{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,21]],"date-time":"2026-02-21T09:45:08Z","timestamp":1771667108466,"version":"3.50.1"},"reference-count":28,"publisher":"Wiley","license":[{"start":{"date-parts":[[2021,10,29]],"date-time":"2021-10-29T00:00:00Z","timestamp":1635465600000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Case Reports in Veterinary Medicine"],"published-print":{"date-parts":[[2021,10,29]]},"abstract":"<jats:p>A 9-year-old male intact mixed-breed dog was presented to The Ohio State University Veterinary Medical Center for evaluation of two days\u2019 duration of weakness, lethargy, inappetence, and one episode of vomiting the day of presentation. On presentation, the dog was depressed and tetraparetic. He was noted to be icteric and dehydrated. Obesity and truncal alopecia with a \u201crat tail\u201d appearance were observed. Diagnostic testing revealed evidence of an acute hepatopathy and peritonitis. Given the dog\u2019s neurologic status, physical examination abnormalities, including a \u201ctragic facial expression\u201d, and hyperlipidemia, there was concern for possible myxedema coma. A thyroid panel was consistent with hypothyroidism. The dog experienced respiratory arrest prior to initiation of therapy, and an autopsy confirmed the presence of subacute necrotizing cholangiohepatitis, marked atherosclerosis, and severe thyroid atrophy. These clinical and pathologic changes were supportive of myxedema coma.<\/jats:p>","DOI":"10.1155\/2021\/6622767","type":"journal-article","created":{"date-parts":[[2021,10,29]],"date-time":"2021-10-29T20:35:10Z","timestamp":1635539710000},"page":"1-8","source":"Crossref","is-referenced-by-count":2,"title":["Myxedema Coma and Acute Hepatopathy in a Dog with Severe Atherosclerosis"],"prefix":"10.1155","volume":"2021","author":[{"given":"Leah C.","family":"Giralico","sequence":"first","affiliation":[{"name":"Department of Veterinary Clinical Sciences, The Ohio State University College of Veterinary Medicine, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3143-0161","authenticated-orcid":true,"given":"Rebecca","family":"Makii","sequence":"additional","affiliation":[{"name":"Department of Veterinary Clinical Sciences, The Ohio State University College of Veterinary Medicine, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Betsy A.","family":"Pray","sequence":"additional","affiliation":[{"name":"Department of Veterinary Biosciences, The Ohio State University College of Veterinary Medicine, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6505-8068","authenticated-orcid":true,"given":"Valerie J.","family":"Parker","sequence":"additional","affiliation":[{"name":"Department of Veterinary Clinical Sciences, The Ohio State University College of Veterinary Medicine, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.1111\/vec.12304"},{"issue":"5","key":"2","doi-asserted-by":"crossref","first-page":"761","DOI":"10.2460\/javma.1994.204.05.761","article-title":"Hypothyroidism in dogs: 66 cases (1987-1992)","volume":"204","author":"D. 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