{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,21]],"date-time":"2026-04-21T19:07:00Z","timestamp":1776798420170,"version":"3.51.2"},"reference-count":29,"publisher":"Wiley","license":[{"start":{"date-parts":[[2021,11,5]],"date-time":"2021-11-05T00:00:00Z","timestamp":1636070400000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Zhejiang Preventive Medicine Association","award":["2017YF03"],"award-info":[{"award-number":["2017YF03"]}]},{"name":"Zhejiang Preventive Medicine Association","award":["20172090"],"award-info":[{"award-number":["20172090"]}]},{"name":"Science and Technology Bureau of Quzhou","award":["2017YF03"],"award-info":[{"award-number":["2017YF03"]}]},{"name":"Science and Technology Bureau of Quzhou","award":["20172090"],"award-info":[{"award-number":["20172090"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Immunology Research"],"published-print":{"date-parts":[[2021,11,5]]},"abstract":"<jats:p>Mumps is a vaccine-preventable disease caused by the mumps virus, but the incidence of mumps has increased among the children who were vaccinated with one-dose measles-mumps-rubella (MMR) in recent years. In this study, we analyzed the influence of different doses of mumps-containing vaccine (MuCV) against mumps using Cox-proportional hazard model. We collected 909 mumps cases of children who were born from 2006 to 2010 and vaccinated with different doses of MuCV in Quzhou during 2006-2018, which were all clinically diagnosed. Kaplan-Meier survival methods and Cox-proportional hazard model were used to estimate the hazard probabilities. Kaplan\u2013Meier curves showed that the cumulative hazard of male and female has no difference; lower hazards were detected among those who were vaccinated with two-dose MuCV, born in 2006, and infected after supplementary immunization activities (SIA). Cox-proportional hazard regression suggested that onset after SIA, born in 2006, and vaccinated with two-dose MuCV were protective factors against infection even after adjusting for potential confounding effects. Our study showed that it was necessary to revise the diagnostic criteria of mumps and identify RT-PCR as the standard for mumps diagnosis in China. We suggested that routine immunization schedule should introduce two doses of MMR and prevaccination screening should be performed before booster immunization in vaccinated populations.<\/jats:p>","DOI":"10.1155\/2021\/5990417","type":"journal-article","created":{"date-parts":[[2021,11,6]],"date-time":"2021-11-06T02:35:05Z","timestamp":1636166105000},"page":"1-8","source":"Crossref","is-referenced-by-count":9,"title":["Introduction of Two-Dose Mumps-Containing Vaccine into Routine Immunization Schedule in Quzhou, China, Using Cox-Proportional Hazard Model"],"prefix":"10.1155","volume":"2021","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7678-5989","authenticated-orcid":true,"given":"Zhiying","family":"Yin","sequence":"first","affiliation":[{"name":"Quzhou Center for Disease Control and Prevention, Quzhou, 324000 Zhejiang, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Canjie","family":"Zheng","sequence":"additional","affiliation":[{"name":"Quzhou Center for Disease Control and Prevention, Quzhou, 324000 Zhejiang, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Quanjun","family":"Fang","sequence":"additional","affiliation":[{"name":"Quzhou Center for Disease Control and Prevention, Quzhou, 324000 Zhejiang, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaoying","family":"Gong","sequence":"additional","affiliation":[{"name":"Quzhou Center for Disease Control and Prevention, Quzhou, 324000 Zhejiang, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guoping","family":"Cao","sequence":"additional","affiliation":[{"name":"Quzhou Center for Disease Control and Prevention, Quzhou, 324000 Zhejiang, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Junji","family":"Li","sequence":"additional","affiliation":[{"name":"Quzhou Center for Disease Control and Prevention, Quzhou, 324000 Zhejiang, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3179-3475","authenticated-orcid":true,"given":"Ziling","family":"Xiang","sequence":"additional","affiliation":[{"name":"Quzhou Center for Disease Control and Prevention, Quzhou, 324000 Zhejiang, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1244-4245","authenticated-orcid":true,"given":"Wei","family":"Song","sequence":"additional","affiliation":[{"name":"Quzhou Women & Children\u2019s Hospital, Quzhou, 324000 Zhejiang, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.1097\/01.JAA.0000532112.90755.41"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.1038\/srep46328"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.3390\/ijerph16020168"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.1186\/s12879-020-04956-1"},{"key":"5","doi-asserted-by":"publisher","DOI":"10.2807\/1560-7917.ES.2020.25.4.2000047"},{"key":"6","doi-asserted-by":"publisher","DOI":"10.1016\/j.coviro.2019.01.002"},{"key":"7","doi-asserted-by":"publisher","DOI":"10.1155\/2020\/8130760"},{"key":"8","article-title":"National Health and Family Planning Commission of the People\u2019s Republic of China","author":"Diagnostic criteria for mumps (WS270-2007)"},{"key":"9","doi-asserted-by":"publisher","DOI":"10.1128\/CVI.00542-16"},{"key":"10","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciw762"},{"key":"11","doi-asserted-by":"publisher","DOI":"10.3390\/ijerph15081618"},{"issue":"12","key":"12","first-page":"1018","article-title":"Laboratory confirmation of 139 clinical diagnosed breakthrough mumps cases","volume":"33","author":"B. 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