{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,13]],"date-time":"2026-01-13T13:51:56Z","timestamp":1768312316774,"version":"3.49.0"},"reference-count":42,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2021,6,11]],"date-time":"2021-06-11T00:00:00Z","timestamp":1623369600000},"content-version":"vor","delay-in-days":161,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["BioMed Research International"],"published-print":{"date-parts":[[2021,1]]},"abstract":"<jats:p><jats:italic>Background<\/jats:italic>. DNA methylation is an important part of epigenetic modification, and its abnormality is closely related to esophageal adenocarcinoma (EAC). This study was aimed at using bioinformatics analysis to identify methylation\u2010driven genes (MDGs) in EAC patients and establish a risk model as a biological indicator of EAC prognosis. <jats:italic>Method<\/jats:italic>. Downloaded EAC DNA methylation, transcriptome, and related clinical data from TCGA database. MethylMix was used to identify MDGs. R package clusterProfiler and the ConsensusPathDB online database were used to analyze the rich functions and pathways of these MDGs. The prognostic risk model was established by univariate Cox regression, Lasso regression, and multivariate Cox regression analysis. Finally each MDG in the model were carried out through the survival R package. <jats:italic>Results<\/jats:italic>. A total of 273 MDGs were identified, which were enriched in transcriptional regulation and embryonic organ morphogenesis. Cox regression analysis established a risk model consisting of GPBAR1, OLFM4, FOXI2, and CASP10. In addition, further survival analysis revealed that OLFM4 and its two related sites were significantly related to the EAC patients\u2019 survival. <jats:italic>Conclusion<\/jats:italic>. In summary, this study used bioinformatics methods to identify EAC MDGs and established a reliable risk prognosis model. It provided potential biomarkers for the early treatment and prognosis evaluation of EAC.<\/jats:p>","DOI":"10.1155\/2021\/6628391","type":"journal-article","created":{"date-parts":[[2021,6,11]],"date-time":"2021-06-11T17:37:22Z","timestamp":1623433042000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Identification of Prognostic Risk Model Based on DNA Methylation\u2010Driven Genes in Esophageal Adenocarcinoma"],"prefix":"10.1155","volume":"2021","author":[{"given":"Yuhua","family":"Chen","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jinjie","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hao","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhanghao","family":"Huang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1653-6243","authenticated-orcid":false,"given":"Li","family":"Qian","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6296-1585","authenticated-orcid":false,"given":"Wei","family":"Shi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2021,6,11]]},"reference":[{"key":"e_1_2_8_1_2","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21492"},{"key":"e_1_2_8_2_2","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2015.08.054"},{"key":"e_1_2_8_3_2","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2017.08.023"},{"key":"e_1_2_8_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.gie.2018.04.2352"},{"key":"e_1_2_8_5_2","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21590"},{"key":"e_1_2_8_6_2","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2013-305372"},{"key":"e_1_2_8_7_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10388-014-0465-1"},{"key":"e_1_2_8_8_2","doi-asserted-by":"publisher","DOI":"10.1038\/nm.2305"},{"key":"e_1_2_8_9_2","doi-asserted-by":"publisher","DOI":"10.1101\/gad.947102"},{"key":"e_1_2_8_10_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12943-021-01330-w"},{"key":"e_1_2_8_11_2","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkaa1104"},{"key":"e_1_2_8_12_2","doi-asserted-by":"publisher","DOI":"10.1007\/s12013-013-9555-2"},{"key":"e_1_2_8_13_2","doi-asserted-by":"publisher","DOI":"10.3390\/cancers12113088"},{"key":"e_1_2_8_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cels.2019.06.006"},{"key":"e_1_2_8_15_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13059-014-0579-8"},{"key":"e_1_2_8_16_2","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btv020"},{"key":"e_1_2_8_17_2","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkv007"},{"key":"e_1_2_8_18_2","doi-asserted-by":"publisher","DOI":"10.1089\/omi.2011.0118"},{"key":"e_1_2_8_19_2","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btv300"},{"key":"e_1_2_8_20_2","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkq1156"},{"key":"e_1_2_8_21_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa032520"},{"key":"e_1_2_8_22_2","doi-asserted-by":"publisher","DOI":"10.1097\/SLA.0b013e3181e9da0e"},{"key":"e_1_2_8_23_2","doi-asserted-by":"publisher","DOI":"10.1097\/EDE.0000000000000004"},{"key":"e_1_2_8_24_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41525-017-0016-5"},{"key":"e_1_2_8_25_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13045-020-00981-4"},{"key":"e_1_2_8_26_2","first-page":"85","article-title":"Obesity, alcohol, and tobacco as risk factors for cancers of the esophagus and gastric cardia: adenocarcinoma versus squamous cell carcinoma","volume":"4","author":"Vaughan T. 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