{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,31]],"date-time":"2025-12-31T08:16:47Z","timestamp":1767169007608,"version":"build-2238731810"},"reference-count":39,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2021,1,28]],"date-time":"2021-01-28T00:00:00Z","timestamp":1611792000000},"content-version":"vor","delay-in-days":27,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100015640","name":"Tongji Hospital","doi-asserted-by":"publisher","award":["YXQN009"],"award-info":[{"award-number":["YXQN009"]}],"id":[{"id":"10.13039\/501100015640","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012226","name":"Fundamental Research Funds for the Central Universities","doi-asserted-by":"publisher","award":["2017KFYXJJ099"],"award-info":[{"award-number":["2017KFYXJJ099"]}],"id":[{"id":"10.13039\/501100012226","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003819","name":"Natural Science Foundation of Hubei Province","doi-asserted-by":"publisher","award":["2015CFB455"],"award-info":[{"award-number":["2015CFB455"]}],"id":[{"id":"10.13039\/501100003819","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82070396"],"award-info":[{"award-number":["82070396"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81570416"],"award-info":[{"award-number":["81570416"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81974032"],"award-info":[{"award-number":["81974032"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81570337"],"award-info":[{"award-number":["81570337"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Oxidative Medicine and Cellular Longevity"],"published-print":{"date-parts":[[2021,1]]},"abstract":"<jats:p>Pulmonary hypertension (PH) is a progressive and life\u2010threatening chronic disease in which increased pulmonary artery pressure (PAP) and pulmonary vasculature remodeling are prevalent. Inhaled nitric oxide (NO) has been used in newborns to decrease PAP in the clinic; however, the effects of NO endogenous derivatives, S\u2010nitrosothiols (SNO), on PH are still unknown. We have reported that S\u2010nitroso\u2010L\u2010cysteine (CSNO), one of the endogenous derivatives of NO, inhibited RhoA activity through oxidative nitrosation of its C16\/20 residues, which may be beneficial for both vasodilation and remodeling. In this study, we presented data to show that inhaled CSNO attenuated PAP in the monocrotaline\u2010 (MCT\u2010) induced PH rats and, moreover, improved right ventricular (RV) hypertrophy and fibrosis induced by RV overloaded pressure. In addition, aerosolized CSNO significantly inhibited the hyperactivation of signal transducers and activators of transduction 3 (STAT3) and extracellular regulated protein kinases (ERK) pathways in the lung of MCT\u2010induced rats. CSNO also regulated the expression of smooth muscle contractile protein and improved aberrant endoplasmic reticulum (ER) stress and mitophagy in lung tissues following MCT induction. On the other hand, CSNO inhibited reactive oxygen species (ROS) production in vitro, which is induced by angiotensin II (AngII) as well as interleukin 6 (IL\u20106). In addition, CSNO inhibited excessive ER stress and mitophagy induced by AngII and IL\u20106 in vitro; finally, STAT3 and ERK phosphorylation was inhibited by CSNO in a concentration\u2010dependent manner. Taken together, CSNO led to pulmonary artery relaxation and regulated pulmonary circulation remodeling through anti\u2010ROS and anti\u2010inflammatory pathways and may be used as a therapeutic option for PH treatment.<\/jats:p>","DOI":"10.1155\/2021\/6621232","type":"journal-article","created":{"date-parts":[[2021,1,28]],"date-time":"2021-01-28T16:05:15Z","timestamp":1611849915000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["[Retracted] S\u2010Nitroso\u2010L\u2010Cysteine Ameliorated Pulmonary Hypertension in the MCT\u2010Induced Rats through Anti\u2010ROS and Anti\u2010Inflammatory Pathways"],"prefix":"10.1155","volume":"2021","author":[{"given":"Moran","family":"Wang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pengcheng","family":"Luo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wei","family":"Shi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Junyi","family":"Guo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shengqi","family":"Huo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dan","family":"Yan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lulu","family":"Peng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cuntai","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiagao","family":"Lv","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Li","family":"Lin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2918-9164","authenticated-orcid":false,"given":"Sheng","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2021,1,28]]},"reference":[{"key":"e_1_2_9_1_2","doi-asserted-by":"publisher","DOI":"10.1161\/circresaha.115.304563"