{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,31]],"date-time":"2025-12-31T08:08:25Z","timestamp":1767168505491,"version":"build-2238731810"},"reference-count":26,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2021,6,29]],"date-time":"2021-06-29T00:00:00Z","timestamp":1624924800000},"content-version":"vor","delay-in-days":179,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Scientific Research Youth Project of Jinshan District Health Commission of Shanghai city","award":["JSKJ-KTQN-2018-04"],"award-info":[{"award-number":["JSKJ-KTQN-2018-04"]}]},{"name":"Scientific Research Youth Project of Jinshan District Health Commission of Shanghai city","award":["2018-JSYYKT-01"],"award-info":[{"award-number":["2018-JSYYKT-01"]}]},{"name":"Scientific Research Youth Project of Jinshan District Health Commission of Shanghai city","award":["20204Y0172"],"award-info":[{"award-number":["20204Y0172"]}]},{"name":"Hospital-level project of Jinshan Hospital Affiliated to Fudan University","award":["JSKJ-KTQN-2018-04"],"award-info":[{"award-number":["JSKJ-KTQN-2018-04"]}]},{"name":"Hospital-level project of Jinshan Hospital Affiliated to Fudan University","award":["2018-JSYYKT-01"],"award-info":[{"award-number":["2018-JSYYKT-01"]}]},{"name":"Hospital-level project of Jinshan Hospital Affiliated to Fudan University","award":["20204Y0172"],"award-info":[{"award-number":["20204Y0172"]}]},{"name":"Scientific Research Youth Project of Shanghai Municipal Health Commission","award":["JSKJ-KTQN-2018-04"],"award-info":[{"award-number":["JSKJ-KTQN-2018-04"]}]},{"name":"Scientific Research Youth Project of Shanghai Municipal Health Commission","award":["2018-JSYYKT-01"],"award-info":[{"award-number":["2018-JSYYKT-01"]}]},{"name":"Scientific Research Youth Project of Shanghai Municipal Health Commission","award":["20204Y0172"],"award-info":[{"award-number":["20204Y0172"]}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["BioMed Research International"],"published-print":{"date-parts":[[2021,1]]},"abstract":"<jats:p>\n                    <jats:italic>Introduction<\/jats:italic>\n                    . This study was aimed to investigate the effects of N\u2010acetylcysteine (NAC) on chronic obstructive pulmonary disease (COPD) and the change of Th17\/Treg cytokine imbalance.\n                    <jats:italic>Material and Methods<\/jats:italic>\n                    . A total of 121 patients with stable COPD at the stage of C or D were consecutively enrolled and randomly divided into 2 groups. Patients in the treatment group received NAC granules (0.2\u2009g \u00d7 10\u2009bags, 0.4\u2009g each time, 3 times\/d) for half a year. The control group was treated with the same amount of placebo therapy. The peripheral blood of the patient was collected and the cytokine, T lymphocyte subsets were detected.\n                    <jats:italic>Results<\/jats:italic>\n                    . We found the oral administration of NAC could regulate Th17\/Treg balance to resist inflammation in COPD patients. Serum testing showed that the proportion of Treg in CD4+ T cells has increased and the Th17\/Treg ratio has decreased during the NAC treatment. In vitro studies, we found that NAC regulated Th17\/Treg balance through Hypoxia Inducible Factor\u20101\n                    <jats:italic>\u03b1<\/jats:italic>\n                    pathway.\n                    <jats:italic>Conclusions<\/jats:italic>\n                    . Our result could provide new diagnosis and treatment for elderly patients with COPD from the perspective of immunity ideas.\n                  <\/jats:p>","DOI":"10.1155\/2021\/6372128","type":"journal-article","created":{"date-parts":[[2021,6,29]],"date-time":"2021-06-29T17:05:09Z","timestamp":1624986309000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["[Retracted] N\u2010Acetylcysteine Improves Inflammatory Response in COPD Patients by Regulating Th17\/Treg Balance through Hypoxia Inducible Factor\u20101\u03b1 