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This underscores the immediate necessity for improved diagnostic, prognostic, and predictive biomarkers for LC. Biopsied lung tissue, blood, and plasma are common sources used for LC diagnosis and monitoring of the disease. A growing number of studies have reported saliva to be a useful biological sample for early and noninvasive detection of oral and systemic diseases. Nevertheless, salivary biomarker discovery remains underresearched. Here, we have compiled the available literature to provide an overview of the current understanding of salivary markers for LC detection and provided perspectives for future clinical significance. Valuable markers with diagnostic and prognostic potentials in LC have been discovered in saliva, including metabolic (catalase activity, triene conjugates, and Schiff bases), inflammatory (interleukin 10, C\u2010X\u2010C motif chemokine ligand 10), proteomic (haptoglobin, zinc\u2010<jats:italic>\u03b1<\/jats:italic>\u20102\u2010glycoprotein, and calprotectin), genomic (epidermal growth factor receptor), and microbial candidates (<jats:italic>Veillonella<\/jats:italic> and <jats:italic>Streptococcus<\/jats:italic>). In combination, with each other and with other established screening methods, these salivary markers could be useful for improving early detection of the disease and ultimately improve the survival odds of LC patients. The existing literature suggests that saliva is a promising biological sample for identification and validation of biomarkers in LC, but how saliva can be utilized most effectively in a clinical setting for LC management is still under investigation.<\/jats:p>","DOI":"10.1155\/2021\/6019791","type":"journal-article","created":{"date-parts":[[2021,10,13]],"date-time":"2021-10-13T17:57:25Z","timestamp":1634147845000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":34,"title":["Salivary Biomarkers in Lung Cancer"],"prefix":"10.1155","volume":"2021","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9083-5188","authenticated-orcid":false,"given":"Hans E.","family":"Skallevold","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4852-8608","authenticated-orcid":false,"given":"Evan M.","family":"Vallenari","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0061-825X","authenticated-orcid":false,"given":"Dipak","family":"Sapkota","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,10,13]]},"reference":[{"key":"e_1_2_10_1_2","doi-asserted-by":"publisher","DOI":"10.1007\/s13277-014-2758-3"},{"key":"e_1_2_10_2_2","unstructured":"Lung Cancer-Non-Small Cell: Statistics 2021 April 2021 https:\/\/www.cancer.net\/cancer-types\/lung-cancer-non-small-cell\/statistics."},{"key":"e_1_2_10_3_2","unstructured":"Lung Cancer-Small Cell: Statistics 2021 April 2021 https:\/\/www.cancer.net\/cancer-types\/lung-cancer-small-cell\/statistics."},{"key":"e_1_2_10_4_2","volume-title":"Cancer Facts & Figures 2021","author":"Society, AC","year":"2021"},{"key":"e_1_2_10_5_2","unstructured":"BasumallikN. 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