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Loss of neurons in damaged area is hardly rescued by relative molecular therapies. Based on its disease characteristics, we transplanted human embryonic stem cell\u2010 (hESC\u2010) derived cerebral organoids in the brain lesions of controlled cortical impact\u2010 (CCI\u2010) modeled severe combined immunodeficient (SCID) mice. Grafted organoids survived and differentiated in CCI\u2010induced lesion pools in mouse cortical tissue. Implanted cerebral organoids differentiated into various types of neuronal cells, extended long projections, and showed spontaneous action, as indicated by electromyographic activity in the grafts. Induced vascularization and reduced glial scar were also found after organoid implantation, suggesting grafting could improve local situation and promote neural repair. More importantly, the CCI mice\u2019s spatial learning and memory improved after organoid grafting. 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