{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,31]],"date-time":"2026-08-31T23:31:18Z","timestamp":1788219078919,"version":"build-2803163510"},"reference-count":18,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2021,2,25]],"date-time":"2021-02-25T00:00:00Z","timestamp":1614211200000},"content-version":"vor","delay-in-days":55,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Case Reports in Dentistry"],"published-print":{"date-parts":[[2021,1]]},"abstract":"<jats:p>Actinomycosis can be one of the causes of persistent periradicular lesions. This is the report of a patient who was first referred with complaint of pain in maxillary right incisors. A standard root canal therapy was carried out. Unluckily, the patient returned with recurrent symptoms; therefore, surgical endodontic retreatment was decided. While the large periradicular lesion was curetted, a whitish yellow granule\u2010like material came out from the periapical area that was submitted for histopathological examination. The apices of both maxillary right incisors were resected. Root\u2010end cavities were sealed with calcium\u2010enriched mixture (CEM) cement. Finally, the remaining large defect was filled with natural bone substitutes. Since the histopathological diagnosis revealed actinomycotic infection, oral penicillin V was prescribed for four weeks. At two\u2010year recall, the bone healing process was completed. Apical actinomycosis can cause therapy\u2010resistant lesions. Root\u2010end surgery employing CEM and bone substitutes might be an effective method to help bone healing in large periradicular lesions.<\/jats:p>","DOI":"10.1155\/2021\/6619731","type":"journal-article","created":{"date-parts":[[2021,2,25]],"date-time":"2021-02-25T21:50:05Z","timestamp":1614289805000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Grafting with Bone Substitute Materials in Therapy\u2010Resistant Periapical 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