{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T05:12:56Z","timestamp":1783487576758,"version":"3.55.0"},"reference-count":46,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2021,3,27]],"date-time":"2021-03-27T00:00:00Z","timestamp":1616803200000},"content-version":"vor","delay-in-days":85,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Oxidative Medicine and Cellular Longevity"],"published-print":{"date-parts":[[2021,1]]},"abstract":"<jats:p>SARS\u2010CoV\u20102 virus causes infection which led to a global pandemic in 2020 with the development of severe acute respiratory syndrome. Therefore, this study was aimed at examining its possible role in predicting severity and intrahospital mortality of COVID\u201019, alongside with other laboratory and biochemical procedures, clinical signs, symptoms, and comorbidity. This study, approved by the Ethical Committee of Clinical Center Kragujevac, was designed as an observational prospective cross\u2010sectional clinical study which was conducted on 127 patients with diagnosed respiratory COVID\u201019 viral infection from April to August 2020. The primary goals were to determine the predictors of COVID\u201019 severity and to determine the predictors of the negative outcome of COVID\u201019 infection. All patients were divided into three categories: patients with a mild form, moderate form, and severe form of COVID\u201019 infection. All biochemical and laboratory procedures were done on the first day of the hospital admission. Respiratory (<jats:italic>p<\/jats:italic> &lt; 0.001) and heart (<jats:italic>p<\/jats:italic> = 0.002) rates at admission were significantly higher in patients with a severe form of COVID\u201019. From all observed hematological and inflammatory markers, only white blood cell count (9.43 \u00b1 4.62, <jats:italic>p<\/jats:italic> = 0.001) and LDH (643.13 \u00b1 313.3, <jats:italic>p<\/jats:italic> = 0.002) were significantly higher in the severe COVID\u201019 group. We have observed that in the severe form of SARS\u2010CoV\u20102, the levels of superoxide anion radicals were substantially higher than those in two other groups (11.3 \u00b1 5.66, <jats:italic>p<\/jats:italic> &lt; 0.001) and the nitric oxide level was significantly lower in patients with the severe disease (2.66 \u00b1 0.45, <jats:italic>p<\/jats:italic> &lt; 0.001). Using a linear regression model, TA, anosmia, ageusia, O<jats:sub>2<\/jats:sub><jats:sup>\u2212<\/jats:sup>, and the duration at the ICU are estimated as predictors of severity of SARS\u2010CoV\u20102 disease. The presence of dyspnea and a higher heart rate were confirmed as predictors of a negative, fatal outcome. Results from our study show that presence of hypertension, anosmia, and ageusia, as well as the duration of ICU stay, and serum levels of O<jats:sub>2<\/jats:sub><jats:sup>\u2212<\/jats:sup> are predictors of COVID\u201019 severity, while the presence of dyspnea and an increased heart rate on admission were predictors of COVID\u201019 mortality.<\/jats:p>","DOI":"10.1155\/2021\/6615787","type":"journal-article","created":{"date-parts":[[2021,3,27]],"date-time":"2021-03-27T18:20:08Z","timestamp":1616869208000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":34,"title":["Predicting Severity and Intrahospital Mortality in COVID\u201019: The Place and Role of Oxidative Stress"],"prefix":"10.1155","volume":"2021","author":[{"given":"Ivan","family":"Cekerevac","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tamara 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