{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T15:46:52Z","timestamp":1788968812364,"version":"build-2803163510"},"reference-count":59,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2021,12,13]],"date-time":"2021-12-13T00:00:00Z","timestamp":1639353600000},"content-version":"vor","delay-in-days":346,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["U20A2055"],"award-info":[{"award-number":["U20A2055"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Oxidative Medicine and Cellular Longevity"],"published-print":{"date-parts":[[2021,1]]},"abstract":"<jats:p>Antioxidant polyphenols from plants are potential dietary supplementation to alleviate early weaning\u2010induced intestinal disorders in piglets. Recent evidences showed polyphenol quercetin could reshape gut microbiota when it functioned as anti\u2010inflammation or antioxidation agents in rodent models. However, the effect of dietary quercetin supplementation on intestinal disorders and gut microbiota of weanling piglets, along with the role of gut microbiota in this effect, both remain unclear. Here, we determined the quercetin\u2019s effect on attenuating diarrhea, intestinal damage, and redox imbalance, as well as the role of gut microbiota by transferring the quercetin\u2010treated fecal microbiota to the recipient piglets. The results showed that dietary quercetin supplementation decreased piglets\u2019 fecal scores improved intestinal damage by increasing tight junction protein occludin, villus height, and villus height\/crypt depth ratio but decreased crypt depth and intestinal epithelial apoptosis (TUNEL staining). Quercetin also increased antioxidant capacity indices, including total antioxidant capacity, catalase, and glutathione\/oxidized glutathione disulfide but decreased oxidative metabolite malondialdehyde in the jejunum tissue. Fecal microbiota transplantation (FMT) from quercetin\u2010treated piglets had comparable effects on improving intestinal damage and antioxidative capacity than dietary quercetin supplementation. Further analysis of gut microbiota using 16S rDNA sequencing showed that dietary quercetin supplementation or FMT shifted the structure and increased the diversity of gut microbiota. Especially, anaerobic trait and carbohydrate metabolism functions of gut microbiota were enriched after dietary quercetin supplementation and FMT, which may owe to the increased antioxidative capacity of intestine. Quercetin increased the relative abundances of Fibrobacteres, <jats:italic>Akkermansia muciniphila<\/jats:italic>, <jats:italic>Clostridium butyricum<\/jats:italic>, <jats:italic>Clostridium celatum<\/jats:italic>, and <jats:italic>Prevotella copri<\/jats:italic> but decreased the relative abundances of Proteobacteria, <jats:italic>Lactobacillus coleohominis<\/jats:italic>, and <jats:italic>Ruminococcus bromii<\/jats:italic>. Besides, quercetin\u2010shifted bacteria and carbohydrate metabolites short chain fatty acids were significantly related to the indices of antioxidant capacity and intestinal integrity. Overall, dietary quercetin supplementation attenuated diarrhea and intestinal damage by enhancing the antioxidant capacity and regulating gut microbial structure and metabolism in piglets.<\/jats:p>","DOI":"10.1155\/2021\/6221012","type":"journal-article","created":{"date-parts":[[2021,12,14]],"date-time":"2021-12-14T02:50:09Z","timestamp":1639450209000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":63,"title":["[Retracted] Dietary Quercetin Supplementation Attenuates Diarrhea and Intestinal Damage by Regulating Gut Microbiota in Weanling Piglets"],"prefix":"10.1155","volume":"2021","author":[{"given":"Baoyang","family":"Xu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenxia","family":"Qin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yunzheng","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenbo","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuwen","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juncheng","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianan","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6806-6899","authenticated-orcid":false,"given":"Libao","family":"Ma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,12,13]]},"reference":[{"key":"e_1_2_10_1_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.tim.2017.05.004"},{"key":"e_1_2_10_2_2","doi-asserted-by":"publisher","DOI":"10.1186\/2049-1891-4-19"},{"key":"e_1_2_10_3_2","doi-asserted-by":"publisher","DOI":"10.1017\/s0029665107005484"},{"key":"e_1_2_10_4_2","doi-asserted-by":"publisher","DOI":"10.2527\/jas.2013-6986"},{"key":"e_1_2_10_5_2","doi-asserted-by":"publisher","DOI":"10.2527\/jas.2012-4444"},{"key":"e_1_2_10_6_2","doi-asserted-by":"publisher","DOI":"10.3402\/mehd.v25.25862"},{"key":"e_1_2_10_7_2","doi-asserted-by":"publisher","DOI":"10.1155\/2016\/7432797"},{"key":"e_1_2_10_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.fct.2007.05.015"},{"key":"e_1_2_10_9_2","doi-asserted-by":"publisher","DOI":"10.3390\/antiox5040041"},{"key":"e_1_2_10_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.fct.2018.10.042"},{"key":"e_1_2_10_11_2","doi-asserted-by":"publisher","DOI":"10.3390\/nu13010206"},{"key":"e_1_2_10_12_2","doi-asserted-by":"publisher","DOI":"10.1093\/molehr\/gat031"},{"key":"e_1_2_10_13_2","doi-asserted-by":"publisher","DOI":"10.2527\/jas1988.66112893x"},{"key":"e_1_2_10_14_2","doi-asserted-by":"publisher","DOI":"10.1039\/c7fo01383c"},{"key":"e_1_2_10_15_2","doi-asserted-by":"publisher","DOI":"10.1155\/2018\/8343052"},{"key":"e_1_2_10_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.anifeedsci.2011.06.006"},{"key":"e_1_2_10_17_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrgastro.2016.98"},{"key":"e_1_2_10_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.phrs.2021.105767"},{"key":"e_1_2_10_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.phrs.2019.104489"},{"key":"e_1_2_10_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/s0891-5849(00)00195-7"},{"key":"e_1_2_10_21_2","doi-asserted-by":"publisher","DOI":"10.3390\/antiox8080312"},{"key":"e_1_2_10_22_2","doi-asserted-by":"publisher","DOI":"10.1186\/s40104-021-00578-y"},{"key":"e_1_2_10_23_2","doi-asserted-by":"publisher","DOI":"10.2527\/2005.833634x"},{"key":"e_1_2_10_24_2","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.119.3.493"},{"key":"e_1_2_10_25_2","doi-asserted-by":"publisher","DOI":"10.1038\/nmeth.2089"},{"key":"e_1_2_10_26_2","doi-asserted-by":"publisher","DOI":"10.1039\/d0fo03080e"},{"key":"e_1_2_10_27_2","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btu170"},{"key":"e_1_2_10_28_2","doi-asserted-by":"publisher","DOI":"10.1089\/cmb.2017.0096"},{"key":"e_1_2_10_29_2","doi-asserted-by":"publisher","DOI":"10.1038\/nmeth.2604"},{"key":"e_1_2_10_30_2","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btr381"},{"key":"e_1_2_10_31_2","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gks1219"},{"key":"e_1_2_10_32_2","doi-asserted-by":"publisher","DOI":"10.1128\/aem.03006-05"},{"key":"e_1_2_10_33_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41587-020-0548-6"},{"key":"e_1_2_10_34_2","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2019.03125"},{"key":"e_1_2_10_35_2","doi-asserted-by":"crossref","unstructured":"WardT. 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