{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,20]],"date-time":"2025-07-20T04:23:31Z","timestamp":1752985411179,"version":"3.37.3"},"reference-count":37,"publisher":"Wiley","license":[{"start":{"date-parts":[[2021,6,30]],"date-time":"2021-06-30T00:00:00Z","timestamp":1625011200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81974423","81902729","2019SK2031","2018Q01","2020M672517"],"award-info":[{"award-number":["81974423","81902729","2019SK2031","2018Q01","2020M672517"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Key Research and Development Program of Hunan Province","award":["81974423","81902729","2019SK2031","2018Q01","2020M672517"],"award-info":[{"award-number":["81974423","81902729","2019SK2031","2018Q01","2020M672517"]}]},{"name":"Xiangya Hospital Foundation for Young Scholars","award":["81974423","81902729","2019SK2031","2018Q01","2020M672517"],"award-info":[{"award-number":["81974423","81902729","2019SK2031","2018Q01","2020M672517"]}]},{"DOI":"10.13039\/501100002858","name":"China Postdoctoral Science Foundation","doi-asserted-by":"publisher","award":["81974423","81902729","2019SK2031","2018Q01","2020M672517"],"award-info":[{"award-number":["81974423","81902729","2019SK2031","2018Q01","2020M672517"]}],"id":[{"id":"10.13039\/501100002858","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["International Journal of Endocrinology"],"published-print":{"date-parts":[[2021,6,30]]},"abstract":"<jats:p>The health problems caused by the frequent relapse of papillary thyroid carcinoma (PTC) remain a worldwide concern since the morbidity rate of PTC ranks the highest among thyroid cancers. Residues from contralateral central lymph node metastases (con-CLNM) are the key reason for persistence or recurrence of unilateral papillary thyroid carcinoma (uni-PTC); however, the ability to assess the status of con-CLNM in uni-PTC patients is limited. To clarify the risk factors of con-CLNM, a total of 250 patients with uni-PTC who underwent total thyroidectomy and bilateral central lymph node dissection were recruited in this study. We compared the clinical, sonographic, and pathological characteristics of patients with con-CLNM to those without con-CLNM and established a nomogram for con-CLNM in uni-PTC. We found that male sex, without Hashimoto\u2019s thyroiditis, present capsular invasion, with ipsilateral lateral lymph node metastases, and the ratio of ipsilateral central lymph node metastases \u22650.16 were independent con-CLNM predictors of uni-PTC (ORs: 2.797, 0.430, 2.538, 2.202, and 26.588; 95% CIs: 1.182\u20136.617, 0.211\u20130.876, 1.223\u20135.267, 1.064\u20134.557, and 7.596\u201393.069, respectively). Additionally, a preoperative nomogram for the prediction of con-CLNM based on these risk factors showed good discrimination (C-index 0.881; 95% CI: 0.840\u20130.923; sensitivity 85.3%; specificity 76.0%) and good agreement via the calibration plot. Our study provided a way to quantitatively and accurately predict whether con-CLNM occurred in patients with uni-PTC, which may guide surgeons to evaluate the nodal status and perform tailored therapeutic central lymph node dissection.<\/jats:p>","DOI":"10.1155\/2021\/6621067","type":"journal-article","created":{"date-parts":[[2021,7,1]],"date-time":"2021-07-01T02:36:21Z","timestamp":1625106981000},"page":"1-10","source":"Crossref","is-referenced-by-count":6,"title":["A Prediction Model for Contralateral Central Neck Lymph Node Metastases in Unilateral Papillary Thyroid Cancer"],"prefix":"10.1155","volume":"2021","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3345-5277","authenticated-orcid":true,"given":"Hai-Long","family":"Tan","sequence":"first","affiliation":[{"name":"Department of General Surgery, Xiangya Hospital Central South University, Changsha 410008, Hunan, 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