{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T01:49:16Z","timestamp":1787017756673,"version":"build-2736575974"},"reference-count":28,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2021,4,2]],"date-time":"2021-04-02T00:00:00Z","timestamp":1617321600000},"content-version":"vor","delay-in-days":91,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["BioMed Research International"],"published-print":{"date-parts":[[2021,1]]},"abstract":"<jats:p>\n                    Oral submucous fibrosis (OSMF) is considered a premalignant condition characterized by aggressive fibrosis of the submucosal tissues of the oral cavity reflecting its malignant transformation potential. Activation of transforming growth factor beta (TGF\u2010\n                    <jats:italic>\u03b2<\/jats:italic>\n                    ) signaling has been reported to lead increased collagen production and fibrosis. Recently, significant upregulation of TGF\u2010\n                    <jats:italic>\u03b2<\/jats:italic>\n                    1 has been reported in OSMF as compared to normal tissues. Therefore, inhibition of the TGF\u2010\n                    <jats:italic>\u03b2<\/jats:italic>\n                    1 may pave for the development of therapeutics of OSMF. Based on the structure\u2010assisted drug designing, we found \u201csilmitasertib\u201d as potent inhibitor of TGF\u2010\n                    <jats:italic>\u03b2<\/jats:italic>\n                    1. We suggest that this molecule can be validated and implemented for the treatment of OSMF.\n                  <\/jats:p>","DOI":"10.1155\/2021\/6631848","type":"journal-article","created":{"date-parts":[[2021,4,2]],"date-time":"2021-04-02T15:05:07Z","timestamp":1617375907000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Small Molecule \u201cSilmitasertib\u201d Repurposed as Inhibitor of Transforming Growth Factor Beta 1 for the Development of Therapeutics for Oral Submucous Fibrosis"],"prefix":"10.1155","volume":"2021","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9017-9224","authenticated-orcid":false,"given":"Nezar","family":"Boreak","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,4,2]]},"reference":[{"key":"e_1_2_9_1_2","doi-asserted-by":"publisher","DOI":"10.1016\/s1079-2104(96)80404-5"},{"key":"e_1_2_9_2_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF02872409"},{"key":"e_1_2_9_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jobcr.2020.03.015"},{"key":"e_1_2_9_4_2","doi-asserted-by":"publisher","DOI":"10.7314\/apjcp.2013.14.5.3323"},{"key":"e_1_2_9_5_2","doi-asserted-by":"publisher","DOI":"10.4103\/0019-509X.146724"},{"key":"e_1_2_9_6_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0714.2006.00485.x"},{"key":"e_1_2_9_7_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10006-010-0219-8"},{"key":"e_1_2_9_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.oraloncology.2012.12.004"},{"key":"e_1_2_9_9_2","doi-asserted-by":"publisher","DOI":"10.4103\/njms.NJMS_32_17"},{"key":"e_1_2_9_10_2","doi-asserted-by":"publisher","DOI":"10.1006\/cyto.1997.0342"},{"key":"e_1_2_9_11_2","doi-asserted-by":"publisher","DOI":"10.3109\/08977194.2011.582839"},{"key":"e_1_2_9_12_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0051806"},{"key":"e_1_2_9_13_2","doi-asserted-by":"publisher","DOI":"10.1002\/path.2786"},{"key":"e_1_2_9_14_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0129252"},{"key":"e_1_2_9_15_2","doi-asserted-by":"publisher","DOI":"10.1080\/09291016.2018.1498197"},{"key":"e_1_2_9_16_2","doi-asserted-by":"publisher","DOI":"10.1002\/elps.200900140"},{"key":"e_1_2_9_17_2","doi-asserted-by":"publisher","DOI":"10.1021\/ja1005306"},{"key":"e_1_2_9_18_2","doi-asserted-by":"publisher","DOI":"10.1002\/jcc.21334"},{"key":"e_1_2_9_19_2","doi-asserted-by":"publisher","DOI":"10.1002\/elps.1150181505"},{"key":"e_1_2_9_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.str.2009.02.010"},{"key":"e_1_2_9_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bpj.2009.11.011"},{"key":"e_1_2_9_22_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00894-015-2772-4"},{"key":"e_1_2_9_23_2","doi-asserted-by":"publisher","DOI":"10.3390\/ijms20122940"},{"key":"e_1_2_9_24_2","doi-asserted-by":"publisher","DOI":"10.1038\/aps.2012.109"},{"key":"e_1_2_9_25_2","doi-asserted-by":"publisher","DOI":"10.38150\/sajeb.6(4).p124-130"},{"key":"e_1_2_9_26_2","doi-asserted-by":"publisher","DOI":"10.1080\/07420528.2021.1903027"},{"key":"e_1_2_9_27_2","first-page":"433","article-title":"The role of hydrogen-bonds in drug binding","volume":"289","author":"Wade R. 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