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In the present study, we aimed to investigate whether the radiomic features of baseline 18F-FDG PET can predict the prognosis of Hodgkin lymphoma (HL). Methods. A total 65 HL patients (training cohort: n\u2009=\u200949; validation cohort: n\u2009=\u200916) were retrospectively enrolled in the present study. A total of 47 radiomic features were extracted from pretreatment PET images. The least absolute shrinkage and selection operator (LASSO) regression was used to select the most useful prognostic features in the training cohort. The distance between the two lesions that were the furthest apart (Dmax) was recorded. The receiver operating characteristic (ROC) curve, Kaplan\u2013Meier method, and Cox proportional hazards model were used to assess the prognostic factors. Results. Long-zone high gray-level emphasis extracted from a gray-level zone-length matrix (LZHGEGLZLM) (HR\u2009=\u20099.007;\n                    <jats:inline-formula>\n                      <a:math xmlns:a=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M1\">\n                        <a:mi>p<\/a:mi>\n                        <a:mo>=<\/a:mo>\n                        <a:mn>0.044<\/a:mn>\n                      <\/a:math>\n                    <\/jats:inline-formula>\n                    ) and Dmax (HR\u2009=\u20093.641;\n                    <jats:inline-formula>\n                      <c:math xmlns:c=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M2\">\n                        <c:mi>p<\/c:mi>\n                        <c:mo>=<\/c:mo>\n                        <c:mn>0.048<\/c:mn>\n                      <\/c:math>\n                    <\/jats:inline-formula>\n                    ) were independently correlated with 2-year progression-free survival (PFS). A prognostic stratification model was established based on both risk predictors, which could distinguish three risk categories for PFS (\n                    <jats:inline-formula>\n                      <e:math xmlns:e=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M3\">\n                        <e:mi>p<\/e:mi>\n                        <e:mo>=<\/e:mo>\n                        <e:mn>0.0002<\/e:mn>\n                      <\/e:math>\n                    <\/jats:inline-formula>\n                    ). The 2-year PFS was 100.0%, 64.7%, and 33.3%, respectively. Conclusions. LZHGEGLZLM and Dmax were independent prognostic factors for survival outcomes. Besides, we proposed a prognostic stratification model that could further improve the risk stratification of HL patients.\n                  <\/jats:p>","DOI":"10.1155\/2021\/6347404","type":"journal-article","created":{"date-parts":[[2021,11,22]],"date-time":"2021-11-22T19:20:21Z","timestamp":1637608821000},"page":"1-8","source":"Crossref","is-referenced-by-count":30,"title":["Radiomic Features of 18F-FDG PET in Hodgkin Lymphoma Are Predictive of Outcomes"],"prefix":"10.1155","volume":"2021","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9797-3121","authenticated-orcid":true,"given":"Yeye","family":"Zhou","sequence":"first","affiliation":[{"name":"Department of Nuclear Medicine, The First Affiliated Hospital of Soochow University, Suzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuchun","family":"Zhu","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine, First People\u2019s Hospital of Kunshan, Kunshan, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhiqiang","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine, The First Affiliated Hospital of Soochow University, Suzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jihui","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine, The First Affiliated Hospital of Soochow University, Suzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3199-391X","authenticated-orcid":true,"given":"Shibiao","family":"Sang","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine, The First Affiliated Hospital of Soochow University, Suzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1450-7721","authenticated-orcid":true,"given":"Shengming","family":"Deng","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine, The First Affiliated Hospital of Soochow University, Suzhou, China"},{"name":"Nuclear Medicine Laboratory of Mianyang Central Hospital, Mianyang 621099, China"},{"name":"State Key Laboratory of Radiation Medicine and Protection, Soochow University, Suzhou,215123, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","reference":[{"issue":"16","key":"1","doi-asserted-by":"crossref","first-page":"1786","DOI":"10.1200\/JCO.2016.68.6394","article-title":"Early positron emission tomography response\u2013adapted treatment in stage I and II Hodgkin lymphoma: final results of the randomized EORTC\/LYSA\/FIL H10 trial","volume":"35","author":"M. 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