{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T03:25:04Z","timestamp":1792725904920,"version":"4.5.0"},"reference-count":50,"publisher":"Wiley","license":[{"start":{"date-parts":[[2021,9,21]],"date-time":"2021-09-21T00:00:00Z","timestamp":1632182400000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Computational and Mathematical Methods in Medicine"],"published-print":{"date-parts":[[2021,9,21]]},"abstract":"<jats:p>Hypoxic ischemic encephalopathy (HIE) is classified as a sort of serious nervous system syndrome that occurs in the early life period. Noncoding RNAs had been confirmed to have crucial roles in human diseases. So far, there were few systematical and comprehensive studies towards the expression profile of RNAs in the brain after hypoxia ischemia. In this study, 31 differentially expressed microRNAs (miRNAs) with upregulation were identified. In addition, 5512 differentially expressed mRNAs, long noncoding RNAs (lncRNAs), and circular RNAs (circRNAs) were identified in HIE groups. Bioinformatics analysis showed these circRNAs and mRNAs were significantly enriched in regulation of leukocyte activation, response to virus, and neutrophil degranulation. Pathway and its related gene network analysis indicated that HLA\u2009\u2212\u2009DPA1, HLA\u2009\u2212\u2009DQA2, HLA\u2009\u2212\u2009DQB1, and HLA\u2009\u2212\u2009DRB4 have a more crucial role in HIE. Finally, miRNA-circRNA-mRNA interaction network analysis was also performed to identify hub miRNAs and circRNAs. We found that miR-592 potentially targeting 5 circRNAs, thus affecting 15 mRNA expressions in HIR. hsa_circ_0068397 and hsa_circ_0045698 were identified as hub circRNAs in HIE. Collectively, using RNA-seq, bioinformatics analysis, and circRNA\/miRNA interaction prediction, we systematically investigated the differentially expressed RNAs in HIE, which could give a new hint of understanding the pathogenesis of HIE.<\/jats:p>","DOI":"10.1155\/2021\/6015473","type":"journal-article","created":{"date-parts":[[2021,9,22]],"date-time":"2021-09-22T18:54:14Z","timestamp":1632336854000},"page":"1-18","source":"Crossref","is-referenced-by-count":5,"title":["Comprehensive Analysis of RNA Expression Profile Identifies Hub miRNA-circRNA Interaction Networks in the Hypoxic Ischemic Encephalopathy"],"prefix":"10.1155","volume":"2021","author":[{"given":"Lin","family":"Wei","sequence":"first","affiliation":[{"name":"Department of Neonatology, Jinan Maternal and Child Health Care Hospital, Shandong, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xia","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Neonatology, Jinan Maternal and Child Health Care Hospital, Shandong, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lijuan","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Jinan Maternal and Child Health Care Hospital, Shandong, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanyan","family":"Song","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Chinese People\u2019s Liberation Army of 960 Hospital, Shandong, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4490-9692","authenticated-orcid":true,"given":"Hongmei","family":"Dong","sequence":"additional","affiliation":[{"name":"Department of Neonatology, Jinan Maternal and Child Health Care Hospital, Shandong, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","reference":[{"key":"1","doi-asserted-by":"crossref","first-page":"86","DOI":"10.4103\/1673-5374.264469","article-title":"Single-nucleotide polymorphism screening and RNA sequencing of key messenger RNAs associated with neonatal hypoxic-ischemia brain damage","volume":"15","author":"L. L. Xiong","year":"2020","journal-title":"Neural Regeneration Research"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.2174\/157339631001140408120336"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.1055\/s-2000-9293"},{"key":"4","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1016\/j.cppeds.2010.12.002","article-title":"Current management of the infant who presents with neonatal encephalopathy","volume":"41","author":"E. V. Wachtel","year":"2011","journal-title":"Current Problems in Pediatric and Adolescent Health Care"},{"key":"5","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMcps050929"},{"key":"6","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2017.10.060"},{"key":"7","doi-asserted-by":"publisher","DOI":"10.1007\/s00431-020-03882-3"},{"key":"8","doi-asserted-by":"publisher","DOI":"10.1016\/j.molcel.2014.08.019"},{"key":"9","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuropharm.2018.11.041"},{"key":"10","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.23219"},{"key":"11","doi-asserted-by":"publisher","DOI":"10.1016\/j.molcel.2015.03.027"},{"key":"12","doi-asserted-by":"publisher","DOI":"10.1016\/j.molcel.2018.06.034"},{"key":"13","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.117.017469"},{"key":"14","doi-asserted-by":"publisher","DOI":"10.1155\/2020\/6798590"},{"key":"15","first-page":"4160","article-title":"Intracerebral