created":{"date-parts":[[2021,11,2]],"date-time":"2021-11-02T00:20:08Z","timestamp":1635812408000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Multiple Organ Failure Associated with SARS\u2010CoV\u20102 Infection in a Child with Down Syndrome: Is Trisomy 21 Associated with an Unfavourable Clinical Course?"],"prefix":"10.1155","volume":"2021","author":[{"given":"Perla Idalia","family":"Vazquez-Hern\u00e1ndez","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alan","family":"C\u00e1rdenas-Conejo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Manuel Alejandro","family":"Catal\u00e1n-Ruiz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karla","family":"Navar-Gallegos","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emilio","family":"Zenteno-Salazar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jose","family":"Rafael-Parra-Bravo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ranferi","family":"Aragon-Nogales","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maribel","family":"Ibarra-Sarlat","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8070-9727","authenticated-orcid":false,"given":"Juan Carlos","family":"N\u00fa\u00f1ez-Enr\u00edquez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2021,11]]},"reference":[{"key":"e_1_2_10_1_2","doi-asserted-by":"publisher","DOI":"10.1111\/apa.15409"},{"key":"e_1_2_10_2_2","doi-asserted-by":"publisher","DOI":"10.1001\/jamapediatrics.2020.2430"},{"key":"e_1_2_10_3_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrg.2016.154"},{"key":"e_1_2_10_4_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41572-019-0143-7"},{"key":"e_1_2_10_5_2","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2016-0123"},{"key":"e_1_2_10_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/s0300-8932(03)76978-4"},{"key":"e_1_2_10_7_2","doi-asserted-by":"publisher","DOI":"10.1097\/gim.0b013e3181634867"},{"key":"e_1_2_10_8_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12887-020-02471-5"},{"key":"e_1_2_10_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2020.08.067"},{"key":"e_1_2_10_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2020.06.076"},{"key":"e_1_2_10_11_2","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2017.00729"},{"key":"e_1_2_10_12_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41431-020-0696-7"},{"key":"e_1_2_10_13_2","doi-asserted-by":"publisher","DOI":"10.3201\/eid1608.091931"},{"key":"e_1_2_10_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.xcrm.2020.100019"},{"key":"e_1_2_10_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2020.02.052"},{"key":"e_1_2_10_16_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-021-81451-w"},{"key":"e_1_2_10_17_2","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2018.02683"},{"key":"e_1_2_10_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.vaccine.2015.10.083"},{"key":"e_1_2_10_19_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature03712"},{"key":"e_1_2_10_20_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrcardio.2014.59"},{"key":"e_1_2_10_21_2","doi-asserted-by":"publisher","DOI":"10.1038\/nm1267"},{"key":"e_1_2_10_22_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0235987"},{"key":"e_1_2_10_23_2","first-page":"4055","article-title":"microRNA-125b contributes to high glucose-induced reactive oxygen species generation and apoptosis in HK-2 renal tubular epithelial cells by targeting angiotensin-converting enzyme 2","volume":"20","author":"Huang Y. F.","year":"2016","journal-title":"European Review for Medical and Pharmacological Sciences"},{"key":"e_1_2_10_24_2","doi-asserted-by":"publisher","DOI":"10.3892\/br.2017.1019"},{"key":"e_1_2_10_25_2","doi-asserted-by":"publisher","DOI":"10.1101\/2020.11.03.20225359"}],"container-title":["Case Reports in Pediatrics"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/cripe\/2021\/5893242.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/cripe\/2021\/5893242.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1155\/2021\/5893242","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,4]],"date-time":"2025-12-04T17:05:58Z","timestamp":1764867958000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1155\/2021\/5893242"}},"subtitle":[],"editor":[{"given":"Ozgur","family":"Kasapcopur","sequence":"additional","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2021,1]]},"references-count":25,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2021,1]]}},"alternative-id":["10.1155\/2021\/5893242"],"URL":"https:\/\/doi.org\/10.1155\/2021\/5893242","archive":["Portico"],"relation":{},"ISSN":["2090-6803","2090-6811"],"issn-type":[{"type":"print","value":"2090-6803"},{"type":"electronic","value":"2090-6811"}],"subject":[],"published":{"date-parts":[[2021,1]]},"assertion":[{"value":"2021-08-09","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-10-13","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-11-01","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"5893242"}}