{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T22:24:40Z","timestamp":1790547880983,"version":"4.1.0"},"reference-count":312,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2021,2,10]],"date-time":"2021-02-10T00:00:00Z","timestamp":1612915200000},"content-version":"vor","delay-in-days":40,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003042","name":"Else Kr\u00f6ner-Fresenius-Stiftung","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003042","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Oxidative Medicine and Cellular Longevity"],"published-print":{"date-parts":[[2021,1]]},"abstract":"<jats:p>Aging is a natural life process which leads to a gradual decline of essential physiological processes. For the liver, it leads to alterations in histomorphology (steatosis and fibrosis) and function (protein synthesis and energy generation) and affects central hepatocellular processes (autophagy, mitochondrial respiration, and hepatocyte proliferation). These alterations do not only impair the metabolic capacity of the liver but also represent important factors in the pathogenesis of malignant liver disease. Autophagy is a recycling process for eukaryotic cells to degrade dysfunctional intracellular components and to reuse the basic substances. It plays a crucial role in maintaining cell homeostasis and in resisting environmental stress. Emerging evidence shows that modulating autophagy seems to be effective in improving the age\u2010related alterations of the liver. However, autophagy is a double\u2010edged sword for the aged liver. Upregulating autophagy alleviates hepatic steatosis and ROS\u2010induced cellular stress and promotes hepatocyte proliferation but may aggravate hepatic fibrosis. Therefore, a well\u2010balanced autophagy modulation strategy might be suitable to alleviate age\u2010related liver dysfunction. <jats:italic>Conclusion<\/jats:italic>. Modulation of autophagy is a promising strategy for \u201crejuvenation\u201d of the aged liver. Detailed knowledge regarding the most devastating processes in the individual patient is needed to effectively counteract aging of the liver without causing obvious harm.<\/jats:p>","DOI":"10.1155\/2021\/6611126","type":"journal-article","created":{"date-parts":[[2021,2,10]],"date-time":"2021-02-10T19:50:59Z","timestamp":1612986659000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["Modulation of Autophagy: A Novel \u201cRejuvenation\u201d Strategy for the Aging Liver"],"prefix":"10.1155","volume":"2021","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6523-804X","authenticated-orcid":false,"given":"Fengming","family":"Xu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hans-Michael","family":"Tautenhahn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olaf","family":"Dirsch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3483-3388","authenticated-orcid":false,"given":"Uta","family":"Dahmen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,2,10]]},"reference":[{"key":"e_1_2_12_1_2","volume-title":"World Population Ageing 2019 Highlights","author":"D. o. E. a. S. A. United Nations, Population Division","year":"2019"},{"key":"e_1_2_12_2_2","doi-asserted-by":"publisher","DOI":"10.1111\/acel.12128"},{"key":"e_1_2_12_3_2","doi-asserted-by":"publisher","DOI":"10.18632\/aging.101524"},{"key":"e_1_2_12_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.csbj.2019.07.021"},{"key":"e_1_2_12_5_2","doi-asserted-by":"publisher","DOI":"10.1097\/MOG.0000000000000176"},{"key":"e_1_2_12_6_2","doi-asserted-by":"publisher","DOI":"10.4161\/auto.25063"},{"key":"e_1_2_12_7_2","doi-asserted-by":"publisher","DOI":"10.4161\/auto.7.7.15371"},{"key":"e_1_2_12_8_2","doi-asserted-by":"publisher","DOI":"10.3390\/cells7120278"},{"key":"e_1_2_12_9_2","doi-asserted-by":"publisher","DOI":"10.3390\/cells8010016"},{"key":"e_1_2_12_10_2","doi-asserted-by":"publisher","DOI":"10.1111\/acel.12708"},{"key":"e_1_2_12_11_2","doi-asserted-by":"publisher","DOI":"10.1111\/acel.12876"},{"key":"e_1_2_12_12_2","doi-asserted-by":"publisher","DOI":"10.3390\/ijms21103606"},{"key":"e_1_2_12_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cardiores.2005.08.014"},{"key":"e_1_2_12_14_2","doi-asserted-by":"publisher","DOI":"10.4161\/auto.1.3.2017"},{"key":"e_1_2_12_15_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1432-1033.2002.02869.x"},{"key":"e_1_2_12_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2007.01.008"},{"key":"e_1_2_12_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.arr.2016.04.003"},{"key":"e_1_2_12_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.arr.2011.12.005"},{"key":"e_1_2_12_19_2","doi-asserted-by":"publisher","DOI":"10.1080\/15592294.2016.1144007"},{"key":"e_1_2_12_20_2","doi-asserted-by":"publisher","DOI":"10.1155\/2016\/3565127"},{"key":"e_1_2_12_21_2","doi-asserted-by":"publisher","DOI":"10.1002\/path.2697"},{"key":"e_1_2_12_22_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-genet-102808-114910"},{"key":"e_1_2_12_23_2","doi-asserted-by":"publisher","DOI":"10.1242\/jcs.215152"},{"key":"e_1_2_12_24_2","doi-asserted-by":"publisher","DOI":"10.1155\/2018\/8602041"},{"key":"e_1_2_12_25_2","doi-asserted-by":"publisher","DOI":"10.1089\/ars.2013.5371"},{"key":"e_1_2_12_26_2","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.200803137"},{"key":"e_1_2_12_27_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1523145113"},{"key":"e_1_2_12_28_2","doi-asserted-by":"publisher","DOI":"10.4161\/auto.6.8.13428"},{"key":"e_1_2_12_29_2","doi-asserted-by":"publisher","DOI":"10.1038\/ncb2078"},{"key":"e_1_2_12_30_2","doi-asserted-by":"publisher","DOI":"10.1038\/ncb0810-735"},{"key":"e_1_2_12_31_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2010.04.009"},{"key":"e_1_2_12_32_2","doi-asserted-by":"publisher","DOI":"10.1091\/mbc.e09-04-0345"},{"key":"e_1_2_12_33_2","doi-asserted-by":"publisher","DOI":"10.4161\/auto.6.6.12575"},{"key":"e_1_2_12_34_2","doi-asserted-by":"publisher","DOI":"10.1080\/15548627.2015.1017178"},{"key":"e_1_2_12_35_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.devcel.2013.04.004"},{"key":"e_1_2_12_36_2","doi-asserted-by":"publisher","DOI":"10.1038\/cr.2017.4"},{"key":"e_1_2_12_37_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ceb.2016.02.010"},{"key":"e_1_2_12_38_2","doi-asserted-by":"publisher","DOI":"10.4161\/auto.5.7.9296"},{"key":"e_1_2_12_39_2","doi-asserted-by":"publisher","DOI":"10.1080\/15548627.2018.1504716"},{"key":"e_1_2_12_40_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41580-018-0003-4"},{"key":"e_1_2_12_41_2","doi-asserted-by":"publisher","DOI":"10.1038\/ncb2757"},{"key":"e_1_2_12_42_2","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.129.2.321"},{"key":"e_1_2_12_43_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.C700195200"},{"key":"e_1_2_12_44_2","doi-asserted-by":"publisher","DOI":"10.1091\/mbc.e07-12-1257"},{"key":"e_1_2_12_45_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.febslet.2010.02.017"},{"key":"e_1_2_12_46_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2011.10.026"},{"key":"e_1_2_12_47_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1615455113"},{"key":"e_1_2_12_48_2","doi-asserted-by":"publisher","DOI":"10.1242\/jcs.196352"},{"key":"e_1_2_12_49_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.273.34.21883"},{"key":"e_1_2_12_50_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmb.2019.10.028"},{"key":"e_1_2_12_51_2","doi-asserted-by":"publisher","DOI":"10.1242\/jcs.01114"},{"key":"e_1_2_12_52_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cellsig.2010.09.012"},{"key":"e_1_2_12_53_2","doi-asserted-by":"publisher","DOI":"10.3390\/cells5030034"},{"key":"e_1_2_12_54_2","doi-asserted-by":"publisher","DOI":"10.1242\/jcs.01370"},{"key":"e_1_2_12_55_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2012.11.001"},{"key":"e_1_2_12_56_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1193497"},{"key":"e_1_2_12_57_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.redox.2012.11.008"},{"key":"e_1_2_12_58_2","doi-asserted-by":"publisher","DOI":"10.3389\/fcell