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Alveolar echinococcosis (AE) is a zoonosis caused by the larval stage of the metacestode <jats:italic>Echinococcosis multilocularis<\/jats:italic> with a tumor\u2010like behavior in the targeted organ, especially in the liver. Surgery with albendazole is first\u2010line modality for AE. Drug discontinuation is usually based upon the parasitic viability shown by the positron emission tomography (PET) scan. However, as a demanding and expensive method, it is not widely practiced in majority of the endemic regions. Further understanding on the cytokine and chemokine response profiles in AE patients may provide an interesting insight for potential markers in viability assessment. <jats:italic>Methods<\/jats:italic>. Mice were inoculated with <jats:italic>Echinococcus multilocularis<\/jats:italic> intrahepatically to develop the hepatic AE murine model. Oral albendazole administration was then applied for three months after the first inoculation, and peripheral and regional immune cells including type 1 T helper cells (Th), Th2, Th17, regulatory T (Treg) cells, related cytokines, and chemokines were examined. <jats:italic>Results<\/jats:italic>. The hepatic AE lesion was confirmed by ultrasound examination resulting in a successful rate of 70%. Among the 17 cytokines and chemokines detected, plasma levels of IL\u201023 were significantly higher in <jats:italic>E. multilocularis<\/jats:italic>\u2010infected mice when compared to the control group; furthermore, more obvious increasing levels were found after albendazole treatment (<jats:italic>p<\/jats:italic> &lt; 0.05). All chemokine levels other than eotaxin and MCP\u20103 were slightly higher in <jats:italic>E. multilocularis<\/jats:italic>\u2010infected mice compared to the control group (<jats:italic>p<\/jats:italic> &gt; 0.05). Eotaxin levels were significantly decreased in mice with <jats:italic>E. multilocularis<\/jats:italic> infection followed by albendazole treatment (<jats:italic>p<\/jats:italic> &lt; 0.05). Both IL\u201017A and IL\u201023 expressions in hepatic AE lesions were significantly higher and related with disease activity. <jats:italic>Conclusion<\/jats:italic>. Albendazole administration influenced the balance of immune response and promotes the secretion of proinflammatory factors which is beneficial to parasite clearance. IL\u201023 seems to be associated with the successful albendazole treatment in mice with <jats:italic>E. multilocularis<\/jats:italic> infection; such a change could be translated into clinical application in the near future.<\/jats:p>","DOI":"10.1155\/2021\/6628814","type":"journal-article","created":{"date-parts":[[2021,5,7]],"date-time":"2021-05-07T22:20:28Z","timestamp":1620426028000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Impact of Albendazole on Cytokine and Chemokine Response Profiles in <i>Echinococcus multilocularis<\/i>\u2010Inoculated 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