{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T21:06:08Z","timestamp":1791839168276,"version":"4.3.4"},"reference-count":59,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2021,1,8]],"date-time":"2021-01-08T00:00:00Z","timestamp":1610064000000},"content-version":"vor","delay-in-days":7,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100015027","name":"Vice Chancellor for Research and Technology, Hamadan University of Medical Sciences","doi-asserted-by":"publisher","award":["9710185991"],"award-info":[{"award-number":["9710185991"]}],"id":[{"id":"10.13039\/501100015027","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Oxidative Medicine and Cellular Longevity"],"published-print":{"date-parts":[[2021,1]]},"abstract":"<jats:p>This study was undertaken to evaluate the therapeutic potential effect of pentoxifylline (PTX) against arsenic trioxide (ATO)\u2010induced cardiac oxidative damage in mice. Thirty\u2010six male albino mice were divided into six groups and treated intraperitoneally with normal saline (group 1), ATO (5\u2009mg\/kg; group 2), PTX (100\u2009mg\/kg; group 3), and different doses of PTX (25, 50, and 100\u2009mg\/kg; groups 4, 5, and 6, respectively) with ATO. After four weeks, the blood sample was collected for biochemical experiments. In addition, cardiac tissue was removed for assessment of oxidative stress markers and histopathological changes (such as hemorrhage, necrosis, infiltration of inflammatory cells, and myocardial degeneration). The findings showed that ATO caused a significant raise in serum biochemical markers such as lactate dehydrogenase (LDH), creatine phosphokinase (CPK) and troponin\u2010I (cTnI), glucose, total cholesterol (TC), and triglyceride (TG) levels. In addition to histopathological changes in cardiac tissue, ATO led to the significant increase in cardiac lipid peroxidation (LPO) and nitric oxide (NO); remarkable decrease in the activity of cardiac antioxidant enzymes such as catalase (CAT), superoxide dismutase (SOD), and glutathione peroxidase (GPx); and the depletion of the total antioxidant capacity (TAC) and total thiol groups (TTGs). PTX was able to reduce the increased levels of serum cardiac markers (LDH, CPK, cTnI, TC, and TG), cardiac LPO, and improve antioxidant markers (TAC, TTGs, CAT, SOD, and GPx) alongside histopathologic changes. However, no significant changes were observed in elevated serum glucose and cardiac NO levels. In conclusion, the current study showed the potential therapeutic effect of PTX in the prevention of ATO\u2010induced cardiotoxicity via reversing the oxidative stress.<\/jats:p>","DOI":"10.1155\/2021\/6406318","type":"journal-article","created":{"date-parts":[[2021,1,9]],"date-time":"2021-01-09T07:42:06Z","timestamp":1610178126000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":33,"title":["Pentoxifylline Attenuates Arsenic Trioxide\u2010Induced Cardiac Oxidative Damage in Mice"],"prefix":"10.1155","volume":"2021","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8452-3113","authenticated-orcid":false,"given":"Atefeh","family":"Gholami","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1211-8132","authenticated-orcid":false,"given":"Sara","family":"Ataei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3886-9935","authenticated-orcid":false,"given":"Davoud","family":"Ahmadimoghaddam","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3391-926X","authenticated-orcid":false,"given":"Navid","family":"Omidifar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9072-8318","authenticated-orcid":false,"given":"Amir","family":"Nili-Ahmadabadi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,1,8]]},"reference":[{"key":"e_1_2_8_1_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.scitotenv.2017.10.232"},{"key":"e_1_2_8_2_2","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2458-12-639"},{"key":"e_1_2_8_3_2","doi-asserted-by":"publisher","DOI":"10.1097\/ede.0000000000000313"},{"key":"e_1_2_8_4_2","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.117.018891"},{"key":"e_1_2_8_5_2","doi-asserted-by":"publisher","DOI":"10.1177\/0960327117701986"},{"key":"e_1_2_8_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2019.11.099"},{"key":"e_1_2_8_7_2","doi-asserted-by":"publisher","DOI":"10.1007\/s12012-018-09504-7"},{"key":"e_1_2_8_8_2","doi-asserted-by":"publisher","DOI":"10.1080\/15376516.2017.1422578"},{"key":"e_1_2_8_9_2","doi-asserted-by":"publisher","DOI":"10.1002\/jcp.28292"},{"key":"e_1_2_8_10_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10620-009-0780-x"},{"key":"e_1_2_8_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.etap.2013.11.025"},{"key":"e_1_2_8_12_2","doi-asserted-by":"publisher","DOI":"10.3109\/10641963.2015.1047944"},{"key":"e_1_2_8_13_2","doi-asserted-by":"publisher","DOI":"10.3923\/ajava.2011.1233.1240"},{"key":"e_1_2_8_14_2","first-page":"37","article-title":"Antioxidant effect of sildenafil on cadmium-induced liver, lung and kidney injury","volume":"45","author":"BARAN A. 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