.2019.00185"},{"key":"e_1_2_12_59_2","doi-asserted-by":"publisher","DOI":"10.1002\/jcp.27988"},{"key":"e_1_2_12_60_2","doi-asserted-by":"publisher","DOI":"10.1080\/15548627.2020.1728097"},{"key":"e_1_2_12_61_2","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.202004029"},{"key":"e_1_2_12_62_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41556-018-0176-2"},{"key":"e_1_2_12_63_2","doi-asserted-by":"publisher","DOI":"10.3390\/cells9040831"},{"key":"e_1_2_12_64_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cub.2018.01.004"},{"key":"e_1_2_12_65_2","doi-asserted-by":"publisher","DOI":"10.1242\/jcs.093849"},{"key":"e_1_2_12_66_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrgastro.2013.211"},{"key":"e_1_2_12_67_2","doi-asserted-by":"publisher","DOI":"10.1242\/jcs.246322"},{"key":"e_1_2_12_68_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00018-011-0865-5"},{"key":"e_1_2_12_69_2","doi-asserted-by":"publisher","DOI":"10.1242\/jcs.073874"},{"key":"e_1_2_12_70_2","doi-asserted-by":"publisher","DOI":"10.1016\/b978-0-12-405530-8.00012-1"},{"key":"e_1_2_12_71_2","doi-asserted-by":"publisher","DOI":"10.1038\/cr.2013.153"},{"key":"e_1_2_12_72_2","doi-asserted-by":"publisher","DOI":"10.1016\/bs.mie.2016.10.009"},{"key":"e_1_2_12_73_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-nutr-071813-105336"},{"key":"e_1_2_12_74_2","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.200412022"},{"key":"e_1_2_12_75_2","first-page":"165","volume-title":"Autophagy-A Double-Edged Sword-Cell Survival or Death","author":"Bhogal R. H.","year":"2013"},{"key":"e_1_2_12_76_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2011.04.004"},{"key":"e_1_2_12_77_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(19)69010-1"},{"key":"e_1_2_12_78_2","doi-asserted-by":"publisher","DOI":"10.1093\/toxsci\/kfs133"},{"key":"e_1_2_12_79_2","doi-asserted-by":"publisher","DOI":"10.1155\/2020\/6946037"},{"key":"e_1_2_12_80_2","doi-asserted-by":"publisher","DOI":"10.1096\/fj.201801234r"},{"key":"e_1_2_12_81_2","doi-asserted-by":"publisher","DOI":"10.3389\/fgene.2012.00148"},{"key":"e_1_2_12_82_2","doi-asserted-by":"publisher","DOI":"10.1590\/0001-3765202020200437"},{"key":"e_1_2_12_83_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13048-020-0615-0"},{"key":"e_1_2_12_84_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1009485107"},{"key":"e_1_2_12_85_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2011.07.030"},{"key":"e_1_2_12_86_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11357-011-9221-9"},{"key":"e_1_2_12_87_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2006.01.016"},{"key":"e_1_2_12_88_2","doi-asserted-by":"publisher","DOI":"10.4161\/cc.8.24.10310"},{"key":"e_1_2_12_89_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00018-008-7581-9"},{"key":"e_1_2_12_90_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1699-0463.1998.tb01346.x"},{"key":"e_1_2_12_91_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.redox.2013.01.006"},{"key":"e_1_2_12_92_2","doi-asserted-by":"publisher","DOI":"10.1089\/ars.2009.2598"},{"key":"e_1_2_12_93_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0059638"},{"key":"e_1_2_12_94_2","doi-asserted-by":"publisher","DOI":"10.1002\/path.2094"},{"key":"e_1_2_12_95_2","doi-asserted-by":"publisher","DOI":"10.3389\/fnins.2018.00464"},{"key":"e_1_2_12_96_2","doi-asserted-by":"publisher","DOI":"10.1042\/CS20190672"},{"key":"e_1_2_12_97_2","first-page":"83","article-title":"Podocytopathy","volume":"183","author":"Liu Z.