},{"key":"e_1_2_9_2_2","doi-asserted-by":"publisher","DOI":"10.1161\/atvbaha.117.309212"},{"key":"e_1_2_9_3_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajpcell.00382.2006"},{"key":"e_1_2_9_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.niox.2018.01.007"},{"key":"e_1_2_9_5_2","doi-asserted-by":"publisher","DOI":"10.1089\/dna.2009.0865"},{"key":"e_1_2_9_6_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0118655"},{"key":"e_1_2_9_7_2","doi-asserted-by":"publisher","DOI":"10.1161\/circulationaha.112.133413"},{"key":"e_1_2_9_8_2","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddn214"},{"key":"e_1_2_9_9_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1209038"},{"key":"e_1_2_9_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ceb.2010.11.003"},{"key":"e_1_2_9_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.biocel.2014.05.010"},{"key":"e_1_2_9_12_2","doi-asserted-by":"publisher","DOI":"10.1161\/jaha.116.004865"},{"key":"e_1_2_9_13_2","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200709-1369PP"},{"key":"e_1_2_9_14_2","doi-asserted-by":"publisher","DOI":"10.1161\/circresaha.113.301141"},{"key":"e_1_2_9_15_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.83.6.2038"},{"key":"e_1_2_9_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2007.10.055"},{"key":"e_1_2_9_17_2","doi-asserted-by":"publisher","DOI":"10.1254\/jphs.09279FP"},{"key":"e_1_2_9_18_2","doi-asserted-by":"publisher","DOI":"10.1165\/rcmb.2011-0439OC"},{"key":"e_1_2_9_19_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajplung.00184.2018"},{"key":"e_1_2_9_20_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.091109498"},{"key":"e_1_2_9_21_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.110.236927"},{"key":"e_1_2_9_22_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.108.182014"},{"key":"e_1_2_9_23_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.161272598"},{"key":"e_1_2_9_24_2","doi-asserted-by":"publisher","DOI":"10.1038\/s12276-018-0068-3"},{"key":"e_1_2_9_25_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12931-019-1090-2"},{"key":"e_1_2_9_26_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.redox.2015.09.021"},{"key":"e_1_2_9_27_2","doi-asserted-by":"publisher","DOI":"10.3892\/ijmm.2017.3334"},{"key":"e_1_2_9_28_2","doi-asserted-by":"publisher","DOI":"10.1089\/ars.2013.5223"},{"key":"e_1_2_9_29_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00869.2013"},{"key":"e_1_2_9_30_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.yjmcc.2004.09.007"},{"key":"e_1_2_9_31_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.redox.2015.07.016"},{"key":"e_1_2_9_32_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtcvs.2020.08.014"},{"key":"e_1_2_9_33_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2017.10.068"},{"key":"e_1_2_9_34_2","doi-asserted-by":"publisher","DOI":"10.1172\/jci74985"},{"key":"e_1_2_9_35_2","doi-asserted-by":"publisher","DOI":"10.1002\/jcp.28117"},{"key":"e_1_2_9_36_2","doi-asserted-by":"publisher","DOI":"10.1096\/fj.14-268276"},{"key":"e_1_2_9_37_2","doi-asserted-by":"publisher","DOI":"10.1002\/jcp.27527"},{"key":"e_1_2_9_38_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2020.117726"},{"key":"e_1_2_9_39_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00395-014-0416-y"}],"updated-by":[{"DOI":"10.1155\/2023\/9781259","type":"retraction","label":"Retraction","source":"retraction-watch","updated":{"date-parts":[[2023,10,11]],"date-time":"2023-10-11T00:00:00Z","timestamp":1696982400000},"record-id":"62079"},{"DOI":"10.1155\/2023\/9781259","type":"retraction","label":"Retraction","source":"publisher","updated":{"date-parts":[[2023,10,11]],"date-time":"2023-10-11T00:00:00Z","timestamp":1696982400000}}],"container-title":["Oxidative Medicine and Cellular Longevity"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/omcl\/2021\/6621232.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/omcl\/2021\/6621232.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1155\/2021\/6621232","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,8,7]],"date-time":"2024-08-07T14:30:43Z","timestamp":1723041043000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1155\/2021\/6621232"}},"subtitle":[],"editor":[{"given":"Hao","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2021,1]]},"references-count":39,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2021,1]]}},"alternative-id":["10.1155\/2021\/6621232"],"URL":"https:\/\/doi.org\/10.1155\/2021\/6621232","archive":["Portico"],"relation":{},"ISSN":["1942-0900","1942-0994"],"issn-type":[{"value":"1942-0900","type":"print"},{"value":"1942-0994","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,1]]},"assertion":[{"value":"2020-11-09","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-01-07","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-01-28","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"6621232"}}