{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,31]],"date-time":"2026-01-31T05:20:30Z","timestamp":1769836830533,"version":"3.49.0"},"reference-count":22,"publisher":"Wiley","license":[{"start":{"date-parts":[[2021,5,30]],"date-time":"2021-05-30T00:00:00Z","timestamp":1622332800000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Evidence-Based Complementary and Alternative Medicine"],"published-print":{"date-parts":[[2021,5,30]]},"abstract":"<jats:p>Ficus palmata is rich in several phytochemicals such as chromone, isoflavones, terpenes, lignans, coumarins, glycosides, and furanocoumarins and have been traditionally used for the management of different gastrointestinal disorders. This research reveals the effects of Ficus palmata fruit extracts\u2014Ficus palmata chloroform (Fp.CHCl3) and Ficus palmata aqueous (Fp.Aq)\u2014on gut activity through in vivo and in vitro analyses. Antidiarrheal and enteropooling assays were analyzed with castor oil-induced diarrhea and intestinal fluid accumulation. Jejunum tissues of rabbits were isolated (antispasmodic) for in vitro experiments. Antimotility was carried out by charcoal meal for determining transient time, and ethanol-induced ulcer assay was used to measure the ulceration of stomach; molecular pathways were assessed through proteomic approach. Fp.CHCl3 and Fp.Aq extracts attributed dose-dependently protection against diarrhea, and intestinal fluid secretions were inhibited dose dependently. Extracts of Fp.CHCl3 and Fp.Aq produced reduction in spontaneous and K+ (at 80\u2009Mm)-induced contractions in isolated jejunum tissues, along with the decreased length covered by charcoal in charcoal meal transient time activity. The extract exhibited gastroprotective outcome in rats and reduced tumor necrotic factor (TNF-\u03b1) levels and IL-18, measured by proteomic approach. Morphological studies\u2019 results showed that ethanol induced significant gastritis, apoptosis, swelling of mucosa, and hydropic degeneration leading to cellular degeneration and necrosis, observed through staining techniques. Furthermore, ethanol activated the inflammation pathway in all gastric zones by elevating the levels of cyclooxygenase-2, TNF-\u03b1, and nuclear factor kappa light-chain enhancer of activated B-cells. Overall results expressed the antidiarrheal, antispasmodic, enteropooling, antimotility, and antiulcer activities of Ficus palmata fruit extract.<\/jats:p>","DOI":"10.1155\/2021\/6613140","type":"journal-article","created":{"date-parts":[[2021,6,1]],"date-time":"2021-06-01T03:34:12Z","timestamp":1622518452000},"page":"1-11","source":"Crossref","is-referenced-by-count":12,"title":["Proteomic Analysis and In Vivo Studies Reveal the Potential Gastroprotective Effects of CHCl3 and Aqueous Extracts of Ficus palmata"],"prefix":"10.1155","volume":"2021","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1126-6317","authenticated-orcid":true,"given":"Sameen Fatima","family":"Ansari","sequence":"first","affiliation":[{"name":"Riphah Institute of Pharmaceutical Sciences, Riphah International University, Islamabad, Pakistan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9627-2726","authenticated-orcid":true,"given":"Arif-ullah","family":"Khan","sequence":"additional","affiliation":[{"name":"Riphah Institute of Pharmaceutical Sciences, Riphah International University, Islamabad, Pakistan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2639-0997","authenticated-orcid":true,"given":"Neelum Gul","family":"Qazi","sequence":"additional","affiliation":[{"name":"Riphah Institute of Pharmaceutical Sciences, Riphah International University, Islamabad, Pakistan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5415-2179","authenticated-orcid":true,"given":"Fawad Ali","family":"Shah","sequence":"additional","affiliation":[{"name":"Riphah Institute of Pharmaceutical Sciences, Riphah International