{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,5]],"date-time":"2026-09-05T19:17:43Z","timestamp":1788635863664,"version":"build-2803163510"},"reference-count":36,"publisher":"Wiley","license":[{"start":{"date-parts":[[2021,9,30]],"date-time":"2021-09-30T00:00:00Z","timestamp":1632960000000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Disease Markers"],"published-print":{"date-parts":[[2021,9,30]]},"abstract":"<jats:p>Background. Previous studies reported that the level of serum uric acid (SUA) was an important risk factor for acute cerebral infarction (ACI). However, the prognostic value of SUA levels in hospitalized patients with ACI has not been fully elucidated. The aim of this study was to investigate whether the SUA level on admission was associated with subsequent mortality in hospitalized patients with ACI. Methods. The clinical data of ACI patients obtained from December 2017 to December 2019 were retrospectively reviewed. <jats:inline-formula>\n                     <a:math xmlns:a=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M1\">\n                        <a:msup>\n                           <a:mrow>\n                              <a:mi>\u03c7<\/a:mi>\n                           <\/a:mrow>\n                           <a:mrow>\n                              <a:mn>2<\/a:mn>\n                           <\/a:mrow>\n                        <\/a:msup>\n                     <\/a:math>\n                  <\/jats:inline-formula> and Kaplan\u2013Meier methods were used to compare the clinical differences and overall survival between patients with or without hyperuricemia, respectively. Univariate and multivariate analyses were used to identify independent prognoses. Results. In the total population, the in-hospital mortality of the hyperuricemia group was significantly higher than that of the normal uric acid group (<jats:inline-formula>\n                     <c:math xmlns:c=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M2\">\n                        <c:mi>P<\/c:mi>\n                        <c:mo>=<\/c:mo>\n                        <c:mn>0.006<\/c:mn>\n                     <\/c:math>\n                  <\/jats:inline-formula>). In the abnormal renal function group, the in-hospital mortality among the hyperuricemia group was significantly higher than the normal uric acid group (<jats:inline-formula>\n                     <e:math xmlns:e=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M3\">\n                        <e:mi>P<\/e:mi>\n                        <e:mo>=<\/e:mo>\n                        <e:mn>0.002<\/e:mn>\n                     <\/e:math>\n                  <\/jats:inline-formula>). However, there was no statistical difference of in-hospital mortality between the two groups in the normal renal function group (<jats:inline-formula>\n                     <g:math xmlns:g=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M4\">\n                        <g:mi>P<\/g:mi>\n                        <g:mo>=<\/g:mo>\n                        <g:mn>0.321<\/g:mn>\n                     <\/g:math>\n                  <\/jats:inline-formula>). Univariate and multivariate analyses showed that a previous history of diabetes (<jats:inline-formula>\n                     <i:math xmlns:i=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M5\">\n                        <i:mi>P<\/i:mi>\n                        <i:mo>=<\/i:mo>\n                        <i:mn>0.018<\/i:mn>\n                     <\/i:math>\n                  <\/jats:inline-formula>), hyperuricemia (<jats:inline-formula>\n                     <k:math xmlns:k=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M6\">\n                        <k:mi>P<\/k:mi>\n                        <k:mo>=<\/k:mo>\n                        <k:mn>0.001<\/k:mn>\n                     <\/k:math>\n                  <\/jats:inline-formula>), and National Institutes of Health Stroke Scale (NIHSS) score on admission (<jats:inline-formula>\n                     <m:math xmlns:m=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M7\">\n                        <m:mi>P<\/m:mi>\n                        <m:mo>\u2264<\/m:mo>\n                        <m:mn>0.001<\/m:mn>\n                     <\/m:math>\n                  <\/jats:inline-formula>) were independent factors for all samples. The hyperuricemia (<jats:inline-formula>\n                     <o:math xmlns:o=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M8\">\n                        <o:mi>P<\/o:mi>\n                        <o:mo>=<\/o:mo>\n                        <o:mn>0.003<\/o:mn>\n                     <\/o:math>\n                  <\/jats:inline-formula>) on admission were independent factors for patients with abnormal renal function. Conclusions. In ACI patients with abnormal renal function, hyperuricemia may be associated with higher in-hospital mortality than patients with normal uric acid, and hyperuricemia may be an independent associated factor for in-hospital death in the subgroup patients.<\/jats:p>","DOI":"10.1155\/2021\/6103961","type":"journal-article","created":{"date-parts":[[2021,9,30]],"date-time":"2021-09-30T20:25:05Z","timestamp":1633033505000},"page":"1-8","source":"Crossref","is-referenced-by-count":6,"title":["The Prognostic Value of Serum Uric Acid in Hospitalized Patients with Acute Cerebral Infarction"],"prefix":"10.1155","volume":"2021","author":[{"given":"Bangjian","family":"Liu","sequence":"first","affiliation":[{"name":"Department of Neurology, Shanghai Jiao Tong University Affiliated Sixth People\u2019s Hospital, Shanghai, 200233, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yongchao","family":"Pan","sequence":"additional","affiliation":[{"name":"Department of Neurology, Shanghai Jiao Tong University Affiliated Sixth People\u2019s Hospital, Shanghai, 200233, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Cao","sequence":"additional","affiliation":[{"name":"Department of Neurology, Shanghai Jiao Tong University Affiliated Sixth People\u2019s Hospital, Shanghai, 200233, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9111-4577","authenticated-orcid":true,"given":"Jiajun","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Neurology, Shanghai Jiao Tong University Affiliated Sixth People\u2019s Hospital, Shanghai, 200233, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.1159\/000491609"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.4081\/ni.2017.6920"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.1053\/j.ajkd.2017.08.017"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2018.10.129"},{"key":"5","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2005050572"},{"key":"6","doi-asserted-by":"publisher","DOI":"10.26355\/eurrev_202003_20544"},{"key":"7","doi-asserted-by":"publisher","DOI":"10.1093\/qjmed\/95.10.691"},{"key":"8","doi-asserted-by":"publisher","DOI":"10.3390\/nu11081911"},{"key":"9","doi-asserted-by":"publisher","DOI":"10.1080\/00207454.2018.1441150"},{"key":"10","doi-asserted-by":"publisher","DOI":"10.1042\/BSR20171615"},{"key":"11","doi-asserted-by":"publisher","DOI":"10.1007\/s12975-016-0515-1"},{"key":"12","doi-asserted-by":"publisher","DOI":"10.1177\/0300060517752996"},{"key":"13","doi-asserted-by":"publisher","DOI":"10.1016\/j.jstrokecerebrovasdis.2017.12.043"},{"key":"14","doi-asserted-by":"publisher","DOI":"10.2147\/IBPC.S184685"},{"key":"15","doi-asserted-by":"publisher","DOI":"10.1186\/s12872-015-0116-z"},{"key":"16","doi-asserted-by":"publisher","DOI":"10.5812\/numonthly.7(3)2015.27233"},{"key":"17","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-017-05751-w"},{"key":"18","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejim.2015.02.007"},{"key":"19","doi-asserted-by":"publisher","DOI":"10.1002\/brb3.1542"},{"key":"20","doi-asserted-by":"publisher","DOI":"10.1002\/brb3.617"},{"key":"21","doi-asserted-by":"publisher","DOI":"10.1536\/ihj.16-192"},{"key":"22","doi-asserted-by":"publisher","DOI":"10.1080\/01616412.2018.1553347"},{"key":"23","doi-asserted-by":"publisher","DOI":"10.7759\/cureus.6007"},{"key":"24","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.110.596528"},{"key":"25","article-title":"The antioxidant enzyme PON1: a potential prognostic predictor of acute ischemic stroke","volume":"2021","author":"Y. 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