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A total of 64 pregnant Bama mini\u2010sows were randomly allocated into the control group (basal diet), antibiotic group (basal\u2009diet + 50\u2009g\/t virginiamycin), probiotic group (basal\u2009diet + 200\u2009mL\/d probiotics per pig), or synbiotic group (basal\u2009diet + 200\u2009mL\/d probiotics per pig + 500\u2009g\/t xylo\u2010oligosaccharides). On day 30 of post\u2010weaning, eight piglets per group with average body weight were selected for sample collection. The results showed that maternal probiotic supplementation increased the catalase (CAT) activity in plasma and glutathione peroxidase (GSH\u2010Px) and superoxide dismutase (SOD) activities in plasma, jejunum, and colon of piglets while decreased the malondialdehyde (MDA) and H<jats:sub>2<\/jats:sub>O<jats:sub>2<\/jats:sub> concentrations in plasma compared with the control group (<jats:italic>P<\/jats:italic> &lt; 0.05). Moreover, maternal synbiotic supplementation increased the plasma CAT activity, jejunal glutathione and GSH\u2010Px activities, jejunal and colonic total antioxidant capacity activity, and plasma and colonic SOD activity while decreased the colonic MDA concentration of offspring piglets compared with the control group (<jats:italic>P<\/jats:italic> &lt; 0.05). The mRNA levels of antioxidant enzyme\u2010related genes (copper\u2010 and zinc\u2010containing superoxide dismutase, nuclear factor erythroid 2\u2010related factor 1, and nuclear factor erythroid 2\u2010related factor 2) and mitochondrial\u2010related genes (adenosine triphosphate synthase alpha subunit, adenosine triphosphate synthase <jats:italic>\u03b2<\/jats:italic>, and mitochondrial transcription factor A) in the jejunal mucosa were significantly upregulated, while the level of colonic peroxisome proliferator\u2010activated receptor <jats:italic>\u03b3<\/jats:italic> coactivator\u20101<jats:italic>\u03b1<\/jats:italic> was downregulated by maternal synbiotic supplementation (<jats:italic>P<\/jats:italic> &lt; 0.05). Maternal probiotic supplementation increased (<jats:italic>P<\/jats:italic> &lt; 0.05) the <jats:italic>Bacteroidetes<\/jats:italic> abundance in the jejunum and <jats:italic>Bifidobacterium<\/jats:italic> abundance in the jejunum and colon, and synbiotic supplementation increased (<jats:italic>P<\/jats:italic> &lt; 0.05) the abundances of Firmicutes, <jats:italic>Bacteroidetes<\/jats:italic>, <jats:italic>Bifidobacterium<\/jats:italic>, and <jats:italic>Lactobacillus<\/jats:italic> in the jejunum of piglets. Furthermore, correlation analysis revealed that intestinal microbiota abundances were significantly correlated with antioxidant enzyme activities and mitochondrial\u2010related indexes. These findings indicated that maternal probiotic or synbiotic supplementation might be a promising strategy to improve the antioxidant capacity and mitochondrial function of offspring weaned piglets by altering the intestinal microbiota.<\/jats:p>","DOI":"10.1155\/2021\/6618874","type":"journal-article","created":{"date-parts":[[2021,5,5]],"date-time":"2021-05-05T18:06:43Z","timestamp":1620238003000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Maternal Probiotic or Synbiotic Supplementation Modulates Jejunal and Colonic Antioxidant Capacity, Mitochondrial Function, and Microbial Abundance in Bama Mini\u2010piglets"],"prefix":"10.1155","volume":"2021","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0371-348X","authenticated-orcid":false,"given":"Kai","family":"Wang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8034-6682","authenticated-orcid":false,"given":"Xiangfeng","family":"Kong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0118-5708","authenticated-orcid":false,"given":"Md. 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