-H.","year":"2014","journal-title":"Contributions to Nephrology"},{"key":"e_1_2_12_98_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2017.02.004"},{"key":"e_1_2_12_99_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(03)00929-2"},{"key":"e_1_2_12_100_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1748-1716.2009.01972.x"},{"key":"e_1_2_12_101_2","doi-asserted-by":"publisher","DOI":"10.1007\/s12154-008-0008-0"},{"key":"e_1_2_12_102_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI44203"},{"key":"e_1_2_12_103_2","doi-asserted-by":"publisher","DOI":"10.1042\/EBC20170027"},{"key":"e_1_2_12_104_2","doi-asserted-by":"publisher","DOI":"10.1038\/ncb2152"},{"key":"e_1_2_12_105_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41589-019-0320-8"},{"key":"e_1_2_12_106_2","doi-asserted-by":"publisher","DOI":"10.4161\/auto.7.6.15123"},{"key":"e_1_2_12_107_2","doi-asserted-by":"publisher","DOI":"10.1038\/ncb1183"},{"key":"e_1_2_12_108_2","doi-asserted-by":"publisher","DOI":"10.1126\/scisignal.aav3249"},{"key":"e_1_2_12_109_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2017.04.001"},{"key":"e_1_2_12_110_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.C200510200"},{"key":"e_1_2_12_111_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M204802200"},{"key":"e_1_2_12_112_2","doi-asserted-by":"publisher","DOI":"10.1038\/nm.3232"},{"key":"e_1_2_12_113_2","doi-asserted-by":"publisher","DOI":"10.1042\/bj3440427"},{"key":"e_1_2_12_114_2","doi-asserted-by":"publisher","DOI":"10.1101\/cshperspect.a011189"},{"key":"e_1_2_12_115_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M900573200"},{"key":"e_1_2_12_116_2","doi-asserted-by":"publisher","DOI":"10.1091\/mbc.e08-12-1249"},{"key":"e_1_2_12_117_2","doi-asserted-by":"publisher","DOI":"10.1091\/mbc.e08-12-1248"},{"key":"e_1_2_12_118_2","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.01344-09"},{"key":"e_1_2_12_119_2","doi-asserted-by":"publisher","DOI":"10.2147\/rrb.s90858"},{"key":"e_1_2_12_120_2","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.05565-11"},{"key":"e_1_2_12_121_2","doi-asserted-by":"publisher","DOI":"10.1038\/cdd.2008.131"},{"key":"e_1_2_12_122_2","doi-asserted-by":"publisher","DOI":"10.1101\/cshperspect.a026120"},{"key":"e_1_2_12_123_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ceb.2009.12.001"},{"key":"e_1_2_12_124_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2006.05.034"},{"key":"e_1_2_12_125_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0502857102"},{"key":"e_1_2_12_126_2","doi-asserted-by":"publisher","DOI":"10.1038\/ncb1730"},{"key":"e_1_2_12_127_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2017.07.049"},{"key":"e_1_2_12_128_2","doi-asserted-by":"publisher","DOI":"10.1038\/onc.2012.640"},{"key":"e_1_2_12_129_2","doi-asserted-by":"publisher","DOI":"10.1101\/gad.196238.112"},{"key":"e_1_2_12_130_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41419-018-0529-6"},{"key":"e_1_2_12_131_2","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.200504035"},{"key":"e_1_2_12_132_2","doi-asserted-by":"publisher","DOI":"10.1038\/cdd.2008.110"},{"key":"e_1_2_12_133_2","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2017.00140"},{"key":"e_1_2_12_134_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2010.06.007"},{"key":"e_1_2_12_135_2","doi-asserted-by":"publisher","DOI":"10.1074\/mcp.M116.060145"},{"key":"e_1_2_12_136_2","doi-asserted-by":"publisher","DOI":"10.1002\/hep.21060"},{"key":"e_1_2_12_137_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0083-6729(06)75006-3"},{"key":"e_1_2_12_138_2","doi-asserted-by":"publisher","DOI":"10.1038\/cmi.2016.5"},{"key":"e_1_2_12_139_2","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v23.i43.7666"},{"key":"e_1_2_12_140_2","doi-asserted-by":"publisher","DOI":"10.1002\/cphy.c120026"},{"key":"e_1_2_12_141_2","doi-asserted-by":"publisher","DOI":"10.1093\/gerona\/53A.2.B111"},{"key":"e_1_2_12_142_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.exger.2003.07.002"},{"key":"e_1_2_12_143_2","first-page":"36","article-title":"The impact of aging on the liver","volume":"6","author":"Stell D.","year":"2003","journal-title":"Geriatrics and