University, Islamabad, Pakistan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8913-6825","authenticated-orcid":true,"given":"Komal","family":"Naeem","sequence":"additional","affiliation":[{"name":"Riphah Institute of Pharmaceutical Sciences, Riphah International University, Islamabad, Pakistan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","reference":[{"issue":"2","key":"1","first-page":"1","article-title":"Wild edible plants of Sewa catchment area in Northwest Himalaya","volume":"1","author":"M. Khan","year":"2009","journal-title":"Journal of Plant Development Science"},{"key":"2","volume-title":"Wildlife Values and Management in Northern Sudan","author":"M. B. Nimir","year":"1983"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.1641\/0006-3568(2005)055[1053:fatdot]2.0.co;2"},{"issue":"4","key":"4","doi-asserted-by":"crossref","first-page":"1","DOI":"10.4172\/2161-1009.1000144","article-title":"Phytochemical analysis of medicinal plants occurring in local area of Mardan","volume":"2","author":"A. Wadood","year":"2013","journal-title":"Biochem Anal Biochem"},{"key":"5","doi-asserted-by":"publisher","DOI":"10.1155\/2014\/762620"},{"key":"6","doi-asserted-by":"crossref","first-page":"374","DOI":"10.31254\/phyto.2014.3511","article-title":"A review on Ficus palmata (wild himalayan fig)","volume":"3","author":"Y. Joshi","year":"2014","journal-title":"Phytopharmacol"},{"key":"7","doi-asserted-by":"publisher","DOI":"10.1016\/j.jsps.2013.12.010"},{"issue":"7","key":"8","first-page":"1072","article-title":"Indigenous knowledge and folk use of medicinal plants by the tribal communities of Hazar Nao Forest, Malakand District, North Pakistan","volume":"5","author":"W. Murad","year":"2011","journal-title":"Journal of Medicinal Plants Research"},{"key":"9","doi-asserted-by":"publisher","DOI":"10.1155\/2019\/4921086"},{"key":"10","doi-asserted-by":"publisher","DOI":"10.4314\/tjpr.v6i1.14644"},{"key":"11","doi-asserted-by":"publisher","DOI":"10.1186\/s12906-017-1625-3"},{"key":"12","doi-asserted-by":"publisher","DOI":"10.1002\/ptr.3642"},{"key":"13","doi-asserted-by":"publisher","DOI":"10.1002\/ptr.1414"},{"key":"14","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2018.01037"},{"key":"15","doi-asserted-by":"publisher","DOI":"10.1186\/s13065-017-0314-0"},{"key":"16","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2016.10.016"},{"key":"17","doi-asserted-by":"publisher","DOI":"10.3389\/fnins.2018.00888"},{"issue":"3","key":"18","first-page":"124","article-title":"Acute toxicity effects of the methanolic extract of Fagara zanthoxyloides (Lam.) root-bark","volume":"3","author":"J. W. Ogwal-Okeng","year":"2003","journal-title":"African Health Sciences"},{"key":"19","doi-asserted-by":"publisher","DOI":"10.2174\/1389200219666180404094147"},{"key":"20","doi-asserted-by":"publisher","DOI":"10.1016\/j.taap.2013.05.035"},{"key":"21","doi-asserted-by":"publisher","DOI":"10.1080\/13880200902960206"},{"key":"22","doi-asserted-by":"publisher","DOI":"10.1002\/9781119431077.ch4"}],"container-title":["Evidence-Based Complementary and Alternative Medicine"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/ecam\/2021\/6613140.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/ecam\/2021\/6613140.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/ecam\/2021\/6613140.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,12,29]],"date-time":"2022-12-29T06:31:38Z","timestamp":1672295498000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.hindawi.com\/journals\/ecam\/2021\/6613140\/"}},"subtitle":[],"editor":[{"given":"Roberta","family":"Bernardini","sequence":"additional","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2021,5,30]]},"references-count":22,"alternative-id":["6613140","6613140"],"URL":"https:\/\/doi.org\/10.1155\/2021\/6613140","relation":{},"ISSN":["1741-4288","1741-427X"],"issn-type":[{"value":"1741-4288","type":"electronic"},{"value":"1741-427X","type":"print"}],"subject":[],"published":{"date-parts":[[2021,5,30]]}}}