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Angiotensin II (Ang II) is a vasoconstricting peptide hormone, and Ang II\u2010induced myocardial hypertrophy is a common cardiovascular disease that can result in heart failure. In this study, we sought to determine the role of IKK<jats:italic>\u03b5<\/jats:italic> in the development of Ang II\u2010induced myocardial hypertrophy in mice. Wild\u2010type (WT) and IKK<jats:italic>\u03b5<\/jats:italic>\u2010knockout (IKK<jats:italic>\u03b5<\/jats:italic>\u2010KO) mice were generated and infused with saline or Ang II for 8 weeks. We found that WT mouse hearts have increased IKK<jats:italic>\u03b5<\/jats:italic> expression after 8 weeks of Ang II infusion. Our results further indicated that IKK<jats:italic>\u03b5<\/jats:italic>\u2010KO mice have attenuated myocardial hypertrophy and alleviated heart failure compared with WT mice. Additionally, Ang II\u2010induced expression of proinflammatory and collagen factors was much lower in the IKK<jats:italic>\u03b5<\/jats:italic>\u2010KO mice than in the WT mice. Apoptosis and pyroptosis were also ameliorated in IKK<jats:italic>\u03b5<\/jats:italic>\u2010KO mice. Mechanistically, IKK<jats:italic>\u03b5<\/jats:italic> bound to extracellular signal\u2010regulated kinase (ERK) and the mitogen\u2010activated protein kinase p38, resulting in MAPK\/ERK kinase (MEK) phosphorylation, and IKK<jats:italic>\u03b5<\/jats:italic> deficiency inhibited the phosphorylation of MEK\u2010ERK1\/2 and p38 in mouse heart tissues after 8 weeks of Ang II infusion. The findings of our study reveal that IKK<jats:italic>\u03b5<\/jats:italic> plays an important role in the development of Ang II\u2010induced myocardial hypertrophy and may represent a potential therapeutic target for the management of myocardial hypertrophy.<\/jats:p>","DOI":"10.1155\/2021\/6429197","type":"journal-article","created":{"date-parts":[[2021,2,9]],"date-time":"2021-02-09T17:58:08Z","timestamp":1612893488000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["I\u2010<i>\u03ba<\/i>B Kinase\u2010<i>\u03b5<\/i> Deficiency Attenuates the Development of Angiotensin II\u2010Induced Myocardial Hypertrophy in 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