Aging"},{"key":"e_1_2_12_144_2","doi-asserted-by":"publisher","DOI":"10.1002\/hep.1840090222"},{"key":"e_1_2_12_145_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbalip.2011.09.017"},{"key":"e_1_2_12_146_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1665-2681(19)32187-8"},{"key":"e_1_2_12_147_2","doi-asserted-by":"publisher","DOI":"10.1002\/hep.28431"},{"key":"e_1_2_12_148_2","doi-asserted-by":"publisher","DOI":"10.1309\/RTPM1PY6YGBL2G2R"},{"key":"e_1_2_12_149_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cld.2017.08.007"},{"key":"e_1_2_12_150_2","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2019.00926"},{"key":"e_1_2_12_151_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2018.07.014"},{"key":"e_1_2_12_152_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2012.07.028"},{"key":"e_1_2_12_153_2","doi-asserted-by":"publisher","DOI":"10.1097\/TP.0000000000002480"},{"key":"e_1_2_12_154_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2011.08.012"},{"key":"e_1_2_12_155_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.livres.2020.02.004"},{"key":"e_1_2_12_156_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbadis.2014.06.025"},{"key":"e_1_2_12_157_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrm.2017.76"},{"key":"e_1_2_12_158_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature07976"},{"key":"e_1_2_12_159_2","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2019.01077"},{"key":"e_1_2_12_160_2","doi-asserted-by":"publisher","DOI":"10.4161\/auto.8.2.18554"},{"key":"e_1_2_12_161_2","doi-asserted-by":"publisher","DOI":"10.1038\/cdd.2012.63"},{"key":"e_1_2_12_162_2","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2015.09.042"},{"key":"e_1_2_12_163_2","doi-asserted-by":"publisher","DOI":"10.3390\/ijms15058713"},{"key":"e_1_2_12_164_2","doi-asserted-by":"publisher","DOI":"10.1242\/jcs.134130"},{"key":"e_1_2_12_165_2","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms15691"},{"key":"e_1_2_12_166_2","doi-asserted-by":"publisher","DOI":"10.1042\/bj1340707"},{"key":"e_1_2_12_167_2","doi-asserted-by":"publisher","DOI":"10.4137\/JCD.S39824"},{"key":"e_1_2_12_168_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cca.2011.04.013"},{"key":"e_1_2_12_169_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2020.02.025"},{"key":"e_1_2_12_170_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.molcel.2015.10.009"},{"key":"e_1_2_12_171_2","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-642-14426-4_4"},{"key":"e_1_2_12_172_2","doi-asserted-by":"publisher","DOI":"10.3390\/ijms17030387"},{"key":"e_1_2_12_173_2","doi-asserted-by":"publisher","DOI":"10.1142\/S0192415X16500671"},{"key":"e_1_2_12_174_2","doi-asserted-by":"publisher","DOI":"10.3390\/cells8040348"},{"key":"e_1_2_12_175_2","doi-asserted-by":"publisher","DOI":"10.1126\/scisignal.aac5472"},{"key":"e_1_2_12_176_2","doi-asserted-by":"publisher","DOI":"10.18632\/aging.102396"},{"key":"e_1_2_12_177_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2013.01.011"},{"key":"e_1_2_12_178_2","doi-asserted-by":"publisher","DOI":"10.1249\/JES.0000000000000116"},{"key":"e_1_2_12_179_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41419-019-1458-8"},{"key":"e_1_2_12_180_2","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2019.00494"},{"key":"e_1_2_12_181_2","doi-asserted-by":"publisher","DOI":"10.1155\/2019\/4825949"},{"key":"e_1_2_12_182_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0210068"},{"key":"e_1_2_12_183_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-018-22339-0"},{"key":"e_1_2_12_184_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbalip.2018.03.001"},{"key":"e_1_2_12_185_2","doi-asserted-by":"publisher","DOI":"10.1039\/C8RA02849D"},{"key":"e_1_2_12_186_2","doi-asserted-by":"publisher","DOI":"10.1002\/oby.21757"},{"key":"e_1_2_12_187_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.mce.2015.09.027"},{"key":"e_1_2_12_188_2","doi-asserted-by":"publisher","DOI":"10.1002\/mnfr.201500016"},{"key":"e_1_2_12_189_2","doi-asserted-by":"publisher","DOI":"10.1097\/MOG.0b013e3283279668"},{"key":"e_1_2_12_190_2","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2018.02795"},{"key":"e_1_2_12_191_2","unstructured":"Netinbag What are stellate cells? 2020 August 2020 https:\/\/www.netinbag.com\/en\/physiology\/what-are-stellate-cells.html."