{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,28]],"date-time":"2025-10-28T05:55:44Z","timestamp":1761630944166,"version":"3.40.5"},"reference-count":26,"publisher":"Wiley","license":[{"start":{"date-parts":[[2021,3,20]],"date-time":"2021-03-20T00:00:00Z","timestamp":1616198400000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Gastroenterology Research and Practice"],"published-print":{"date-parts":[[2021,3,20]]},"abstract":"<jats:p>Background. EndoFaster\u00ae analyzes gastric juice in real time during gastroscopy allowing the detection of hypo-achlorhydric conditions, like corpus atrophic gastritis. Narrow-band imaging (NBI) endoscopy allows to accurately detect and perform target biopsies in areas of intestinal metaplasia, a histological change often associated to corpus atrophic gastritis. Aims. To compare the diagnostic accuracy of EndoFaster\u00ae with histological evaluation for corpus atrophic gastritis through high-resolution (HR) NBI targeted biopsies. Methods. Prospective study on consecutive adult patients undergoing gastroscopy between April and November 2018. Patients in therapy with proton pump inhibitors, previous gastric surgery, and\/or known gastric neoplasia were excluded. At the beginning of gastroscopy, gastric juice was aspirated and analyzed by EndoFaster\u00ae in 15 seconds. Endoscopists were blinded to the report of EndoFaster\u00ae. Evaluation of gastric mucosa in HR-white light was firstly performed, then with HR-NBI allowing to perform targeted biopsies on areas suspected for intestinal metaplasia; otherwise, biopsies were performed according to the updated Sydney System protocol and sent for histopathological evaluation. Results. Overall, 124 patients were included [64% F; 56 (18-85) years]. Corpus atrophic gastritis was present in 41.9% of patients. EndoFaster\u00ae showed an accuracy for corpus atrophic gastritis diagnosis, compared to histopathological evaluation as gold standard, of 87.1% and a sensitivity, specificity, PPV, and NPV of 78.8%, 93.1%, 89.1%, and 85.9%, respectively. pH showed a positive correlation with the severity score of atrophy (<jats:inline-formula>\n                     <a:math xmlns:a=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M1\">\n                        <a:mi>r<\/a:mi>\n                        <a:mo>=<\/a:mo>\n                        <a:mn>0.67<\/a:mn>\n                     <\/a:math>\n                  <\/jats:inline-formula>, 95% CI: 0.73-0.81, and <jats:inline-formula>\n                     <c:math xmlns:c=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M2\">\n                        <c:mi>p<\/c:mi>\n                        <c:mo>&lt;<\/c:mo>\n                        <c:mn>0.0001<\/c:mn>\n                     <\/c:math>\n                  <\/jats:inline-formula>). EndoFaster\u00ae allowed to diagnose corpus atrophic gastritis in 3.7% of patients negative to NBI (corpus atrophic gastritis without intestinal metaplasia). Conclusion. EndoFaster\u00ae seems a promising tool to diagnose corpus atrophic gastritis. The evaluation of hypo-achlorhydria during gastroscopy can address bioptic sampling in corpus atrophic gastritis patients without intestinal metaplasia.<\/jats:p>","DOI":"10.1155\/2021\/6616334","type":"journal-article","created":{"date-parts":[[2021,3,22]],"date-time":"2021-03-22T19:50:08Z","timestamp":1616442608000},"page":"1-8","source":"Crossref","is-referenced-by-count":9,"title":["Diagnostic Accuracy of EndoFaster\u00ae and Narrow-Band Imaging Endoscopy in Patients with Impaired Gastric Acid Secretion: A Real-Time Prospective Study"],"prefix":"10.1155","volume":"2021","author":[{"given":"M.","family":"Cazzato","sequence":"first","affiliation":[{"name":"Department of Medical-Surgical Sciences and Translational Medicine, Sant\u2019Andrea Hospital, Sapienza University of Rome, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G.","family":"Esposito","sequence":"additional","affiliation":[{"name":"Department of Medical-Surgical Sciences and Translational Medicine, Sant\u2019Andrea Hospital, Sapienza University of Rome, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G.","family":"Galli","sequence":"additional","affiliation":[{"name":"Department of Medical-Surgical Sciences and Translational Medicine, Sant\u2019Andrea Hospital, Sapienza University of