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The incidence of infertility for females has significantly increased due to various factors such as social pressure, late marriage, and late childbirth, and its harm includes heavy economic burden, psychological shadow, and even marriage failure. Conventional solutions, such as hormone therapy, in vitro fertilization (IVF), and embryo transfer, have the limitations of unsatisfied obstetric outcomes and serious adverse events. Currently, complementary and alternative medicine (CAM), as a new treatment for infertility, is gradually challenging the dominant position of traditional therapies in the treatment of infertility. CAM claims that it can adjust and harmonize the state of the female body from a holistic approach to achieve a better therapeutic effect and has been increasingly used by infertile women. Meanwhile, some controversial issues also appeared; that is, some randomized controlled trials (RCTs) confirmed that CAM had no obvious effect on infertility, and the mechanism of its effect could not reach a consensus. To clarify CAM effectiveness, safety, and mechanism, this paper systematically reviewed the literature about its treatment of female infertility collected from PubMed and CNKI databases and mainly introduced acupuncture, moxibustion, and oral Chinese herbal medicine. In addition, we also briefly summarized psychological intervention, biosimilar electrical stimulation, homeopathy, hyperbaric oxygen therapy, etc.<\/jats:p>","DOI":"10.1155\/2021\/6634309","type":"journal-article","created":{"date-parts":[[2021,4,26]],"date-time":"2021-04-26T21:15:52Z","timestamp":1619471752000},"page":"1-21","source":"Crossref","is-referenced-by-count":32,"title":["The Efficacy of Complementary and Alternative Medicine in the Treatment of Female Infertility"],"prefix":"10.1155","volume":"2021","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4493-3534","authenticated-orcid":true,"given":"Jiaxing","family":"Feng","sequence":"first","affiliation":[{"name":"Heilongjiang University of Chinese Medicine, Harbin, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4228-7225","authenticated-orcid":true,"given":"Jing","family":"Wang","sequence":"additional","affiliation":[{"name":"People\u2019s Hospital of Langfang City, Langfang, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8517-7603","authenticated-orcid":true,"given":"Yuehui","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, First Affiliated Hospital, Heilongjiang University of Chinese Medicine, Harbin, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yizhuo","family":"Zhang","sequence":"additional","affiliation":[{"name":"Heilongjiang University of Chinese Medicine, Harbin, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liyan","family":"Jia","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, First Affiliated Hospital, Heilongjiang University of Chinese Medicine, Harbin, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dongqi","family":"Zhang","sequence":"additional","affiliation":[{"name":"Heilongjiang University of Chinese Medicine, Harbin, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiao","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Acupuncture and Moxibustion, Second Affiliated Hospital, Heilongjiang University of Chinese Medicine, Harbin, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanhua","family":"Han","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, First Affiliated Hospital, Heilongjiang University of Chinese Medicine, Harbin, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0484-7255","authenticated-orcid":true,"given":"Shoujuan","family":"Luo","sequence":"additional","affiliation":[{"name":"Digestive Hospital of Heilongjiang Hospital, Harbin, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.1186\/s12958-015-0032-1"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.1093\/humupd\/dmv016"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.1016\/j.juro.2018.06.059"},{"key":"4","volume-title":"Fertility: Assessment and Treatment for People with Fertility Problems","year":"2013"},{"key":"5","doi-asserted-by":"publisher","DOI":"10.1016\/s0889-8529(05)70044-x"},{"key":"6","doi-asserted-by":"publisher","DOI":"10.1159\/000435773"},{"issue":"4","key":"7","article-title":"Assisted reproduction and risk of depressive relapse: considerations for treatment","volume":"25","author":"M. 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