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This study is aimed at detecting the presence of <jats:italic>H<\/jats:italic>. <jats:italic>pylori<\/jats:italic> and identifying the CagA tyrosine phosphorylation motifs in Ghanaian patients. <jats:italic>Material and Methods<\/jats:italic>. A total of 94 archival genomic DNA samples from gastric biopsies were used for the study, and <jats:italic>H<\/jats:italic>. <jats:italic>pylori<\/jats:italic> was detected by amplifying the 16S rRNA gene. The 3\u2009<jats:sup>\u2032<\/jats:sup>\u2010end variable region of the cagA gene was amplified, and the entire 3\u2009<jats:sup>\u2032<\/jats:sup>\u2010end was sequenced and translated into amino acids. <jats:italic>Results<\/jats:italic>. <jats:italic>H<\/jats:italic>. <jats:italic>pylori<\/jats:italic> was detected in 53.2% (50\/94) of the samples, and all the detected bacteria harboured the <jats:italic>cagA<\/jats:italic> gene. Two variants of the bacteria were identified based on the size of the amplified <jats:italic>cagA<\/jats:italic> gene: 207\u2009bp and 285\u2009bp. The 207\u2009bp and 285\u2009bp variants accounted for 74% and 22%, respectively, and 4% showed both fragments. Translated amino acid sequence of the <jats:italic>cagA<\/jats:italic> gene showed EPIYA\u2010A, EPIYA\u2010B, and EPIYA\u2010C (ABC type) motifs, indicating the Western variant. The CagA protein C\u2010terminal showed insertion of amino acids in the sequence flanking the EPIYA\u2010A motif at the N\u2010terminal and a complete deletion of the EPIYA\u2010CC and EPIYA\u2010CCC motifs together with the flanking sequences. <jats:italic>Conclusions<\/jats:italic>. <jats:italic>H<\/jats:italic>. <jats:italic>pylori<\/jats:italic> identified were Western variant (ABC type) with unique amino acid insertions, suggesting unique variants in Ghanaian patients. Further investigation is however required to understand the role of the molecular diversity of the variant in gastric disease outcome.<\/jats:p>","DOI":"10.1155\/2021\/6616059","type":"journal-article","created":{"date-parts":[[2021,3,31]],"date-time":"2021-03-31T18:20:15Z","timestamp":1617214815000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Helicobacter Pylori Variants with ABC\u2010Type Tyrosine Phosphorylation Motif in Gastric Biopsies of Ghanaian Patients"],"prefix":"10.1155","volume":"2021","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7179-1872","authenticated-orcid":false,"given":"Emmanuel A.","family":"Tagoe","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8793-3641","authenticated-orcid":false,"given":"Gordon A.","family":"Awandare","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0621-876X","authenticated-orcid":false,"given":"Osbourne","family":"Quaye","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2704-2422","authenticated-orcid":false,"given":"Richard H.","family":"Asmah","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9347-0516","authenticated-orcid":false,"given":"Timothy N.","family":"Archampong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mahasin A.","family":"Osman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7050-2634","authenticated-orcid":false,"given":"Charles A.","family":"Brown","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2021,3,31]]},"reference":[{"doi-asserted-by":"publisher","key":"e_1_2_10_1_2","DOI":"10.1053\/j.gastro.2017.04.022"},{"doi-asserted-by":"publisher","key":"e_1_2_10_2_2","DOI":"10.11604\/pamj.2015.20.178.5024"},{"doi-asserted-by":"publisher","key":"e_1_2_10_3_2","DOI":"10.3390\/toxins10040163"},{"doi-asserted-by":"publisher","key":"e_1_2_10_4_2","DOI":"10.3389\/fcimb.2012.00092"},{"doi-asserted-by":"publisher","key":"e_1_2_10_5_2","DOI":"10.1128\/JB.00063-10"},{"doi-asserted-by":"publisher","key":"e_1_2_10_6_2","DOI":"10.1002\/ijc.21831"},{"doi-asserted-by":"publisher","key":"e_1_2_10_7_2","DOI":"10.1128\/mBio.02001-15"},{"doi-asserted-by":"publisher","key":"e_1_2_10_8_2","DOI":"10.3389\/fimmu.2013.00328"},{"doi-asserted-by":"publisher","key":"e_1_2_10_9_2","DOI":"10.1093\/femspd\/ftu021"},{"doi-asserted-by":"publisher","key":"e_1_2_10_10_2","DOI":"10.1186\/s12876-014-0223-9"},{"doi-asserted-by":"publisher","key":"e_1_2_10_11_2","DOI":"10.1111\/j.1349-7006.2005.00130.x"},{"doi-asserted-by":"publisher","key":"e_1_2_10_12_2","DOI":"10.1097\/MD.0000000000006620"},{"doi-asserted-by":"publisher","key":"e_1_2_10_13_2","DOI":"10.1007\/s10120-009-0507-x"},{"doi-asserted-by":"publisher","key":"e_1_2_10_14_2","DOI":"10.1074\/jbc.M503583200"},{"doi-asserted-by":"publisher","key":"e_1_2_10_15_2","DOI":"10.1038\/srep15749"},{"doi-asserted-by":"publisher","key":"e_1_2_10_16_2","DOI":"10.1016\/j.celrep.2017.08.080"},{"doi-asserted-by":"publisher","key":"e_1_2_10_17_2","DOI":"10.1111\/j.1469-0691.2009.02811.x"},{"doi-asserted-by":"crossref","unstructured":"HusseinN. 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