{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,23]],"date-time":"2026-08-23T14:27:54Z","timestamp":1787495274949,"version":"build-2736575974"},"reference-count":19,"publisher":"Wiley","license":[{"start":{"date-parts":[[2021,8,12]],"date-time":"2021-08-12T00:00:00Z","timestamp":1628726400000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100012021","name":"Iran University of Medical Sciences","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100012021","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Evidence-Based Complementary and Alternative Medicine"],"published-print":{"date-parts":[[2021,8,12]]},"abstract":"<jats:p>\n                    Objective. This study aimed to appraise the potential effects of Rosa damascena preparation on nonalcoholic fatty liver disease (NAFLD). Design. In the randomized, double-blind placebo-controlled clinical trials, seventy-four patients with NAFLD were prescribed either 1\u2009g Rosa damascena powder or placebo three times in a day for 12 weeks. All patients were provided the lifestyle modification instructions and recommended following them precisely. ALT, AST, FBS, and lipid profiles were measured at the baseline after 12 weeks of studying. The Mann\u2013Whitney U test was correctly used to compare the changes of variables among the groups. Results. Seventy-two patients completed the study in two groups. Sixty-seven patients were men, and the mean\u2009\u00b1\u2009standard deviation of age was 40.11\u2009\u00b1\u20099.05 years. The Rosa damascena group showed a considerable decrease in the serum ALT (23.83\u2009\u00b1\u200924.82 vs. 16.19\u2009\u00b1\u200927.41,\n                    <jats:inline-formula>\n                      <a:math xmlns:a=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M1\">\n                        <a:mi>p<\/a:mi>\n                        <a:mo>=<\/a:mo>\n                        <a:mn>0.042<\/a:mn>\n                      <\/a:math>\n                    <\/jats:inline-formula>\n                    ), waist circumference (99.73\u2009\u00b1\u200910.01 vs. 101.52\u2009\u00b1\u20098.84,\n                    <jats:inline-formula>\n                      <c:math xmlns:c=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M2\">\n                        <c:mi>p<\/c:mi>\n                        <c:mo>=<\/c:mo>\n                        <c:mn>0.003<\/c:mn>\n                      <\/c:math>\n                    <\/jats:inline-formula>\n                    ), triglyceride (TG) (186.29\u2009\u00b1\u200976.75 vs. 184.47\u2009\u00b1\u200973.05,\n                    <jats:inline-formula>\n                      <e:math xmlns:e=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M3\">\n                        <e:mi>p<\/e:mi>\n                        <e:mo>=<\/e:mo>\n                        <e:mn>0.001<\/e:mn>\n                      <\/e:math>\n                    <\/jats:inline-formula>\n                    ), cholesterol (167.47\u2009\u00b1\u200934.48 vs. 184.11\u2009\u00b1\u200933.54,\n                    <jats:inline-formula>\n                      <g:math xmlns:g=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M4\">\n                        <g:mi>p<\/g:mi>\n                        <g:mo>=<\/g:mo>\n                        <g:mn>0.001<\/g:mn>\n                      <\/g:math>\n                    <\/jats:inline-formula>\n                    ), low-density lipoprotein (LDL) (99.17\u2009\u00b1\u200928.66 vs. 107.52\u2009\u00b1\u200925.42,\n                    <jats:inline-formula>\n                      <i:math xmlns:i=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M5\">\n                        <i:mi>p<\/i:mi>\n                        <i:mo>=<\/i:mo>\n                        <i:mn>0.001<\/i:mn>\n                      <\/i:math>\n                    <\/jats:inline-formula>\n                    ), and elevation in serum high-density lipoprotein (HDL) (41.85\u2009\u00b1\u20096.56 vs. 39.20\u2009\u00b1\u20095.00,\n                    <jats:inline-formula>\n                      <k:math xmlns:k=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M6\">\n                        <k:mi>p<\/k:mi>\n                        <k:mo>&lt;<\/k:mo>\n                        <k:mn>0.007<\/k:mn>\n                      <\/k:math>\n                    <\/jats:inline-formula>\n                    ) compared to the control group. Improving fatty liver degree due to liver ultrasound was higher in the Rosa damascena group than the control group (\n                    <jats:inline-formula>\n                      <m:math xmlns:m=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M7\">\n                        <m:mi>p<\/m:mi>\n                        <m:mo>=<\/m:mo>\n                        <m:mn>0.001<\/m:mn>\n                      <\/m:math>\n                    <\/jats:inline-formula>\n                    ). Conclusion. Rosa damascena meaningfully improves liver function in NAFLD. Hence, it can be recommended along with lifestyle modification for these patients. Further studies are recommended with a larger sample size.