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To investigate the impact of different\u2010intensity exercise on lipid metabolism, oxidative stress, hepatocyte injury, and apoptosis and the related protein expression of endoplasmic reticulum stress on nonalcoholic fatty liver disease rats. <jats:italic>Method<\/jats:italic>. 50 male Sprague\u2013Dawley rats, 2 months old, were randomly divided into the normal control (CON) group, high\u2010fat diet (HFD) group, low\u2010intensity exercise (LIE) group, moderate\u2010intensity exercise (MIE) group, and incremental\u2010intensity exercise (IIE) group. Blood lipids were tested by the automatic biochemical analyzer. The changes in liver tissues were observed by hematoxylin\u2010eosin staining (HE). The protein expression of Bax and Bcl\u20102 was detected by the immunohistochemical method. The apoptosis of hepatocytes was detected by the TUNEL method. The protein expression of GRP78, Caspase\u20103, IRE1, p\u2010IRE1, JNK1, CHOP, PERK, eIF2<jats:italic>\u03b1<\/jats:italic>, and ATF4 was detected by Western blotting. <jats:italic>Results<\/jats:italic>. Our study showed that compared with the HFD group, TG, TC, FFA, and LDL\u2010c were reduced in all exercise groups. The different exercise intensities could reduce the protein expression of ATF4, Bax, and hepatocyte apoptosis. Meanwhile, the antioxidant function and Bcl\u20102 were increased. However, the moderate\u2010intensity exercise demonstrated more effect on improving the antioxidant capacity and inhibiting hepatocyte apoptosis. Compared with the HFD group, Caspase\u20103 and JNK were significantly decreased in all exercise groups (<jats:italic>P<\/jats:italic> &lt; 0.01) and CHOP was decreased in the LIE and MIE groups (<jats:italic>P<\/jats:italic> &lt; 0.05). IRE1, eIF2<jats:italic>\u03b1<\/jats:italic>, the ratio of p\u2010IRE1\/IRE1 (<jats:italic>P<\/jats:italic> &lt; 0.01), and ATF4 were decreased (<jats:italic>P<\/jats:italic> &lt; 0.05) in the MIE group. Compared with the IIE group, p\u2010IRE1 was decreased (<jats:italic>P<\/jats:italic> &lt; 0.05) in the MIE group. GRP78 had no significant difference among the exercise groups. <jats:italic>Conclusion<\/jats:italic>. Exercise at different intensities improved blood lipid and hepatic injury in NAFLD rats. However, the body weight of the rats in each exercise group was not significantly different. Moderate\u2010intensity exercise demonstrated more effect on improving the antioxidant ability and inhibiting hepatocyte apoptosis. The possible mechanism depends on the regulation of endoplasmic reticulum stress signaling pathways IRE1\/JNK and eIF2<jats:italic>\u03b1<\/jats:italic>\/CHOP.<\/jats:p>","DOI":"10.1155\/2021\/6378568","type":"journal-article","created":{"date-parts":[[2021,3,16]],"date-time":"2021-03-16T19:36:40Z","timestamp":1615923400000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["Effect of Different Exercise Intensities on Hepatocyte Apoptosis in HFD\u2010Induced NAFLD in Rats: The Possible Role of Endoplasmic Reticulum Stress through the Regulation of the IRE1\/JNK and eIF2<i>\u03b1<\/i>\/CHOP Signal 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