},{"key":"e_1_2_12_192_2","first-page":"34","article-title":"Role of hepatic stellate cells in the pathogenesis of portal hypertension","volume":"22","author":"Marra F.","year":"2002","journal-title":"Nefrolog\u00eda"},{"key":"e_1_2_12_193_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrgastro.2017.38"},{"key":"e_1_2_12_194_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajpgi.2000.279.1.G7"},{"key":"e_1_2_12_195_2","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v22.i48.10512"},{"key":"e_1_2_12_196_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bpg.2011.02.005"},{"key":"e_1_2_12_197_2","doi-asserted-by":"publisher","DOI":"10.1155\/2017\/6824762"},{"key":"e_1_2_12_198_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2011.07.010"},{"key":"e_1_2_12_199_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0034945"},{"key":"e_1_2_12_200_2","doi-asserted-by":"publisher","DOI":"10.1155\/2014\/436242"},{"key":"e_1_2_12_201_2","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2011.12.044"},{"key":"e_1_2_12_202_2","doi-asserted-by":"publisher","DOI":"10.1247\/csf.23.33"},{"key":"e_1_2_12_203_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.redox.2016.11.004"},{"key":"e_1_2_12_204_2","doi-asserted-by":"publisher","DOI":"10.1248\/bpb.b14-00297"},{"key":"e_1_2_12_205_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0016-5085(99)70406-3"},{"key":"e_1_2_12_206_2","first-page":"2833","article-title":"Rapamycin inhibits spontaneous and fibroblast growth factor beta-stimulated proliferation of endothelial cells and fibroblasts","volume":"23","author":"Akselband Y.","year":"1991","journal-title":"Transplantation Proceedings"},{"key":"e_1_2_12_207_2","doi-asserted-by":"publisher","DOI":"10.1042\/BSR20181822"},{"key":"e_1_2_12_208_2","doi-asserted-by":"publisher","DOI":"10.5500\/wjt.v3.i3.36"},{"key":"e_1_2_12_209_2","doi-asserted-by":"publisher","DOI":"10.1258\/ebm.2011.010360"},{"key":"e_1_2_12_210_2","doi-asserted-by":"publisher","DOI":"10.1002\/hep.24690"},{"key":"e_1_2_12_211_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2019.01.026"},{"key":"e_1_2_12_212_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0168-8278(18)30276-9"},{"key":"e_1_2_12_213_2","doi-asserted-by":"publisher","DOI":"10.1080\/15548627.2015.1058473"},{"key":"e_1_2_12_214_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2018.10.015"},{"key":"e_1_2_12_215_2","doi-asserted-by":"publisher","DOI":"10.1101\/gad.1599207"},{"key":"e_1_2_12_216_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.110.237339"},{"key":"e_1_2_12_217_2","doi-asserted-by":"publisher","DOI":"10.17219\/acem\/122175"},{"key":"e_1_2_12_218_2","doi-asserted-by":"publisher","DOI":"10.1155\/2019\/6175091"},{"key":"e_1_2_12_219_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2018.10.005"},{"key":"e_1_2_12_220_2","doi-asserted-by":"publisher","DOI":"10.2147\/DDDT.S162950"},{"key":"e_1_2_12_221_2","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.22539"},{"key":"e_1_2_12_222_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-017-09673-5"},{"key":"e_1_2_12_223_2","doi-asserted-by":"publisher","DOI":"10.3390\/ijms160921911"},{"key":"e_1_2_12_224_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2018.04.156"},{"key":"e_1_2_12_225_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.276.5309.60"},{"key":"e_1_2_12_226_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrm1489"},{"key":"e_1_2_12_227_2","doi-asserted-by":"publisher","DOI":"10.1038\/s12276-020-0483-0"},{"key":"e_1_2_12_228_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0168-8278(00)80412-2"},{"key":"e_1_2_12_229_2","doi-asserted-by":"publisher","DOI":"10.2183\/pjab.86.588"},{"key":"e_1_2_12_230_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF02782887"},{"key":"e_1_2_12_231_2","doi-asserted-by":"publisher","DOI":"10.1002\/hep.1840130422"},{"key":"e_1_2_12_232_2","doi-asserted-by":"publisher","DOI":"10.15761\/ghe.1000183"},{"key":"e_1_2_12_233_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9440(10)65637-4"},{"key":"e_1_2_12_234_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.86.5.1558"},{"key