{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,23]],"date-time":"2025-09-23T14:33:54Z","timestamp":1758638034695,"version":"3.40.5"},"reference-count":27,"publisher":"Wiley","license":[{"start":{"date-parts":[[2021,7,29]],"date-time":"2021-07-29T00:00:00Z","timestamp":1627516800000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Oncology"],"published-print":{"date-parts":[[2021,7,29]]},"abstract":"<jats:p>Objective. To investigate the clinical effect of iodine-125 seed implantation combined with chemotherapy in patients with primary liver cancer and the effect on peripheral blood Th1\/Th2 cells. Methods. A total of 136 patients with primary liver cancer from April 2017 to June 2018 were selected as subjects and randomly divided into the control group and observation group with 68 cases in each group. The control group was treated with chemotherapy, and the observation group was treated with iodine-125 seed implantation on the basis of the control group. After 3 months of treatment, the curative effect was investigated. Serum tumor markers, peripheral blood Th1\/Th2 cells, and side effects and recurrence rate were compared between the two groups. Results. The levels of serum tumor markers in both groups at 3 months after treatment were lower than before treatment (<jats:inline-formula>\n                     <a:math xmlns:a=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M1\">\n                        <a:mi>P<\/a:mi>\n                        <a:mo>&lt;<\/a:mo>\n                        <a:mn>0.05<\/a:mn>\n                     <\/a:math>\n                  <\/jats:inline-formula>). Three months after treatment, the levels of tumor markers AFP, AFP-L3, and GP73 in the observation group were 14.61\u2009\u00b1\u20093.49\u2009\u03bcg\/L, 3.29\u2009\u00b1\u20090.41\u2009ng\/mL, and 51.24\u2009\u00b1\u20094.51\u2009\u03bcg\/L, respectively, which were lower than those in the control group, 32.53\u2009\u00b1\u20094.59\u2009\u03bcg\/L, 5.63\u2009\u00b1\u20090.63\u2009ng\/mL, and 71.52\u2009\u00b1\u20096.05\u2009\u03bcg\/L (<jats:inline-formula>\n                     <c:math xmlns:c=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M2\">\n                        <c:mi>P<\/c:mi>\n                        <c:mo>&lt;<\/c:mo>\n                        <c:mn>0.05<\/c:mn>\n                     <\/c:math>\n                  <\/jats:inline-formula>). At 3 months after treatment, the level of including interleukin-2 (IL-2) and tumor necrosis factor-\u03b1 (TNF-\u03b1) in Th1 cells of the observation group was higher than that of the control group (<jats:inline-formula>\n                     <e:math xmlns:e=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M3\">\n                        <e:mi>P<\/e:mi>\n                        <e:mo>&lt;<\/e:mo>\n                        <e:mn>0.05<\/e:mn>\n                     <\/e:math>\n                  <\/jats:inline-formula>), whereas the levels of IL-4, IL-6, and IL-10 in Th2 cells were lower than those in the control group (<jats:inline-formula>\n                     <g:math xmlns:g=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M4\">\n                        <g:mi>P<\/g:mi>\n                        <g:mo>&lt;<\/g:mo>\n                        <g:mn>0.05<\/g:mn>\n                     <\/g:math>\n                  <\/jats:inline-formula>). There was no statistical significance in the incidence of leukopenia, thrombocytopenia, and gastrointestinal reactions between the two groups (<jats:inline-formula>\n                     <i:math xmlns:i=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M5\">\n                        <i:mi>P<\/i:mi>\n                        <i:mo>&gt;<\/i:mo>\n                        <i:mn>0.05<\/i:mn>\n                     <\/i:math>\n                  <\/jats:inline-formula>). The recurrence rate of the observation group at 12, 24, and 36 months after treatment was lower than that of the control group (<jats:inline-formula>\n                     <k:math xmlns:k=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M6\">\n                        <k:mi>P<\/k:mi>\n                        <k:mo>&lt;<\/k:mo>\n                        <k:mn>0.05<\/k:mn>\n                     <\/k:math>\n                  <\/jats:inline-formula>). Conclusion. Iodine-125 seed implantation combined with chemotherapy in patients with primary liver cancer can reduce the level of serum tumor markers, improve the level of peripheral blood Th1\/Th2 cells, and reduce the recurrence rate of patients without increasing the incidence of side effects, which is worthy of promoting the application of iodine-125 seed implantation.<\/jats:p>","DOI":"10.1155\/2021\/6199732","type":"journal-article","created":{"date-parts":[[2021,7,29]],"date-time":"2021-07-29T22:50:15Z","timestamp":1627599015000},"page":"1-6","source":"Crossref","is-referenced-by-count":7,"title":["Clinical Effect of Iodine-125 Seed Implantation in Patients with Primary Liver Cancer and Its Effect on Th1\/Th2 Cells in Peripheral Blood"],"prefix":"10.1155","volume":"2021","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1856-0626","authenticated-orcid":true,"given":"Xiaoyan","family":"Chen","sequence":"first","affiliation":[{"name":"Department of Hepatobiliary Surgery, Renmin Hospital of Wuhan University, Wuhan 430060, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fan","family":"Zhu","sequence":"additional","affiliation":[{"name":"Department of Hepatobiliary Surgery, Ezhou Central Hospital, Ezhou 436099, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bin","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Hepatobiliary Surgery, Renmin Hospital of Wuhan University, Wuhan 430060, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yu","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Hepatobiliary Surgery, Renmin Hospital of Wuhan University, Wuhan 430060, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hao","family":"Xiong","sequence":"additional","affiliation":[{"name":"Department