Pathway"],"prefix":"10.1155","volume":"2021","author":[{"given":"Xiaopeng","family":"Liu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhixiong","family":"Hu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6727-7413","authenticated-orcid":false,"given":"Haiying","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2021,6,29]]},"reference":[{"key":"e_1_2_9_1_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccm.2020.06.007"},{"key":"e_1_2_9_2_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00281-020-00784-2"},{"key":"e_1_2_9_3_2","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201902-0374UP"},{"key":"e_1_2_9_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.pharmthera.2019.02.013"},{"key":"e_1_2_9_5_2","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2018.02530"},{"key":"e_1_2_9_6_2","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2018.00066"},{"key":"e_1_2_9_7_2","doi-asserted-by":"publisher","DOI":"10.1586\/17476348.2016.1121105"},{"key":"e_1_2_9_8_2","doi-asserted-by":"publisher","DOI":"10.1093\/qjmed\/hcy166"},{"key":"e_1_2_9_9_2","doi-asserted-by":"publisher","DOI":"10.7860\/JCDR\/2016\/23668.8980"},{"key":"e_1_2_9_10_2","doi-asserted-by":"publisher","DOI":"10.1186\/s40248-016-0039-2"},{"key":"e_1_2_9_11_2","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000013087"},{"key":"e_1_2_9_12_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajplung.00304.2016"},{"key":"e_1_2_9_13_2","doi-asserted-by":"publisher","DOI":"10.1111\/imr.12029"},{"key":"e_1_2_9_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.coi.2013.08.002"},{"key":"e_1_2_9_15_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10517-014-2438-8"},{"key":"e_1_2_9_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.autrev.2013.12.004"},{"key":"e_1_2_9_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbadis.2020.165921"},{"key":"e_1_2_9_18_2","doi-asserted-by":"publisher","DOI":"10.1002\/jso.26276"},{"key":"e_1_2_9_19_2","doi-asserted-by":"publisher","DOI":"10.1093\/ejcts\/ezz253"},{"key":"e_1_2_9_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.rmed.2011.05.017"},{"key":"e_1_2_9_21_2","first-page":"5324","article-title":"Imbalances of Th17 and Treg cells and their respective cytokines in COPD patients by disease stage","volume":"7","author":"Li X.","year":"2014","journal-title":"International Journal of Clinical and Experimental Medicine"},{"key":"e_1_2_9_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajem.2016.03.032"},{"key":"e_1_2_9_23_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2013.11.007"},{"key":"e_1_2_9_24_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2011.07.033"},{"key":"e_1_2_9_25_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0112350"},{"key":"e_1_2_9_26_2","doi-asserted-by":"publisher","DOI":"10.2147\/copd.s79710"}],"updated-by":[{"DOI":"10.1155\/2024\/9753627","type":"retraction","label":"Retraction","source":"retraction-watch","updated":{"date-parts":[[2024,3,20]],"date-time":"2024-03-20T00:00:00Z","timestamp":1710892800000},"record-id":"67055"},{"DOI":"10.1155\/2024\/9753627","type":"retraction","label":"Retraction","source":"publisher","updated":{"date-parts":[[2024,3,4]],"date-time":"2024-03-04T00:00:00Z","timestamp":1709510400000}}],"container-title":["BioMed Research International"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/bmri\/2021\/6372128.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/bmri\/2021\/6372128.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1155\/2021\/6372128","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,12,31]],"date-time":"2024-12-31T02:09:26Z","timestamp":1735610966000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1155\/2021\/6372128"}},"subtitle":[],"editor":[{"given":"Tao","family":"Huang","sequence":"additional","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2021,1]]},"references-count":26,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2021,1]]}},"alternative-id":["10.1155\/2021\/6372128"],"URL":"https:\/\/doi.org\/10.1155\/2021\/6372128","archive":["Portico"],"relation":{},"ISSN":["2314-6133","2314-6141"],"issn-type":[{"value":"2314-6133","type":"print"},{"value":"2314-6141","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,1]]},"assertion":[{"value":"2021-04-24","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-06-17","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-06-29","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"6372128"}}