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However, there are few effective and nontoxic radiation countermeasures for the radiation injury. In the current study, mice were pretreated with a traditional antimicrobial agent, FZD, before TBI; the protective effects of FZD on radiation injury were evaluated by using parameters such as the spleen index and thymus index, immunohistochemical staining of intestinal tissue, and frequency of micronuclei in polychromatophilic erythrocytes of bone marrow. The intestinal epithelial cell line IEC\u20106 was used to investigate the underlying mechanisms. Our results indicated that FZD administration significantly improved the survival of lethal dose\u2010irradiated mice, decreased the number of micronuclei, upregulated the number of leukocytes and immune organ indices, and restored intestinal integrity in mice after TBI. TUNEL and western blot showed that FZD protected intestinal tissue by downregulating radiation\u2010induced apoptosis and autophagy. Meanwhile, FZD protected IEC\u20106 cells from radiation\u2010induced cell death by inhibiting apoptosis and autophagy. To sum up, FZD protected against radiation\u2010induced cell death both in vitro and in vivo through antiapoptosis and antiautophagy mechanisms.<\/jats:p>","DOI":"10.1155\/2021\/6610726","type":"journal-article","created":{"date-parts":[[2021,2,4]],"date-time":"2021-02-04T21:36:51Z","timestamp":1612474611000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Furazolidone Increases Survival of Mice Exposed to Lethal Total Body Irradiation through the Antiapoptosis and Antiautophagy Mechanism"],"prefix":"10.1155","volume":"2021","author":[{"given":"Shumei","family":"Ma","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhao","family":"Jin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yi","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lin","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hao","family":"Feng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ping","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhujun","family":"Tian","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8736-1180","authenticated-orcid":false,"given":"Minghua","family":"Ren","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6879-990X","authenticated-orcid":false,"given":"Xiaodong","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2021,2,4]]},"reference":[{"key":"e_1_2_11_1_2","doi-asserted-by":"publisher","DOI":"10.2147\/IJGM.S22177"},{"key":"e_1_2_11_2_2","doi-asserted-by":"publisher","DOI":"10.7556\/jaoa.2014.138"},{"key":"e_1_2_11_3_2","doi-asserted-by":"publisher","DOI":"10.1038\/srep01038"},{"key":"e_1_2_11_4_2","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2017.00613"},{"key":"e_1_2_11_5_2","doi-asserted-by":"publisher","DOI":"10.3390\/ijms17111939"},{"key":"e_1_2_11_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2009.11.026"},{"key":"e_1_2_11_7_2","first-page":"572","article-title":"Efficacy of triple versus quadruple furazolidone-based eradication regimens for Helicobacter pylori infection","volume":"94","author":"L\u00fc Z.","year":"2014","journal-title":"Zhonghua Yi Xue Za Zhi"},{"key":"e_1_2_11_8_2","first-page":"3496","article-title":"Efficacy of furazolidone-based quadruple therapy as rescue treatment for refractory Helicobacter pylori infection","volume":"93","author":"Zheng X. 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