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However, due to the lack of permeability of the blood\u2010brain barrier (BBB) as well as the brief half\u2010life in serum, clinical application is not widespread. To study the participation of exosomes containing BDNF in I\/R, we isolated exosomes from BDNF\u2010overexpressing HEK293. The protective outcomes of exosomes in hypoxia\/reoxygenation (H\/R) experiments were determined by the use of SY\u20105Y cells. Exosome\u2010BDNF therapy restrained H\/R\u2010induced apoptosis by inhibition of the reducing levels of oxidative stress and calcium ions in the cells while maintaining stable levels of mitochondrial membrane potential in brain cells damaged by I\/R. We then constructed a cerebral I\/R injury model using SD rats to find the function of BDNF in exosome\u2010mediated neuroprotection. The in vivo experiments conducted established that exosomes from BDNF\u2010overexpressing HEK293 cells improved cerebral I\/R injury by concealing neuronal apoptosis. 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