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The extract of U. hecatantha showed activity against both parasites with IC50 values of 7\u2009\u00b5g\/mL and 31\u2009\u00b5g\/mL, respectively. Fractionation of the dichloromethane extract led to the isolation of euparin, jaceidin, santhemoidin C, and eucannabinolide. The sesquiterpene lactones eucannabinolide and santhemoidin C were active on T. cruzi with IC50 values of 10\u2009\u00b1\u20092\u2009\u00b5M (4.2\u2009\u00b5g\/mL) and 18\u2009\u00b1\u20093\u2009\u00b5M (7.6\u2009\u00b5g\/mL), respectively. Euparin and santhemoidin C were the most active on L. infantum with IC50 values of 18\u2009\u00b1\u20094\u2009\u00b5M (3.9\u2009\u00b5g\/mL) and 19\u2009\u00b1\u20094\u2009\u00b5M (8.0\u2009\u00b5g\/mL), respectively. Eucannabinolide has also shown drug-like pharmacokinetic and toxicity properties.<\/jats:p>","DOI":"10.1155\/2021\/6622894","type":"journal-article","created":{"date-parts":[[2021,2,13]],"date-time":"2021-02-13T23:39:52Z","timestamp":1613259592000},"page":"1-7","source":"Crossref","is-referenced-by-count":10,"title":["Antiprotozoal Compounds from Urolepis hecatantha (Asteraceae)"],"prefix":"10.1155","volume":"2021","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1970-9904","authenticated-orcid":true,"given":"Orlando G.","family":"Elso","sequence":"first","affiliation":[{"name":"Universidad de Buenos Aires, Facultad de Farmacia y Bioqu\u00edmica, C\u00e1tedra de Farmacognosia, Jun\u00edn 956, Buenos Aires 1113, Argentina"},{"name":"CONICET\u2013Universidad de Buenos Aires, Instituto de Qu\u00edmica y Metabolismo del F\u00e1rmaco (IQUIMEFA), Jun\u00edn 956, Buenos Aires 1113, Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6457-3591","authenticated-orcid":true,"given":"Maria","family":"Clavin","sequence":"additional","affiliation":[{"name":"Universidad de Buenos Aires, Facultad de Farmacia y Bioqu\u00edmica, C\u00e1tedra de Farmacognosia, Jun\u00edn 956, Buenos Aires 1113, Argentina"},{"name":"CONICET\u2013Universidad de Buenos Aires, Instituto de Qu\u00edmica y Metabolismo del F\u00e1rmaco (IQUIMEFA), Jun\u00edn 956, Buenos Aires 1113, Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2594-334X","authenticated-orcid":true,"given":"Natalia","family":"Hernandez","sequence":"additional","affiliation":[{"name":"Universidad de Buenos Aires, Facultad de Farmacia y Bioqu\u00edmica, C\u00e1tedra de Farmacognosia, Jun\u00edn 956, Buenos Aires 1113, Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3805-1236","authenticated-orcid":true,"given":"Tom\u00e1s","family":"Sgarlata","sequence":"additional","affiliation":[{"name":"Universidad de Buenos Aires, Facultad de Farmacia y Bioqu\u00edmica, C\u00e1tedra de Farmacognosia, Jun\u00edn 956, Buenos Aires 1113, Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7215-7099","authenticated-orcid":true,"given":"Hern\u00e1n","family":"Bach","sequence":"additional","affiliation":[{"name":"Universidad de Buenos Aires, Facultad de Farmacia y Bioqu\u00edmica, Museo de Farmacobot\u00e1nica, Jun\u00edn 956, Buenos Aires 1113, Argentina"},{"name":"Instituto de Recursos Biol\u00f3gicos INTA-Hurlingham, De los Reseros y N. 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