{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,6]],"date-time":"2026-04-06T19:20:17Z","timestamp":1775503217788,"version":"3.50.1"},"reference-count":34,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2021,10,13]],"date-time":"2021-10-13T00:00:00Z","timestamp":1634083200000},"content-version":"vor","delay-in-days":285,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004951","name":"Atat\u00fcrk \u00dcniversitesi","doi-asserted-by":"publisher","award":["2016\/50"],"award-info":[{"award-number":["2016\/50"]}],"id":[{"id":"10.13039\/501100004951","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["BioMed Research International"],"published-print":{"date-parts":[[2021,1]]},"abstract":"<jats:p>Familial Mediterranean fever (FMF) is the most prevalent autoinflammatory disease. Typical findings are recurrent fever attacks with serositis, skin rash, and synovitis. FMF is caused by mutations in the <jats:italic>MEFV<\/jats:italic> gene, encoding pyrin protein. Pyrin functions in innate immunity and triggers inflammation via inflammatory mediators\u2019 production and acts as the primary regulatory component of the inflammasome. On the other hand, various miRNAs play crucial roles in the pathogenesis of different types of cancers and immune\u2010related and neurodegenerative diseases. However, their association with FMF is still unclear. Therefore, in this study, we assessed the roles of selected thirteen miRNAs associated with immune functions. We recruited genetically diagnosed 28 FMF patients and 28 healthy individuals. The expression profiling of the miRNAs was determined by qRT\u2010PCR and normalized to <jats:italic>SNORD61<\/jats:italic>. Our analysis revealed that miR\u201034a\u20105p, miR\u2010142\u20103p, miR\u2010216a\u20105p, miR\u2010340\u20105p, miR\u2010429, and miR\u2010582\u20105p were upregulated, whereas miR\u2010107, miR\u2010569, and miR\u20101304\u20105p were downregulated in the FMF patients. Among them, miR\u2010107 was found to be the most remarkable in M694V homozygous mutants compared to other homozygous mutants. During clinical follow\u2010up of the patients with M694V mutation, which is closely related to amyloidosis, evaluation of mir\u2010107 expression might be crucial and suggestive. Our results showed that miRNAs might serve a function in the pathogenesis of FMF. Further studies may provide novel and effective diagnostic and therapeutic agents that target examined miRNAs. Targeting miRNAs in FMF seems to be promising and may yield a new generation of rational therapeutics and diagnostic or monitoring tools enabling FMF treatment.<\/jats:p>","DOI":"10.1155\/2021\/6495700","type":"journal-article","created":{"date-parts":[[2021,10,14]],"date-time":"2021-10-14T00:28:14Z","timestamp":1634171294000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["The Assessment of Selected miRNA Profile in Familial Mediterranean Fever"],"prefix":"10.1155","volume":"2021","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1957-9596","authenticated-orcid":false,"given":"Cigdem Yuce","family":"Kahraman","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4221-7051","authenticated-orcid":false,"given":"Mehmet Ertugrul","family":"Egin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7273-1679","authenticated-orcid":false,"given":"Abdulgani","family":"Tatar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7046-8990","authenticated-orcid":false,"given":"Hasan","family":"Turkez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4254-6090","authenticated-orcid":false,"given":"Adil","family":"Mardinoglu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2021,10,13]]},"reference":[{"key":"e_1_2_12_1_2","doi-asserted-by":"publisher","DOI":"10.3906\/sag-2008-11"},{"key":"e_1_2_12_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(00)80539-5"},{"key":"e_1_2_12_3_2","doi-asserted-by":"publisher","DOI":"10.1038\/ng0997-25"},{"key":"e_1_2_12_4_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00296-020-04541-4"},{"key":"e_1_2_12_5_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00011-019-01272-6"},{"key":"e_1_2_12_6_2","doi-asserted-by":"publisher","DOI":"10.1038\/ni.3777"},{"key":"e_1_2_12_7_2","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4939-6524-3_1"},{"key":"e_1_2_12_8_2","doi-asserted-by":"publisher","DOI":"10.1080\/14397595.2017.1285845"},{"key":"e_1_2_12_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.gpb.2012.07.005"},{"key":"e_1_2_12_10_2","doi-asserted-by":"publisher","DOI":"10.32607\/20758251-2016-8-1-21-33"},{"key":"e_1_2_12_11_2","doi-asserted-by":"publisher","DOI":"10.1189\/jlb.0312160"},{"key":"e_1_2_12_12_2","doi-asserted-by":"publisher","DOI":"10.1096\/fj.14-260323"},{"key":"e_1_2_12_13_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrd.2016.246"},{"key":"e_1_2_12_14_2","doi-asserted-by":"publisher","DOI":"10.3390\/cells10081988"},{"key":"e_1_2_12_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.humimm.2021.08.008"},{"key":"e_1_2_12_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuint.2021.105139"},{"key":"e_1_2_12_17_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-020-61507-z"},{"key":"e_1_2_12_18_2","doi-asserted-by":"publisher","DOI":"10.1093\/biomethods\/bpz006"},{"key":"e_1_2_12_19_2","doi-asserted-by":"publisher","DOI":"10.1002\/jcp.25602"},{"key":"e_1_2_12_20_2","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/kex451"},{"key":"e_1_2_12_21_2","first-page":"90","article-title":"Alteration of the microRNA expression profile in familial Mediterranean fever patients","volume":"35","author":"Akkaya-Ulum Y. 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