{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,23]],"date-time":"2026-01-23T20:03:43Z","timestamp":1769198623688,"version":"3.49.0"},"reference-count":18,"publisher":"Wiley","license":[{"start":{"date-parts":[[2021,12,23]],"date-time":"2021-12-23T00:00:00Z","timestamp":1640217600000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Healthcare Engineering"],"published-print":{"date-parts":[[2021,12,23]]},"abstract":"<jats:p>The objective of this study was to analyze the application of proportional hazard mathematical model (PHMM) in Hepatitis B Virus (HBV) infection analysis of interventional liver cancer patients treated with entecavir, so as to provide data support for clinical diagnosis and treatment. Based on the survival analysis, the treatment factor x was undertaken as an independent variable to perform linear regression. The regression model took the hazard rate function as the dependent variable to establish an exponential regression equation to construct a PHMM. 136 patients with primary liver cancer receiving interventional chemoembolization combined with the drug (entecavir) were selected as the experimental group, who were in the computer gene expression omnibus (GEO). 87 patients with primary liver cancer who underwent interventional chemoembolization therapy without antiviral treatment were taken as the control group. The PHMM was adopted for comprehensive analysis. In addition, the factors affecting the virological response to antiviral therapy were analyzed using the multiple logistic regression. The results revealed that HBV deoxyribonucleic acid (DNA) negative conversion rate, Hepatitis B e-Antigen (HBeAg) negative conversion rate, and HBeAg serological conversion rate in the experimental group were much higher than those in the control group (<jats:inline-formula>\n                     <a:math xmlns:a=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M1\">\n                        <a:mi>P<\/a:mi>\n                        <a:mo>&lt;<\/a:mo>\n                        <a:mn>0.05<\/a:mn>\n                     <\/a:math>\n                  <\/jats:inline-formula>). HBV DNA level and proportion of HBsAg &lt;100\u2009IU\/mL in the experimental group were much lower than those in the control group (<jats:inline-formula>\n                     <c:math xmlns:c=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M2\">\n                        <c:mi>P<\/c:mi>\n                        <c:mo>&lt;<\/c:mo>\n                        <c:mn>0.05<\/c:mn>\n                     <\/c:math>\n                  <\/jats:inline-formula>). The virological breakthrough rate and incidence of adverse events at week 24 in the experimental group were greatly lower than those in the control group (<jats:inline-formula>\n                     <e:math xmlns:e=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M3\">\n                        <e:mi>P<\/e:mi>\n                        <e:mo>&lt;<\/e:mo>\n                        <e:mn>0.05<\/e:mn>\n                     <\/e:math>\n                  <\/jats:inline-formula>). The adverse virological response of patient was positively correlated with HBV DNA load and HBeAg status and negatively correlated with alanine aminotransferase (ALT) level (<jats:inline-formula>\n                     <g:math xmlns:g=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M4\">\n                        <g:mi>P<\/g:mi>\n                        <g:mo>&lt;<\/g:mo>\n                        <g:mn>0.05<\/g:mn>\n                     <\/g:math>\n                  <\/jats:inline-formula>). Therefore, entecavir can significantly inhibit HBV DNA replication in patients with liver cancer, showing high antiviral effect. High baseline HBV DNA load, positive HBeAg, and low baseline alanine aminotransferase levels were independent risk factors for adverse virology response to entecavir antiviral therapy, which provided a reference for the selection of antiviral drugs for HBV infection.<\/jats:p>","DOI":"10.1155\/2021\/6225403","type":"journal-article","created":{"date-parts":[[2021,12,23]],"date-time":"2021-12-23T18:35:19Z","timestamp":1640284519000},"page":"1-8","source":"Crossref","is-referenced-by-count":3,"title":["Big Data Information under Proportional Hazard Mathematical Model in Analysis of Hepatitis B Virus Infection Data of Patients with Interventional Liver Cancer through Antiviral Therapy of Entecavir"],"prefix":"10.1155","volume":"2021","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2829-2442","authenticated-orcid":true,"given":"Yichi","family":"Zhang","sequence":"first","affiliation":[{"name":"Department of Transplantation, Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, 1665 Kongjiang Road, Yangpu District, Shanghai 200092, China"},{"name":"Department of General Surgery, Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, 1665 Kongjiang Road, Yangpu District, Shanghai 200092, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0246-6862","authenticated-orcid":true,"given":"Shuai","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Transplantation, Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, 1665 Kongjiang Road, Yangpu District, Shanghai 200092, China"},{"name":"Department of General