":"e_1_2_12_235_2","doi-asserted-by":"publisher","DOI":"10.1055\/s-2005-858989"},{"key":"e_1_2_12_236_2","doi-asserted-by":"publisher","DOI":"10.1155\/2017\/4256352"},{"key":"e_1_2_12_237_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.85.5.1539"},{"key":"e_1_2_12_238_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M202403200"},{"key":"e_1_2_12_239_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cytogfr.2006.01.001"},{"key":"e_1_2_12_240_2","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gfh1034"},{"key":"e_1_2_12_241_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jss.2005.01.002"},{"key":"e_1_2_12_242_2","doi-asserted-by":"publisher","DOI":"10.1186\/1478-811X-12-18"},{"key":"e_1_2_12_243_2","doi-asserted-by":"publisher","DOI":"10.1002\/hep.1840200413"},{"key":"e_1_2_12_244_2","doi-asserted-by":"publisher","DOI":"10.1053\/jhep.1997.v26.pm0009214451"},{"key":"e_1_2_12_245_2","doi-asserted-by":"publisher","DOI":"10.1016\/0014-4827(88)90286-8"},{"key":"e_1_2_12_246_2","doi-asserted-by":"publisher","DOI":"10.1093\/carcin\/8.11.1737"},{"key":"e_1_2_12_247_2","doi-asserted-by":"publisher","DOI":"10.18632\/aging.101232"},{"key":"e_1_2_12_248_2","doi-asserted-by":"publisher","DOI":"10.1002\/hep.26753"},{"key":"e_1_2_12_249_2","doi-asserted-by":"publisher","DOI":"10.1096\/fasebj.10.11.8836038"},{"key":"e_1_2_12_250_2","doi-asserted-by":"publisher","DOI":"10.1093\/qjmed\/hcu013"},{"key":"e_1_2_12_251_2","doi-asserted-by":"publisher","DOI":"10.1159\/000430287"},{"key":"e_1_2_12_252_2","doi-asserted-by":"publisher","DOI":"10.1155\/2011\/526379"},{"key":"e_1_2_12_253_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10620-018-5346-3"},{"key":"e_1_2_12_254_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.alcohol.2007.04.008"},{"key":"e_1_2_12_255_2","doi-asserted-by":"publisher","DOI":"10.1096\/fj.201700153R"},{"key":"e_1_2_12_256_2","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-319-73344-9_8"},{"key":"e_1_2_12_257_2","doi-asserted-by":"publisher","DOI":"10.1002\/hep.27140"},{"key":"e_1_2_12_258_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00428-008-0604-y"},{"key":"e_1_2_12_259_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M007758200"},{"key":"e_1_2_12_260_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2013.07.018"},{"key":"e_1_2_12_261_2","doi-asserted-by":"publisher","DOI":"10.15252\/emmm.201404137"},{"key":"e_1_2_12_262_2","doi-asserted-by":"publisher","DOI":"10.1111\/cns.12855"},{"key":"e_1_2_12_263_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ceca.2017.08.005"},{"key":"e_1_2_12_264_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0052347"},{"key":"e_1_2_12_265_2","doi-asserted-by":"publisher","DOI":"10.1038\/srep15807"},{"key":"e_1_2_12_266_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2019.02.013"},{"key":"e_1_2_12_267_2","doi-asserted-by":"publisher","DOI":"10.12659\/MSM.915404"},{"key":"e_1_2_12_268_2","doi-asserted-by":"publisher","DOI":"10.1038\/emm.2017.140"},{"key":"e_1_2_12_269_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-018-36208-3"},{"key":"e_1_2_12_270_2","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.91.3.227s"},{"key":"e_1_2_12_271_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbabio.2016.01.013"},{"key":"e_1_2_12_272_2","doi-asserted-by":"publisher","DOI":"10.1042\/EBC20170098"},{"key":"e_1_2_12_273_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI64125"},{"key":"e_1_2_12_274_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbamcr.2016.09.012"},{"key":"e_1_2_12_275_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.00226.2004"},{"key":"e_1_2_12_276_2","doi-asserted-by":"publisher","DOI":"10.1016\/0006-291X(89)92701-0"},{"key":"e_1_2_12_277_2","doi-asserted-by":"publisher","DOI":"10.1002\/hep.510240536"},{"key":"e_1_2_12_278_2","doi-asserted-by":"publisher","DOI":"10.1038\/ng0398-231"},{"key":"e_1_2_12_279_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0005-2728(98)00120-0"},{"key":"e_1_2_12_280_2","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkp100"},{"key":"e_1_2_12_281_2","doi-asserted-by":"publisher","DOI":"10.1038\/ng1988"},{"key":"e_1_2_12_282_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.exger.2007.10.001"},{"key":"e_1_2_12_283_2","doi-asserted-by":"publisher","DOI":"10.3390\/genes8120398"},{"key":"e_1_2_12_284_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature02517"},{"key":"e_1_2_12_285_2","doi-asserted-by":"publisher","DOI":"10.1042\/EBC20170104"},{"key":"e_1_2_12_286_2","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.00030.2008"},{"key":"e_1_2_12_287_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41556-018-0133-0"},{"key":"e_1_2_12_288_2","doi-asserted-by":"publisher","DOI":"10.1186\/1741-7007-12-35"},{"key":"e_1_2_12_289_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.redox.2014.11.006"},{"key":"e_1_2_12_290_2","doi-asserted-by":"publisher","DOI":"10.1080\/15548627.2015.1061172"},{"key":"e_1_2_12_291_2","doi-asserted-by":"publisher","DOI":"10.1089\/dna.2018.4348"},{"key":"e_1_2_12_292_2","doi-asserted-by":"publisher","DOI":"10.3389\/fcell.2020.00200"},{"key":"e_1_2_12_293_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ceb.2015.01.002"},{"key":"e_1_2_12_294_2","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms2016"},{"key":"e_1_2_12_295_2","doi-asserted-by":"publisher","DOI":"10.1038\/icb.2014.75"},{"key":"e_1_2_12_296_2","doi-asserted-by":"publisher","DOI":"10.1098\/rsob.120080"},{"key":"e_1_2_12_297_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12915-017-0470-7"},{"key":"e_1_2_12_298_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M113.509653"},{"key":"e_1_2_12_299_2","doi-asserted-by":"publisher","DOI":"10.3390\/nu8010027"},{"key":"e_1_2_12_300_2","doi-asserted-by":"publisher","DOI":"10.1111\/jpi.12450"},{"key":"e_1_2_12_301_2","doi-asserted-by":"publisher","DOI":"10.1002\/mnfr.201900390"},{"key":"e_1_2_12_302_2","doi-asserted-by":"publisher","DOI":"10.1038\/nm.4132"},{"key":"e_1_2_12_303_2","doi-asserted-by":"publisher","DOI":"10.1038\/s42255-019-0073-4"},{"key":"e_1_2_12_304_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-020-63397-7"},{"key":"e_1_2_12_305_2","doi-asserted-by":"publisher","DOI":"10.1038\/srep46208"},{"key":"e_1_2_12_306_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2013.07.030"},{"key":"e_1_2_12_307_2","doi-asserted-by":"publisher","DOI":"10.1111\/bph.15083"},{"key":"e_1_2_12_308_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bcp.2019.113643"},{"key":"e_1_2_12_309_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2019.172715"},{"key":"e_1_2_12_310_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.redox.2019.101120"},{"key":"e_1_2_12_311_2","doi-asserted-by":"publisher","DOI":"10.1002\/mnfr.201800164"},{"key":"e_1_2_12_312_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajpgi.00108.2015"}],"container-title":["Oxidative Medicine and Cellular Longevity"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/omcl\/2021\/6611126.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/omcl\/2021\/6611126.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1155\/2021\/6611126","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,8,7]],"date-time":"2024-08-07T18:50:28Z","timestamp":1723056628000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1155\/2021\/6611126"}},"subtitle":[],"editor":[{"given":"Miguel","family":"S\u00e1nchez \u00c1lvarez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2021,1]]},"references-count":312,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2021,1]]}},"alternative-id":["10.1155\/2021\/6611126"],"URL":"https:\/\/doi.org\/10.1155\/2021\/6611126","archive":["Portico"],"relation":{},"ISSN":["1942-0900","1942-0994"],"issn-type":[{"value":"1942-0900","type":"print"},{"value":"1942-0994","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,1]]},"assertion":[{"value":"2020-10-09","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-01-23","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-02-10","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"6611126"}}