Rome, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E.","family":"Pilozzi","sequence":"additional","affiliation":[{"name":"Department of Pathology, Sant\u2019Andrea Hospital, Sapienza University of Rome, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E.","family":"Lahner","sequence":"additional","affiliation":[{"name":"Department of Medical-Surgical Sciences and Translational Medicine, Sant\u2019Andrea Hospital, Sapienza University of Rome, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"V. D.","family":"Corleto","sequence":"additional","affiliation":[{"name":"Department of Medical-Surgical Sciences and Translational Medicine, Sant\u2019Andrea Hospital, Sapienza University of Rome, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Zullo","sequence":"additional","affiliation":[{"name":"Gastroenterology and Digestive Endoscopy, \u201cNuovo Regina Margherita\u201d Hospital, Rome, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E.","family":"Di Giulio","sequence":"additional","affiliation":[{"name":"Department of Medical-Surgical Sciences and Translational Medicine, Sant\u2019Andrea Hospital, Sapienza University of Rome, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9120-5957","authenticated-orcid":true,"given":"B.","family":"Annibale","sequence":"additional","affiliation":[{"name":"Department of Medical-Surgical Sciences and Translational Medicine, Sant\u2019Andrea Hospital, Sapienza University of Rome, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.1055\/a-0859-1883"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.3322\/caac.20107"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2036.2002.01301.x"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.1016\/j.dld.2019.09.016"},{"key":"5","doi-asserted-by":"publisher","DOI":"10.1016\/S0016-5085(97)70075-1"},{"key":"6","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2036.2001.01101.x"},{"key":"7","doi-asserted-by":"publisher","DOI":"10.1038\/nrgastro.2013.101"},{"key":"8","doi-asserted-by":"publisher","DOI":"10.1111\/apha.12208"},{"key":"9","doi-asserted-by":"publisher","DOI":"10.1097\/00000478-199610000-00001"},{"key":"10","doi-asserted-by":"publisher","DOI":"10.1159\/000487470"},{"key":"11","doi-asserted-by":"publisher","DOI":"10.1055\/s-0042-108435"},{"key":"12","doi-asserted-by":"publisher","DOI":"10.1055\/a-0808-3186"},{"key":"13","doi-asserted-by":"publisher","DOI":"10.1111\/hel.12149"},{"key":"14","doi-asserted-by":"publisher","DOI":"10.5009\/gnl17063"},{"key":"15","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v16.i43.5496"},{"key":"16","doi-asserted-by":"publisher","DOI":"10.1016\/j.gie.2007.03.1052"},{"key":"17","doi-asserted-by":"publisher","DOI":"10.1055\/s-2005-870373"},{"key":"18","doi-asserted-by":"publisher","DOI":"10.1177\/2050640615610021"},{"key":"19","doi-asserted-by":"publisher","DOI":"10.1016\/j.dld.2014.03.008"},{"key":"20","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen-2016-012799"},{"key":"21","doi-asserted-by":"publisher","DOI":"10.3109\/00365521.2015.1010570"},{"key":"22","doi-asserted-by":"publisher","DOI":"10.1097\/MEG.0000000000001246"},{"key":"23","doi-asserted-by":"publisher","DOI":"10.1258\/0969141041732184"},{"key":"24","doi-asserted-by":"publisher","DOI":"10.1111\/apt.14248"},{"key":"25","doi-asserted-by":"publisher","DOI":"10.1016\/j.gie.2017.03.1528"},{"key":"26","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2036.2006.02943.x"}],"container-title":["Gastroenterology Research and Practice"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/grp\/2021\/6616334.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/grp\/2021\/6616334.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/grp\/2021\/6616334.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,3,22]],"date-time":"2021-03-22T19:50:11Z","timestamp":1616442611000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.hindawi.com\/journals\/grp\/2021\/6616334\/"}},"subtitle":[],"editor":[{"given":"Jose Celso","family":"Ardengh","sequence":"additional","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2021,3,20]]},"references-count":26,"alternative-id":["6616334","6616334"],"URL":"https:\/\/doi.org\/10.1155\/2021\/6616334","relation":{},"ISSN":["1687-630X","1687-6121"],"issn-type":[{"type":"electronic","value":"1687-630X"},{"type":"print","value":"1687-6121"}],"subject":[],"published":{"date-parts":[[2021,3,20]]}}}