of Hepatobiliary Surgery, Renmin Hospital of Wuhan University, Wuhan 430060, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tao","family":"Fan","sequence":"additional","affiliation":[{"name":"Department of Outpatient, Chengdu Wuhou District Enxi Medical Cosmetology Hospital, Chengdu 610047, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3159-672X","authenticated-orcid":true,"given":"Wenjie","family":"Ke","sequence":"additional","affiliation":[{"name":"Department of Henia and Abdominal Wall Surgery, The Central Hospital of Wuhan, Tongji Medical College, Huazhong Univerity of Science and Technology, Wuhan 430030, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","reference":[{"issue":"17","key":"1","first-page":"1310","article-title":"Preliminary study on radiofrequency ablation of primary hepatocellular carcinoma with radiofrequency implantation","volume":"100","author":"Y. 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Jiahuan","year":"2020","journal-title":"Liver"},{"issue":"2","key":"5","first-page":"268","article-title":"Clinical study of iodine-125 seed implantation brachytherapy combined with chemotherapy in the treatment of advanced non-small cell lung cancer in the elderly","volume":"23","author":"H. Y. L. Hong","year":"2020","journal-title":"Journal of Practical Hepatology"},{"key":"6","doi-asserted-by":"publisher","DOI":"10.1016\/j.suc.2020.02.013"},{"issue":"19","key":"7","first-page":"2487","article-title":"Clinical study of iodine-125 seed implantation brachytherapy combined with chemotherapy in the treatment of advanced non-small cell lung cancer in the elderly","volume":"42","author":"W. B. L. Chunrong","year":"2020","journal-title":"Guangxi Medical Journal"},{"issue":"4","key":"8","first-page":"272","article-title":"Expression of BUB1B in primary hepatocellular carcinoma and its effect on proliferation and invasion of hepatocellular carcinoma cells","volume":"50","author":"Z. H. M. Yan","year":"2019","journal-title":"Journal of New Medicine"},{"key":"9","doi-asserted-by":"publisher","DOI":"10.1007\/s00268-020-05565-4"},{"issue":"8","key":"10","first-page":"1419","article-title":"Guidelines for diagnosis and treatment of primary liver cancer (2017 edition)","volume":"33","author":"National Health and Family Planning Commission","year":"2017","journal-title":"Journal of Clinical Hepatology"},{"issue":"23","key":"11","first-page":"1770","article-title":"Effects of addy injection combined with hepatic arterial chemoembolization on vascular growth factors and cellular immune function in patients with primary liver cancer","volume":"25","author":"L. G. Z. 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Wenjuan","year":"2019","journal-title":"World Journal of Traditional Chinese Medicine"},{"issue":"1","key":"15","first-page":"89","article-title":"Effect of TIPS combined with 125I seed implantation in the treatment of main portal emboli and complications of liver cancer","volume":"29","author":"Z. T. W. Yue","year":"2020","journal-title":"Journal of Interventional Radiology"},{"issue":"5","key":"16","first-page":"428","article-title":"Efficacy of ultrasound-guided microwave ablation combined with TACE in the treatment of advanced primary liver cancer and its effect on immune function","volume":"36","author":"Y. T. Z. Lixin","year":"2020","journal-title":"Chinese Journal of Ultrasound in Medicine"},{"key":"17","doi-asserted-by":"publisher","DOI":"10.1186\/s12885-019-5461-3"},{"key":"18","doi-asserted-by":"publisher","DOI":"10.1097\/md.0000000000020962"},{"key":"19","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2019.11.006"},{"key":"20","doi-asserted-by":"publisher","DOI":"10.3760\/cma.j.issn.1007-3418.2018.04.013"},{"key":"21","doi-asserted-by":"publisher","DOI":"10.1016\/j.hpb.2018.03.015"},{"key":"22","doi-asserted-by":"publisher","DOI":"10.3892\/ol.2016.5033"},{"key":"23","doi-asserted-by":"publisher","DOI":"10.1111\/1556-4029.13296"},{"key":"24","doi-asserted-by":"publisher","DOI":"10.1186\/1756-9966-31-61"},{"issue":"4","key":"25","first-page":"435","article-title":"Effect of radioactive iodine seed implantation on immune function and therapeutic effect in patients with primary liver cancer","volume":"17","author":"Z. Y. W. Xiao","year":"2019","journal-title":"Oncology Progress"},{"issue":"18","key":"26","first-page":"2230","article-title":"Effect of heatongxiao granules combined with hepatic arterial chemoembolization in the treatment of primary hepatocellular carcinoma and its effect on interleukin-12 interleukin-10 interferon","volume":"22","author":"L. M. L. Ping","year":"2019","journal-title":"Chinese General Practice"},{"issue":"14","key":"27","first-page":"1525","article-title":"Feasibility evaluation of electromagneticpositioning and navigation 125I seed implantation in the treatment of advanced primary liver cancer","volume":"18","author":"C. L. L. Wang","year":"2019","journal-title":"Journal of Clinical and Experimental Medicine"}],"container-title":["Journal of Oncology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/jo\/2021\/6199732.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/jo\/2021\/6199732.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/jo\/2021\/6199732.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,7,29]],"date-time":"2021-07-29T22:50:32Z","timestamp":1627599032000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.hindawi.com\/journals\/jo\/2021\/6199732\/"}},"subtitle":[],"editor":[{"given":"Muhammad Wasim","family":"Khan","sequence":"additional","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2021,7,29]]},"references-count":27,"alternative-id":["6199732","6199732"],"URL":"https:\/\/doi.org\/10.1155\/2021\/6199732","relation":{},"ISSN":["1687-8469","1687-8450"],"issn-type":[{"type":"electronic","value":"1687-8469"},{"type":"print","value":"1687-8450"}],"subject":[],"published":{"date-parts":[[2021,7,29]]}}}