\n                  <\/jats:p>","DOI":"10.1155\/2021\/6628911","type":"journal-article","created":{"date-parts":[[2021,8,13]],"date-time":"2021-08-13T15:35:09Z","timestamp":1628868909000},"page":"1-6","source":"Crossref","is-referenced-by-count":9,"title":["The Efficacy of Rosa damascena on Liver Enzymes in Nonalcoholic Fatty Liver Disease: A Randomized Double-Blind Clinical Trial"],"prefix":"10.1155","volume":"2021","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1165-0848","authenticated-orcid":true,"given":"S. Ali Al-Hadi","family":"Moravej","sequence":"first","affiliation":[{"name":"Research Institute for Islamic and Complementary Medicine, Iran University of Medical Sciences, Tehran, Iran"},{"name":"Department of Persian Medicine, School of Persian Medicine, Iran University of Medical Sciences, Tehran, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9093-5525","authenticated-orcid":true,"given":"Asie","family":"Shojaii","sequence":"additional","affiliation":[{"name":"Research Institute for Islamic and Complementary Medicine, Iran University of Medical Sciences, Tehran, Iran"},{"name":"Department of Traditional Pharmacy, School of Persian Medicine, Tehran, University of Medical Sciences, Tehran, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0005-5792","authenticated-orcid":true,"given":"Fataneh","family":"Hashem Dabaghian","sequence":"additional","affiliation":[{"name":"Research Institute for Islamic and Complementary Medicine, Iran University of Medical Sciences, Tehran, Iran"},{"name":"Department of Persian Medicine, School of Persian Medicine, Iran University of Medical Sciences, Tehran, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8912-0225","authenticated-orcid":true,"given":"S. Ferdows","family":"Jazayeri","sequence":"additional","affiliation":[{"name":"Research Institute for Islamic and Complementary Medicine, Iran University of Medical Sciences, Tehran, Iran"},{"name":"Department of Persian Medicine, School of Persian Medicine, Iran University of Medical Sciences, Tehran, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7845-2811","authenticated-orcid":true,"given":"S. Zahra","family":"Moravej","sequence":"additional","affiliation":[{"name":"Ahvaz Jundishapur University of Medical Sciences, Department of Pharmacy, Ahvaz, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4926-9436","authenticated-orcid":true,"given":"Ebrahim","family":"Khadem","sequence":"additional","affiliation":[{"name":"Department of Traditional Medicine, School of Traditional Medicine, Tehran University of Medical Sciences, Tehran, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5269-4644","authenticated-orcid":true,"given":"Shahram","family":"Agah","sequence":"additional","affiliation":[{"name":"Gastrointestinal and Liver Diseases Research Center, Iran University of Medical Sciences, Tehran, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6123-778X","authenticated-orcid":true,"given":"Roshanak","family":"Ghods","sequence":"additional","affiliation":[{"name":"Research Institute for Islamic and Complementary Medicine, Iran University of Medical Sciences, Tehran, Iran"},{"name":"Department of Persian Medicine, School of Persian Medicine, Iran University of Medical Sciences, Tehran, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","reference":[{"issue":"4","key":"1","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1016\/j.dsx.2018.03.016","article-title":"Non-alcoholic fatty liver disease and associated dietary and lifestyle risk factors","volume":"12","author":"Y. 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AzamKhan","year":"2013"},{"key":"17","doi-asserted-by":"publisher","DOI":"10.1007\/s11306-013-0604-z"},{"key":"18","doi-asserted-by":"publisher","DOI":"10.1002\/mnfr.201900261"},{"key":"19","doi-asserted-by":"publisher","DOI":"10.1080\/03009740510018624"}],"container-title":["Evidence-Based Complementary and Alternative Medicine"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/ecam\/2021\/6628911.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/ecam\/2021\/6628911.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/ecam\/2021\/6628911.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,8,13]],"date-time":"2021-08-13T15:35:13Z","timestamp":1628868913000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.hindawi.com\/journals\/ecam\/2021\/6628911\/"}},"subtitle":[],"editor":[{"given":"Reza B.","family":"Jalili","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2021,8,12]]},"references-count":19,"alternative-id":["6628911","6628911"],"URL":"https:\/\/doi.org\/10.1155\/2021\/6628911","relation":{},"ISSN":["1741-4288","1741-427X"],"issn-type":[{"value":"1741-4288","type":"electronic"},{"value":"1741-427X","type":"print"}],"subject":[],"published":{"date-parts":[[2021,8,12]]}}}