{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,4]],"date-time":"2025-12-04T17:10:33Z","timestamp":1764868233962,"version":"3.46.0"},"reference-count":18,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2021,1,11]],"date-time":"2021-01-11T00:00:00Z","timestamp":1610323200000},"content-version":"vor","delay-in-days":10,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Case Reports in Pediatrics"],"published-print":{"date-parts":[[2021,1]]},"abstract":"<jats:p>\n                    Li\u2013Fraumeni syndrome is an inherited, autosomal dominant disease. It is categorized as a rare disease caused by mutations of the\n                    <jats:italic>TP53<\/jats:italic>\n                    gene, which causes increased susceptibility of the patients and their children to many types of cancer. Choroid plexus tumor is rare, which occurs in 0.3 cases per 1,000,000 people, of which 40% turn out to be carcinomas. We present a 12\u2010year\u2010old boy with a history of worsening headaches of more than one month, gait disturbance, projectile vomiting, and right hemiparesis. An intraventricular tumor was identified in the occipital of the left lateral ventricle, which turned out to be a TP53\u2010mutant choroidal plexus carcinoma.\n                  <\/jats:p>","DOI":"10.1155\/2021\/6612802","type":"journal-article","created":{"date-parts":[[2021,1,12]],"date-time":"2021-01-12T17:46:54Z","timestamp":1610473614000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Pediatric Case of Li\u2013Fraumeni Syndrome in Honduras"],"prefix":"10.1155","volume":"2021","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4880-3569","authenticated-orcid":false,"given":"R.","family":"Mart\u00ednez-Beckerat","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4183-9104","authenticated-orcid":false,"given":"C.","family":"Alas-Pineda","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5058-3564","authenticated-orcid":false,"given":"M.","family":"Melgar-Gonzales","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1903-9680","authenticated-orcid":false,"given":"B.","family":"Mej\u00eda-Raudales","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4786-0123","authenticated-orcid":false,"given":"N.","family":"Andino-Paz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2894-1342","authenticated-orcid":false,"given":"S.","family":"Bejarano-C\u00e1ceres","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3623-8996","authenticated-orcid":false,"given":"J.","family":"Chiang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2021,1,11]]},"reference":[{"key":"e_1_2_7_1_2","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-71-4-747"},{"key":"e_1_2_7_2_2","doi-asserted-by":"publisher","DOI":"10.4067\/S0717-75262014000300006"},{"key":"e_1_2_7_3_2","doi-asserted-by":"publisher","DOI":"10.1002\/humu.23673"},{"key":"e_1_2_7_4_2","article-title":"Li-fraumeni syndrome","author":"Schneider K.","year":"2019","journal-title":"GeneReviews (\u00ae)"},{"key":"e_1_2_7_5_2","article-title":"An\u00e1lisis cl\u00ednico de un caso y revisi\u00f3n de la literatura","volume":"3","author":"Fraumeni S. d. L.","year":"2018","journal-title":"Revista Uruguaya de Medicina Interna"},{"key":"e_1_2_7_6_2","doi-asserted-by":"publisher","DOI":"10.7705\/biomedica.v36i3.2793"},{"key":"e_1_2_7_7_2","first-page":"27","article-title":"Mutaciones en TP53\u202f: una breve revisi\u00f3n","volume":"1","author":"Murillo A.","year":"2016","journal-title":"Revista Peruana de Divulgaci\u00f3n Cient\u00ed ica en Gen\u00e9tica y Biolog\u00eda Molecular"},{"key":"e_1_2_7_8_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF03167075"},{"key":"e_1_2_7_9_2","first-page":"20","article-title":"An\u00e1lisis cl\u00ednico de un caso y revisi\u00f3n de la literatura","volume":"3","author":"Camejo N.","year":"2018","journal-title":"Revista Uruguaya de Medicina Interna"},{"key":"e_1_2_7_10_2","first-page":"109","article-title":"Papiloma del plexo coroide calcificado extenso y osificado en la superficie temporal media como causa de epilepsia","volume":"3","author":"Tena-Suck M. L.","year":"2019","journal-title":"Revista M\u00e9dica Cl\u00ednica"},{"key":"e_1_2_7_11_2","first-page":"191","article-title":"Carcinoma de plexos coroides del III ventr\u00edculo en paciente adulto","volume":"8","author":"Reyes-Velasco E.","year":"2017","journal-title":"Revista M\u00e9dica Cl\u00ednica"},{"key":"e_1_2_7_12_2","unstructured":"St. Jude Children\u2019s Research Hospital Tumor de Plexo Coroideo 2018 https:\/\/together.stjude.org\/es-us\/acerca-del-c%C3%A1ncer-pedi%C3%A1trico\/tipos\/tumores-cerebro-m%C3%A9dula-espinal\/tumor-de-plexo-coroideo.html."},{"key":"e_1_2_7_13_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00401-007-0243-4"},{"key":"e_1_2_7_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejca.2005.01.026"},{"key":"e_1_2_7_15_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.onc.1204583"},{"key":"e_1_2_7_16_2","doi-asserted-by":"publisher","DOI":"10.1002\/mpo.2950250603"},{"key":"e_1_2_7_17_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11060-007-9428-x"},{"key":"e_1_2_7_18_2","doi-asserted-by":"publisher","DOI":"10.4103\/1817-1745.97633"}],"container-title":["Case Reports in Pediatrics"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/cripe\/2021\/6612802.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/cripe\/2021\/6612802.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1155\/2021\/6612802","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,4]],"date-time":"2025-12-04T17:06:10Z","timestamp":1764867970000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1155\/2021\/6612802"}},"subtitle":[],"editor":[{"given":"Juan","family":"Mej\u00eda-Arangur\u00e9","sequence":"additional","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2021,1]]},"references-count":18,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2021,1]]}},"alternative-id":["10.1155\/2021\/6612802"],"URL":"https:\/\/doi.org\/10.1155\/2021\/6612802","archive":["Portico"],"relation":{},"ISSN":["2090-6803","2090-6811"],"issn-type":[{"type":"print","value":"2090-6803"},{"type":"electronic","value":"2090-6811"}],"subject":[],"published":{"date-parts":[[2021,1]]},"assertion":[{"value":"2020-10-17","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-12-28","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-01-11","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"6612802"}}