hemorrhage alters circular RNA expression profiles in the rat brain","volume":"12","author":"Y. Zhong","year":"2020","journal-title":"American Journal of Translational Research"},{"key":"16","doi-asserted-by":"publisher","DOI":"10.1186\/s40659-020-00295-2"},{"key":"17","doi-asserted-by":"publisher","DOI":"10.1080\/21691401.2020.1725536"},{"key":"18","first-page":"1699","article-title":"Circular RNA expression profiles in neonatal rats following hypoxic-ischemic brain damage","volume":"43","author":"L. Jiang","year":"2019","journal-title":"International Journal of Molecular Medicine"},{"key":"19","doi-asserted-by":"publisher","DOI":"10.1038\/nrg2484"},{"key":"20","doi-asserted-by":"publisher","DOI":"10.3892\/mmr.2020.11091"},{"key":"21","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0010247"},{"key":"22","doi-asserted-by":"publisher","DOI":"10.1261\/rna.043687.113"},{"key":"23","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkx863"},{"key":"24","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.05005"},{"key":"25","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-444-64029-1.00013-8"},{"key":"26","doi-asserted-by":"publisher","DOI":"10.14814\/phy2.14110"},{"key":"27","doi-asserted-by":"publisher","DOI":"10.1007\/s12098-012-0703-2"},{"key":"28","doi-asserted-by":"crossref","first-page":"1285","DOI":"10.4103\/1673-5374.189194","article-title":"Protective mechanisms of microRNA-27a against oxygen-glucose deprivation-induced injuries in hippocampal neurons","volume":"11","author":"Q. Cai","year":"2016","journal-title":"Neural Regeneration Research"},{"key":"29","doi-asserted-by":"publisher","DOI":"10.4238\/gmr.15027371"},{"key":"30","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.1982-13.2014"},{"key":"31","doi-asserted-by":"publisher","DOI":"10.1007\/s10735-013-9555-y"},{"key":"32","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2021.111553"},{"key":"33","doi-asserted-by":"publisher","DOI":"10.1038\/aps.2013.89"},{"key":"34","doi-asserted-by":"publisher","DOI":"10.1093\/tropej\/fmp098"},{"key":"35","doi-asserted-by":"publisher","DOI":"10.1007\/s12026-015-8751-0"},{"key":"36","doi-asserted-by":"publisher","DOI":"10.1016\/S1875-5364(19)30071-8"},{"key":"37","doi-asserted-by":"publisher","DOI":"10.1007\/s12035-015-9318-8"},{"key":"38","doi-asserted-by":"publisher","DOI":"10.1016\/j.pneurobio.2016.06.006"},{"key":"39","article-title":"Interleukin 10 plays an important role in neonatal rats with hypoxic-ischemia associated with B-cell lymphoma 2 and endoplasmic reticulum protein 29","volume":"2021, article 6622713","author":"X. Bai","year":"2021","journal-title":"Analytical Cellular Pathology (Amsterdam)"},{"key":"40","doi-asserted-by":"publisher","DOI":"10.1016\/j.neulet.2014.07.003"},{"key":"41","doi-asserted-by":"publisher","DOI":"10.1186\/s13041-015-0157-3"},{"key":"42","doi-asserted-by":"publisher","DOI":"10.1038\/s41390-020-0978-3"},{"key":"43","doi-asserted-by":"publisher","DOI":"10.1007\/s12975-015-0431-9"},{"key":"44","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1159\/000496467","article-title":"The arginase pathway in neonatal brain hypoxia-ischemia","volume":"40","author":"J. Krystofova","year":"2019","journal-title":"Developmental Neuroscience"},{"key":"45","doi-asserted-by":"publisher","DOI":"10.1007\/s13258-020-01007-6"},{"key":"46","doi-asserted-by":"publisher","DOI":"10.1261\/rna.047126.114"},{"key":"47","doi-asserted-by":"publisher","DOI":"10.1038\/nrneurol.2013.67"},{"key":"48","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddab201"},{"key":"49","doi-asserted-by":"publisher","DOI":"10.1097\/WNR.0000000000001124"},{"key":"50","doi-asserted-by":"publisher","DOI":"10.1177\/1010428317719273"}],"container-title":["Computational and Mathematical Methods in Medicine"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/cmmm\/2021\/6015473.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/cmmm\/2021\/6015473.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/cmmm\/2021\/6015473.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,9,22]],"date-time":"2021-09-22T18:54:20Z","timestamp":1632336860000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.hindawi.com\/journals\/cmmm\/2021\/6015473\/"}},"subtitle":[],"editor":[{"given":"Jun","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2021,9,21]]},"references-count":50,"alternative-id":["6015473","6015473"],"URL":"https:\/\/doi.org\/10.1155\/2021\/6015473","relation":{},"ISSN":["1748-6718","1748-670X"],"issn-type":[{"value":"1748-6718","type":"electronic"},{"value":"1748-670X","type":"print"}],"subject":[],"published":{"date-parts":[[2021,9,21]]}}}