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The peptide receptor radionuclide therapy (PRRT) is a treatment option for patients with disseminated, inoperable G1 and G2 neuroendocrine tumours (NETs). The study aims to evaluate the safety, efficacy, and progression-free survival (PFS) of patients after retreatment (R-PRRT) and re-retreatment (RR-PRRT) with tandem isotopes [90Y]Y\/[177Lu]Lu-DOTATATE. Material and Methods. Out of 99 treated patients with G1 and G2 NETs, 26 were included in the study and treated with the repeated PRRT (with 5 undergoing the re-repeated PRRT treatment) after an initial positive response to four PRRT cycles and later progression of the disease. [68Ga]Ga-DOTATATE PET\/CT and CT\/MRI procedures were performed before and after the treatment. Patients were treated with [90Y]Y\/[177Lu]Lu-DOTATATE (1\u2009:\u20091) with mixed amino acid infusion for kidney protection. Toxicity was evaluated using the CTCAE 3.0 criteria. Results. The median follow-up was 88 months (the range: 42\u2013164). The median cumulative administered activity was 22.2\u2009GBq (the range: 17.8\u201330.7\u2009GBq). Myelodysplastic syndrome occurred in one patient (3.8%), and grade 4 renal toxicity was also detected in one patient (3.8%). No other cases of grade 3 or 4 bone marrow and renal toxicity were observed. The median PFS rate was 31 months after the PRRT and 23 months following the R-PRRT. The OS rate from the diagnosis (OS-d) was 109 months and from the start of the PRRT (OS-t)-92.4 months. During the restaging, 3\u20136 months after the PRRT, PR, SD, and PD were observed in 19.2%, 80.8%, and 0% of the patients, respectively. After the R-PRRT, PR, SD, and PD were observed in 50%, 42.3%, and 7.7% of the patients, respectively. Conclusions. The repeated therapy with [90Y]Y\/[177Lu]Lu-DOTATATE is safe and effective for patients with disseminated, inoperable G1 and G2 neuroendocrine tumours.<\/jats:p>","DOI":"10.1155\/2021\/6615511","type":"journal-article","created":{"date-parts":[[2021,1,24]],"date-time":"2021-01-24T02:05:10Z","timestamp":1611453910000},"page":"1-10","source":"Crossref","is-referenced-by-count":20,"title":["The Safety and Efficacy of the Repeated PRRT with [90Y]Y\/[177Lu]Lu-DOTATATE in Patients with NET"],"prefix":"10.1155","volume":"2021","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6314-2661","authenticated-orcid":true,"given":"Anna","family":"Zemczak","sequence":"first","affiliation":[{"name":"Department of Endocrinology and Neuroendocrine Tumours, Department of Pathophysiology and Endocrinology, Medical University of Silesia, Katowice, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1661-175X","authenticated-orcid":true,"given":"Pawe\u0142","family":"Gut","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, Metabolism and Internal Diseases, Poznan University of Medical Sciences, Poznan, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0358-0915","authenticated-orcid":true,"given":"Dariusz","family":"Pawlak","sequence":"additional","affiliation":[{"name":"Radioisotope Centre POLATOM, National Centre for Nuclear Research, Otwock, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1943-264X","authenticated-orcid":true,"given":"Maciej","family":"Ko\u0142odziej","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Radioisotope Therapy, Military Institute of Medicine, Warsaw, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7117-9621","authenticated-orcid":true,"given":"Leszek","family":"Kr\u00f3licki","sequence":"additional","affiliation":[{"name":"Nuclear Medicine Department, Medical University of Warsaw, Warsaw, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3755-1722","authenticated-orcid":true,"given":"Beata","family":"Kos-Kud\u0142a","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Neuroendocrine Tumours, Department of Pathophysiology and Endocrinology, Medical University of Silesia, Katowice, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6296-7220","authenticated-orcid":true,"given":"Marek","family":"Rucha\u0142a","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, Metabolism and Internal Diseases, Poznan University of Medical Sciences, Poznan, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2357-0634","authenticated-orcid":true,"given":"Grzegorz","family":"Kami\u0144ski","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Radioisotope Therapy, Military Institute of Medicine, Warsaw, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7434-6720","authenticated-orcid":true,"given":"Jolanta","family":"Kunikowska","sequence":"additional","affiliation":[{"name":"Nuclear Medicine Department, Medical University of Warsaw, Warsaw, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","reference":[{"issue":"1","key":"1","first-page":"92","article-title":"Individualized peptide-related-radionuclide-therapy concept using different radiolabelled somatostatin analogs in advanced cancer patients","volume":"54","author":"M. 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