{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,6]],"date-time":"2026-01-06T13:37:51Z","timestamp":1767706671246,"version":"build-2065373602"},"reference-count":11,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2021,10,12]],"date-time":"2021-10-12T00:00:00Z","timestamp":1633996800000},"content-version":"vor","delay-in-days":284,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Case Reports in Endocrinology"],"published-print":{"date-parts":[[2021,1]]},"abstract":"<jats:p>\n                    <jats:italic>Background<\/jats:italic>\n                    . Mediastinal thyroid carcinoma is extremely rare, with few cases reported in the literature.\n                    <jats:italic>Case Report<\/jats:italic>\n                    . A 73\u2010year\u2010old man presented with weight loss for 6 months. Imaging by computed tomography (CT) documented a large mediastinal mass below the thyroid gland and pulmonary metastases. Neck ultrasound found two spongiform nodules in the right thyroid lobe, and fine\u2010needle aspiration citology (FNAC) of these nodules revealed they are benign. Endobronchial ultrasound\u2010guided needle biopsy of the mediastinal mass was compatible with papillary thyroid cancer. A few weeks later, the patient developed overt hyperthyroidism due to Graves\u2019 disease, which was treated with antithyroid drugs.\n                    <jats:sup>99m<\/jats:sup>\n                    Pertechnetate scintigraphy showed increased diffuse uptake in the thyroid parenchyma but the absence of uptake in the paratracheal mass and in the lung nodules. The patient was not considered eligible for surgical intervention or therapy with tyrosine kinase inhibitor due to tracheal and mediastinal vessel invasion and was treated with palliative radiotherapy. Two months later, restaging PET\u2010FDG showed an intense uptake in the right lobe of the thyroid gland, lymph nodes, lungs, bone, muscle, myocardial, kidney, and adrenal gland.\n                    <jats:italic>Conclusion<\/jats:italic>\n                    . In this case, thyroid carcinoma presented as a mediastinal mass with concurrent hyperthyroidism due to Graves\u2019 disease. Although uncommon, the clinicians should be aware of these situations. Obtaining a prompt histological examination of an intrathoracic mass is crucial to ensure an early diagnosis and treatment.\n                  <\/jats:p>","DOI":"10.1155\/2021\/6584616","type":"journal-article","created":{"date-parts":[[2021,10,12]],"date-time":"2021-10-12T21:41:27Z","timestamp":1634074887000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Mediastinal Thyroid Carcinoma and Graves\u2019 Disease: A Rare Presentation"],"prefix":"10.1155","volume":"2021","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0481-8494","authenticated-orcid":false,"given":"Sara","family":"Lomelino Pinheiro","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5181-669X","authenticated-orcid":false,"given":"In\u00eas","family":"Dam\u00e1sio","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1686-0163","authenticated-orcid":false,"given":"Ana","family":"Figueiredo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1958-4531","authenticated-orcid":false,"given":"Tiago","family":"Nunes da Silva","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5479-7332","authenticated-orcid":false,"given":"Valeriano","family":"Leite","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2021,10,12]]},"reference":[{"doi-asserted-by":"publisher","key":"e_1_2_8_1_2","DOI":"10.7759\/cureus.9541"},{"doi-asserted-by":"publisher","key":"e_1_2_8_2_2","DOI":"10.7508\/aojnmb.2013.01.009"},{"doi-asserted-by":"publisher","key":"e_1_2_8_3_2","DOI":"10.1093\/jscr\/rjz029"},{"doi-asserted-by":"publisher","key":"e_1_2_8_4_2","DOI":"10.1210\/jc.2011-0611"},{"doi-asserted-by":"publisher","key":"e_1_2_8_5_2","DOI":"10.1089\/thy.2015.0375"},{"doi-asserted-by":"publisher","key":"e_1_2_8_6_2","DOI":"10.5146\/tjpath.2015.01314"},{"doi-asserted-by":"publisher","key":"e_1_2_8_7_2","DOI":"10.1677\/erc.0.0080071"},{"doi-asserted-by":"publisher","key":"e_1_2_8_8_2","DOI":"10.5334\/jbsr.1604"},{"doi-asserted-by":"publisher","key":"e_1_2_8_9_2","DOI":"10.1186\/s13104-016-2178-0"},{"doi-asserted-by":"publisher","key":"e_1_2_8_10_2","DOI":"10.1530\/erc-19-0129"},{"doi-asserted-by":"publisher","key":"e_1_2_8_11_2","DOI":"10.1148\/rg.234025716"}],"container-title":["Case Reports in Endocrinology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/crie\/2021\/6584616.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/crie\/2021\/6584616.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1155\/2021\/6584616","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,7]],"date-time":"2025-11-07T00:06:39Z","timestamp":1762473999000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1155\/2021\/6584616"}},"subtitle":[],"editor":[{"given":"Wayne V.","family":"Moore","sequence":"additional","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2021,1]]},"references-count":11,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2021,1]]}},"alternative-id":["10.1155\/2021\/6584616"],"URL":"https:\/\/doi.org\/10.1155\/2021\/6584616","archive":["Portico"],"relation":{},"ISSN":["2090-6501","2090-651X"],"issn-type":[{"type":"print","value":"2090-6501"},{"type":"electronic","value":"2090-651X"}],"subject":[],"published":{"date-parts":[[2021,1]]},"assertion":[{"value":"2021-08-02","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-10-05","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-10-12","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"6584616"}}