Surgery, Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, 1665 Kongjiang Road, Yangpu District, Shanghai 200092, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7915-4800","authenticated-orcid":true,"given":"Han","family":"Ding","sequence":"additional","affiliation":[{"name":"Department of Transplantation, Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, 1665 Kongjiang Road, Yangpu District, Shanghai 200092, China"},{"name":"Department of General Surgery, Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, 1665 Kongjiang Road, Yangpu District, Shanghai 200092, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4723-4117","authenticated-orcid":true,"given":"Xiaoling","family":"Song","sequence":"additional","affiliation":[{"name":"Department of Transplantation, Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, 1665 Kongjiang Road, Yangpu District, Shanghai 200092, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8958-2128","authenticated-orcid":true,"given":"Huijie","family":"Miao","sequence":"additional","affiliation":[{"name":"Department of Transplantation, Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, 1665 Kongjiang Road, Yangpu District, Shanghai 200092, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0228-0793","authenticated-orcid":true,"given":"Xuya","family":"Cui","sequence":"additional","affiliation":[{"name":"Department of Transplantation, Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, 1665 Kongjiang Road, Yangpu District, Shanghai 200092, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1959-9490","authenticated-orcid":true,"given":"Jian","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Transplantation, Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, 1665 Kongjiang Road, Yangpu District, Shanghai 200092, China"},{"name":"Department of General Surgery, Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, 1665 Kongjiang Road, Yangpu District, Shanghai 200092, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0688-6637","authenticated-orcid":true,"given":"Bing","family":"Han","sequence":"additional","affiliation":[{"name":"Department of Transplantation, Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, 1665 Kongjiang Road, Yangpu District, Shanghai 200092, China"},{"name":"Department of General Surgery, Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, 1665 Kongjiang Road, Yangpu District, Shanghai 200092, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/jiz477"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.3389\/fnins.2021.714318"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.1080\/17843286.2018.1517076"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.1097\/cmr.0000000000000434"},{"key":"5","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejca.2019.05.032"},{"key":"6","doi-asserted-by":"publisher","DOI":"10.14309\/00000434-201810001-00999"},{"key":"7","doi-asserted-by":"publisher","DOI":"10.1093\/ajcp\/aqy090.094"},{"key":"8","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejca.2019.11.010"},{"key":"9","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/key157"},{"key":"10","doi-asserted-by":"publisher","DOI":"10.17998\/jlc.19.2.128"},{"key":"11","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcma.2017.07.009"},{"key":"12","doi-asserted-by":"publisher","DOI":"10.1111\/jgh.14637"},{"issue":"2","key":"13","doi-asserted-by":"crossref","first-page":"271","DOI":"10.14309\/ajg.0000000000000428","article-title":"Tenofovir versus entecavir for hepatocellular carcinoma prevention in an international Consortium of chronic hepatitis B","volume":"115","author":"Y. C. Hsu","year":"2020","journal-title":"American Journal of Gastroenterology"},{"key":"14","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2019.03.028"},{"key":"15","doi-asserted-by":"publisher","DOI":"10.1016\/S2468-1253(18)30002-5"},{"key":"16","doi-asserted-by":"publisher","DOI":"10.1200\/edbk_200939"},{"issue":"11","key":"17","first-page":"13","article-title":"Effect of kushenin combined with entecavir therapy on hepatic fibrosis and immune response in patients with chronic hepatitis B","volume":"24","author":"R. Zhu","year":"2018","journal-title":"Journal of Hainan Medical University"},{"key":"18","doi-asserted-by":"publisher","DOI":"10.1016\/s0140-6736(18)32111-1"}],"container-title":["Journal of Healthcare Engineering"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/jhe\/2021\/6225403.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/jhe\/2021\/6225403.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/jhe\/2021\/6225403.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,12,23]],"date-time":"2021-12-23T18:35:26Z","timestamp":1640284526000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.hindawi.com\/journals\/jhe\/2021\/6225403\/"}},"subtitle":[],"editor":[{"given":"Enas","family":"Abdulhay","sequence":"additional","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2021,12,23]]},"references-count":18,"alternative-id":["6225403","6225403"],"URL":"https:\/\/doi.org\/10.1155\/2021\/6225403","relation":{},"ISSN":["2040-2309","2040-2295"],"issn-type":[{"value":"2040-2309","type":"electronic"},{"value":"2040-2295","type":"print"}],"subject":[],"published":{"date-parts":[[2021,12,23]]}}}